Výsledky vyhledávání - "Nao Matsuoka"

Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation

Autor: Yoshinobu Takakura, Makiya Nishikawa, Nao Matsuoka, Mitsuhiro Matono, Sakulrat Rattanakiat

Publikováno v: Immunology. 124:247-255

DNA containing unmethylated CpG dinucleotides (CpG DNA) is a potent activator of innate and acquired immune responses. Although the sequence-specific immunostimulatory activity of CpG DNA has been extensively explored, little information is available

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf27c8813afc6928f1b602751afda9de
https://doi.org/10.1111/j.1365-2567.2007.02762.x

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Design and development of nanosized DNA assemblies in polypod-like structures as efficient vehicles for immunostimulatory CpG motifs to immune cells

Autor: Makiya Nishikawa, Kumi Hidaka, Yoshinobu Takakura, Tomoki Shiomi, Kohta Mohri, Yuki Takahashi, Hiroshi Sugiyama, Kohei Ogawa, Nao Matsuoka, Masayuki Endo, Natsuki Takahashi

Publikováno v: ACS nano. 6(7)

The immunostimulatory activity of phosphodiester DNA containing unmethylated cytosine-phosphate-guanine (CpG) dinucleotides, or CpG motifs, was significantly increased by the formation of Y-, X-, or dendrimer-like multibranched shape. These results s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9828638bf6e2a221de4f63d6b41a1cf3
https://pubmed.ncbi.nlm.nih.gov/22721419

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Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice

Autor: Nao Matsuoka, Kohta Mohri, Dan Luo, Yumiko Mizuno, Makiya Nishikawa, Hisakage Funabashi, Yuki Takahashi, Sakulrat Rattanakiat, Yoshinobu Takakura

Publikováno v: Biomaterials.

Immunostimulatory CpG DNA was self-assembled to form DNA hydrogels for use as a sustained delivery system for both intercalated doxorubicin (DXR) and immunostimulatory CpG motifs for cancer treatment. X-shaped DNA (X-DNA) was designed as a building u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7acd114ea990c6205787074efa9ee69
http://hdl.handle.net/2433/131741

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Structural and immunostimulatory properties of Y-shaped DNA consisting of phosphodiester and phosphorothioate oligodeoxynucleotides

Autor: Makiya Nishikawa, Yoshinobu Takakura, Sakulrat Rattanakiat, Kohta Mohri, Nao Matsuoka

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 148(3)

Y-shape formation increased the immunostimulatory activity of phosphodiester (PO) oligodeoxynucleotides (ODNs) containing CpG motif. In this study, PO CpG ODN or CpG ODN containing nuclease-resistant phosphorothioate (PS) linkages, i.e., PS CpG ODN o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496d236fa8158b40b1e7715ca2d5a56a
https://pubmed.ncbi.nlm.nih.gov/20887761

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Understanding externalizing behavior from children's personality and parenting characteristics

Autor: Masayo Uji, Noriko Shikai, Toshinori Kitamura, Zhiyong Chen, Nao Matsuoka, Hidetoshi Hiramura

Publikováno v: Psychiatry research. 175(1-2)

A total of 946 Japanese children in the 5th to 9th grades and their parents were studied in order to investigate the extent to which parenting characteristics (measured by the Parental Bonding Instrument) and the personality of the child (measured by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bb9e3e31f0ef157ed7fa1918c82a9d
https://pubmed.ncbi.nlm.nih.gov/19963278

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Laser-assisted biomimetic process for surface functionalization of titanium metal

Autor: Atsuo Ito, Yoshiki Shimizu, Maki Nakamura, Nao Matsuoka, Naoto Koshizaki, Kenji Koga, Kenji Kawaguchi, Hidero Unuma, Ayako Oyane, Yu Sogo

Publikováno v: Colloids and Interface Science Communications. :5-9

Biomimetic calcium phosphate (CaP) precipitation processes using supersaturated CaP solutions are useful in surface functionalization of biomedical materials. We applied our laser-assisted biomimetic (LAB) process to successfully achieve rapid single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f61240c1d2cbb39f8f9cc1af4c6f498

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