Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Naoaki Shinzawa"'
Autor:
Shiroh Iwanaga, Rie Kubota, Tsubasa Nishi, Sumalee Kamchonwongpaisan, Somdet Srichairatanakool, Naoaki Shinzawa, Din Syafruddin, Masao Yuda, Chairat Uthaipibull
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Plasmodium falciparum malaria is treated using artemisinin combination therapy (ACT), in which artemisinin is supplied along with partner drugs such as mefloquine, piperaquine, and lumefantrine. However, resistance has been reported in endemic region
Externí odkaz:
https://doaj.org/article/994ca7c9bea84ed992fa78d880984241
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The CRISPR/Cas9 system is a powerful genetic engineering technology for Plasmodium falciparum. We here report further improvement of the CRISPR/Cas9 system by combining the Cas9-expressing parasite with a liner donor template DNA. The Cas9-e
Externí odkaz:
https://doaj.org/article/b96891bd3e9d4dfa8a10bff40afe263f
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The emergence and spread of drug-resistant Plasmodium falciparum have compromised antimalarial efficacy and threatened the global malaria elimination campaign using artemisinin combination therapies. The impacts of amino acid substitutions in antimal
Externí odkaz:
https://doaj.org/article/a682a8177a0042cbbeb118966e964176
Autor:
Kentaro Tsukamoto, Naoaki Shinzawa, Akito Kawai, Masahiro Suzuki, Hiroyasu Kidoya, Nobuyuki Takakura, Hisateru Yamaguchi, Toshiki Kameyama, Hidehito Inagaki, Hiroki Kurahashi, Yasuhiko Horiguchi, Yohei Doi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pathogenic bacteria of the genus Bartonella can induce vasoproliferative lesions during infection. Here, Tsukamoto et al. show that this effect is caused by a secreted protein that induces cell proliferation and angiogenesis by acting as an analog of
Externí odkaz:
https://doaj.org/article/7c6bada9dc8c434fa191c36a4398ea29
Autor:
Daniel Addo-Gyan, Haruka Matsushita, Enya Sora, Tsubasa Nishi, Masao Yuda, Naoaki Shinzawa, Shiroh Iwanaga
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Spatial arrangement of chromosomes is responsible for gene expression in Plasmodium parasites. However, methods for rearranging chromosomes have not been established, which makes it difficult to investigate its role in detail. Here, we report a metho
Externí odkaz:
https://doaj.org/article/6d16249d95b944a4993a3757844d5718
Autor:
Masayuki Morita, Bernard N. Kanoi, Naoaki Shinzawa, Rie Kubota, Hiroyuki Takeda, Tatsuya Sawasaki, Takafumi Tsuboi, Eizo Takashima
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Precise subcellular localization of proteins is the key to elucidating the physiological role of these molecules in malaria parasite development, understanding of pathogenesis, and protective immunity. In Plasmodium falciparum, however, detection of
Externí odkaz:
https://doaj.org/article/d5c708d845fd44488bbe96ad290da318
Autor:
Izumi Taku, Tomohiro Hirai, Takashi Makiuchi, Naoaki Shinzawa, Shiroh Iwanaga, Takeshi Annoura, Kisaburo Nagamune, Tomoyoshi Nozaki, Yumiko Saito-Nakano
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)
Plasmodium falciparum extensively remodels human erythrocytes by exporting hundreds of parasite proteins. This remodeling is closely linked to the Plasmodium virulence-related functions and immune evasion. The N-terminal export signal named PEXEL (Pl
Externí odkaz:
https://doaj.org/article/1c417b4a961643819c12368416d5d7c7
Autor:
Shihono Teruya, Yukihiro Hiramatsu, Keiji Nakamura, Aya Fukui-Miyazaki, Kentaro Tsukamoto, Noriko Shinoda, Daisuke Motooka, Shota Nakamura, Keisuke Ishigaki, Naoaki Shinzawa, Takashi Nishida, Fuminori Sugihara, Yusuke Maeda, Yasuhiko Horiguchi
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordetella pertussis, but its role in pertussis, B. pertussis infection, remains unknown. In this study, we identified the T-type voltage-gated Ca2+ channel CaV3.1 as
Externí odkaz:
https://doaj.org/article/9697f89d3b9948dc8e71e8e9ee0e55ae
Autor:
Aya Fukui-Miyazaki, Hirono Toshima, Yukihiro Hiramatsu, Keisuke Okada, Keiji Nakamura, Keisuke Ishigaki, Naoaki Shinzawa, Hiroyuki Abe, Yasuhiko Horiguchi
Publikováno v:
mBio, Vol 9, Iss 4 (2018)
ABSTRACT Bordetella pertussis, Bordetella bronchiseptica, and Bordetella parapertussis share highly homologous virulence factors and commonly cause respiratory infections in mammals; however, their host specificities and disease severities differ, an
Externí odkaz:
https://doaj.org/article/29d632d63877402798169dcd2926c4f6
Autor:
Keisuke Ishigaki, Naoaki Shinzawa, Sayaka Nishikawa, Koichiro Suzuki, Aya Fukui-Miyazaki, Yasuhiko Horiguchi
Publikováno v:
mSphere, Vol 3, Iss 1 (2018)
ABSTRACT We describe a novel genome integration system that enables the introduction of DNA fragments as large as 50 kbp into the chromosomes of recipient bacteria. This system, named BPI, comprises a bacterial artificial chromosome vector and phage-
Externí odkaz:
https://doaj.org/article/ccb87c7d76c8458daaff9033d6fb1c04