Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Nao Jounai"'
Autor:
Shiho Chiba, Maki Kiso, Shinya Yamada, Kazuhiko Someya, Yoshikuni Onodera, Aya Yamaguchi, Satoko Matsunaga, Nao Jounai, Seiya Yamayoshi, Fumihiko Takeshita, Yoshihiro Kawaoka
Publikováno v:
EBioMedicine, Vol 109, Iss , Pp 105408- (2024)
Externí odkaz:
https://doaj.org/article/68e82a52a4d34e5697141817636c704d
Autor:
Ryuta Uraki, Masaki Imai, Mutsumi Ito, Seiya Yamayoshi, Maki Kiso, Nao Jounai, Kazuki Miyaji, Kiyoko Iwatsuki-Horimoto, Fumihiko Takeshita, Yoshihiro Kawaoka
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-10 (2024)
Abstract Here, we assessed the efficacy of a lipid nanoparticle-based mRNA vaccine candidate encoding the receptor-binding domain (LNP-mRNA-RBD) in mice. Mice immunized with LNP-mRNA-RBD based on the ancestral strain (ancestral-type LNP-mRNA-RBD) sho
Externí odkaz:
https://doaj.org/article/427759ac641440db840a7f2931caa239
Autor:
Nao Jounai, Megumi Yoshioka, Miyuki Tozuka, Kazue Inoue, Tatsuya Oka, Kazuki Miyaji, Katsuyasu Ishida, Naoki Kawai, Hideyuki Ikematsu, Chiaki Kawakami, Hiroyuki Shimizu, Masaaki Mori, Ken J. Ishii, Fumihiko Takeshita
Publikováno v:
EBioMedicine, Vol 16, Iss C, Pp 124-135 (2017)
Respiratory syncytial virus (RSV) is one of the most prevalent causative agents of lower respiratory tract infections worldwide, especially in infants around 3 to 4 months old. Infants at such a young age have maternally-transferred passive antibodie
Externí odkaz:
https://doaj.org/article/b40c38bc15cb4dbab430c322580a0d67
Publikováno v:
EBioMedicine, Vol 9, Iss C, Pp 87-96 (2016)
The innate immune protein Stimulator of interferon genes (STING) promotes the induction of interferon beta (IFN-β) production via the phosphorylation of its C-terminal tail (CTT) by TANK-binding kinase 1 (TBK1). Potent ligands of STING are, therefor
Externí odkaz:
https://doaj.org/article/d8380d829043433bb61eba1b0b813085
Autor:
Choon Kit Tang, Taiki Aoshi, Nao Jounai, Junichi Ito, Keiichi Ohata, Kouji Kobiyama, Benoit H Dessailly, Etsushi Kuroda, Shizuo Akira, Kenji Mizuguchi, Cevayir Coban, Ken J Ishii
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60038 (2013)
5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a potent type I interferon (IFN) inducer, was evaluated as a chemotherapeutic agent in mouse cancer models and proved to be well tolerated in human cancer clinical trials. Despite its multiple biological
Externí odkaz:
https://doaj.org/article/ea094f7d4bfb48cf9ac352f2617c01e1
Autor:
Burcu Temizoz, Kou Hioki, Shingo Kobari, Nao Jounai, Takato Kusakabe, Michelle S J Lee, Cevayir Coban, Etsushi Kuroda, Ken J Ishii
Publikováno v:
International immunology. 34(7)
Agonists for TLR9 and stimulator of IFN genes (STING) offer therapeutic applications as both anti-tumor agents and vaccine adjuvants, though their clinical applications are limited; the clinically available TLR9 agonist is a weak IFN inducer and STIN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c210e19a00f8d1460f87e4c8307f81f
https://pubmed.ncbi.nlm.nih.gov/35419609
https://pubmed.ncbi.nlm.nih.gov/35419609
Autor:
Yasushi Itoh, Kiyoko Iwatsuki-Horimoto, Mutsumi Ito, Nao Jounai, Hioki Kou, Seiya Yamayoshi, Yoshinori Kitagawa, Takako Niwa, Fumihiko Takeshita, Takashi Suzuki, Yoshihiro Kawaoka, Misako Nakayama, Kouji Kobiyama, Ken Ishii, Shintaro Yamada, Temizoz B, Negishi H, Tsuchida J, Masayuki Imai, Cong Thanh Nguyen, Tomoyuki Watanabe, Maki Kiso, Hirohito Ishigaki
In 2020, two mRNA-based vaccines, encoding the full length of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, have been introduced for control of the coronavirus disease (COVID-19) pandemic1,2. However, reactogenicity, suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd11c0de312341e4921d646e7f6a6b3e
https://doi.org/10.1101/2021.03.04.433852
https://doi.org/10.1101/2021.03.04.433852
Publikováno v:
EBioMedicine
EBioMedicine, Vol 9, Iss C, Pp 87-96 (2016)
EBioMedicine, Vol 9, Iss C, Pp 87-96 (2016)
The innate immune protein Stimulator of interferon genes (STING) promotes the induction of interferon beta (IFN-β) production via the phosphorylation of its C-terminal tail (CTT) by TANK-binding kinase 1 (TBK1). Potent ligands of STING are, therefor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1be55d63b960df4ee724641479cc31
https://doi.org/10.1016/j.ebiom.2016.05.039
https://doi.org/10.1016/j.ebiom.2016.05.039
Autor:
Fumihiko Takeshita, Kenji Kabashima, Miyuki Tozuka, Nao Jounai, Ken Ishii, Tatsuya Oka, Gyohei Egawa
Publikováno v:
Journal of Dermatological Science. 82:38-45
Background It has been clinically demonstrated that intradermal (ID) vaccines have a potential to confer a superior immunogenic profile compared to intramuscular (IM) or subcutaneous (SC) vaccines. In terms of distribution of a vaccine antigen depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2be217dfe937536764515058ccd282c
https://doi.org/10.1016/j.jdermsci.2015.11.008
https://doi.org/10.1016/j.jdermsci.2015.11.008
Autor:
Burcu Temizoz, Ken Ishii, Kouji Kobiyama, Taiki Aoshi, Etsushi Kuroda, Koji Ozasa, Nao Jounai, Keiichi Ohata
Publikováno v:
European Journal of Immunology
Agonists for TLR9 and Stimulator of IFN Gene (STING) act as vaccine adjuvants that induce type-1 immune responses. However, currently available CpG oligodeoxynucleotide (ODN) (K-type) induces IFNs only weakly and STING ligands rather induce type-2 im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ce350daf6c297e2f75247603e04a88
http://europepmc.org/articles/PMC4671267
http://europepmc.org/articles/PMC4671267