Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nao Miyoshi"'
Autor:
Hajime Kashima, Fumiyasu Momose, Hiroshi Umehara, Nao Miyoshi, Naohisa Ogo, Daisuke Muraoka, Hiroshi Shiku, Naozumi Harada, Akira Asai
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156643 (2016)
Forkhead box protein p3 (Foxp3) is crucial to the development and suppressor function of regulatory T cells (Tregs) that have a significant role in tumor-associated immune suppression. Development of small molecule inhibitors of Foxp3 function is the
Externí odkaz:
https://doaj.org/article/af4abd82df1e4e5bbae3febfaf2d1e8b
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71646 (2013)
Some of the signal transducer and activator of transcription (STAT) family members are constitutively activated in a wide variety of human tumors. The activity of STAT depends on their Src homology 2 (SH2) domain-mediated binding to sequences contain
Externí odkaz:
https://doaj.org/article/c1f48f64e75d41d08b09815168d0a8ed
Autor:
Hiroyuki Takahashi, Nao Miyoshi, Hisashi Murakami, Yuta Okamura, Naohisa Ogo, Akimitsu Takagi, Daisuke Muraoka, Akira Asai
Publikováno v:
Cancer Immunology, Immunotherapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::024f721d9ee9b297cffcc125fe8309ae
https://doi.org/10.1007/s00262-023-03440-4
https://doi.org/10.1007/s00262-023-03440-4
Autor:
Ryota, Fukai, Naohisa, Ogo, Taiki, Ichida, Masayoshi, Yamane, Jun-Ichi, Sawada, Nao, Miyoshi, Hisashi, Murakami, Akira, Asai
Publikováno v:
European journal of medicinal chemistry. 215
Kinesin spindle protein (KSP) is expressed only in cells undergoing cell division, and hence represents an attractive target for the treatment of cancer. Several KSP inhibitors have been developed and undergone clinical trial, but their clinical use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7c9d498d72fcd50976193fb0a487016
https://pubmed.ncbi.nlm.nih.gov/33640763
https://pubmed.ncbi.nlm.nih.gov/33640763
Autor:
Ryuta Yamazaki, Yumiko Suzuki, Ayana Otake, Akira Asai, Hirosuke Ishii, Masashi Tachikawa, Nao Miyoshi, Kenta Kuroiwa, Yuki Fujimaki, Kotaro Nishiyama, Satoshi Ueno, Kei Manabe, Kensuke Hayashi
Publikováno v:
ACS Med Chem Lett
[Image: see text] As a part of our continuous structure–activity relationship (SAR) studies on 1-(quinazolin-4-yl)-1-(4-methoxyphenyl)ethan-1-ols, the synthesis of derivatives and their cytotoxicity against the human lung cancer cell line A549 were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0aa0cee56ed6219f922687f241eab8
https://europepmc.org/articles/PMC7294709/
https://europepmc.org/articles/PMC7294709/
Autor:
F. Porta, Nao Miyoshi, Byoung Mog Kwon, Arianna Gelain, Daniela Barlocco, Giorgio Facchetti, Isabella Rimoldi, Yena Jin, Akira Asai, Silvia Marchianò, D. Masciocchi, Valentina Gandin, Fiorella Meneghetti, Cristina Marzano, Stefania Villa, Nicola Ferri
Publikováno v:
European Journal of Medicinal Chemistry. 131:196-206
New Pt(II) complexes (Pt-1-3) bearing 1,2,5-oxadiazole ligands (1-3) were synthesized, characterized and evaluated for their ability to disrupt STAT3 dimerization. Ligand 3·HCl showed cytotoxic effects on HCT-116 cells (IC50 = 95.2 μM) and a select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a337a8a4b4447e80c4dd57ae1f21e7db
https://doi.org/10.1016/j.ejmech.2017.03.017
https://doi.org/10.1016/j.ejmech.2017.03.017
Autor:
Akira Asai, Naoya Suehiro, Yoshiaki Masuda, Daisuke Muraoka, Tatsuya Koseki, Naohisa Ogo, Nao Miyoshi
Publikováno v:
Biologicalpharmaceutical bulletin. 42(5)
Signal transducer and activator of transcription 3 (STAT3) is a latent transcription factor that contributes to tumor cell growth and survival and is often constitutively active in several types of cancers, which makes it an attractive target for can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c8697cfb32679c1411e53b691f053f
https://pubmed.ncbi.nlm.nih.gov/31061322
https://pubmed.ncbi.nlm.nih.gov/31061322
Autor:
Akira Asai, Masayoshi Yamane, Jun-ichi Sawada, Hisashi Murakami, Naohisa Ogo, Nao Miyoshi, Taiki Ichida, Ryota Fukai
Publikováno v:
European Journal of Medicinal Chemistry. 215:113288
Kinesin spindle protein (KSP) is expressed only in cells undergoing cell division, and hence represents an attractive target for the treatment of cancer. Several KSP inhibitors have been developed and undergone clinical trial, but their clinical use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::125f084ac53e73fffecc848dc9c04c0c
https://doi.org/10.1016/j.ejmech.2021.113288
https://doi.org/10.1016/j.ejmech.2021.113288
Autor:
Nao Miyoshi, Fumiyasu Momose, Akira Asai, Hajime Kashima, Naozumi Harada, Hiroshi Umehara, Daisuke Muraoka, Hiroshi Shiku, Naohisa Ogo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0156643 (2016)
PLoS ONE, Vol 11, Iss 6, p e0156643 (2016)
Forkhead box protein p3 (Foxp3) is crucial to the development and suppressor function of regulatory T cells (Tregs) that have a significant role in tumor-associated immune suppression. Development of small molecule inhibitors of Foxp3 function is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a3d0b74a3be2bffc9972ec1f1d99d9
https://pubmed.ncbi.nlm.nih.gov/27284967
https://pubmed.ncbi.nlm.nih.gov/27284967
Publikováno v:
Catalysis Letters. 141:877-881
We synthesized Ca-containing FSM-16 (Ca-FSM-16) for use as a solid base catalyst for the Knoevenagel condensation reaction. Extended X-ray absorption fine structure (EXAFS) results indicated that Ca species were introduced as a calcium silicate-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7922daced311f29c1eef1cd47e9563f4
https://doi.org/10.1007/s10562-011-0613-3
https://doi.org/10.1007/s10562-011-0613-3