Výsledky vyhledávání

Akademický článek

Novel Brain-Penetrant, Small-Molecule Tubulin Destabilizers for the Treatment of Glioblastoma

Autor: Lilian A. Patrón, Helen Yeoman, Sydney Wilson, Nanyun Tang, Michael E. Berens, Vijay Gokhale, Teri C. Suzuki

Publikováno v: Biomedicines, Vol 12, Iss 2, p 406 (2024)

Glioblastoma (GB) is the most lethal brain cancer in adults, with a 5-year survival rate of 5%. The standard of care for GB includes maximally safe surgical resection, radiation, and temozolomide (TMZ) therapy, but tumor recurrence is inevitable in m

Externí odkaz: https://doaj.org/article/1c13069713c0462e862226d57ef4f263

Zobrazit plný text záznamu

Akademický článek

High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes

Autor: Michelle Kassner, J. Brek Eaton, Nanyun Tang, Joachim L. Petit, Nathalie Meurice, Hongwei Holly Yin, Paul Whiteaker

Publikováno v: SLAS Discovery, Vol 27, Iss 1, Pp 68-76 (2022)

There is substantial evidence that in addition to nicotine, other compounds found in tobacco smoke significantly influence smoking behavior. Further, recent years have seen an explosion in the availability of non-combusted products that deliver nicot

Externí odkaz: https://doaj.org/article/69bed0571f2b4e86ad58d7d3b8564877

Zobrazit plný text záznamu

Akademický článek

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

Publikováno v: Cell Reports, Vol 35, Iss 13, Pp 109291- (2021)

Summary: To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative a

Externí odkaz: https://doaj.org/article/24ff658919d8494e80b28117e73c541b

Zobrazit plný text záznamu

Table S3 from Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition

IC50 summary of validated drug hits in SCCOHT cell lines.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38616ea70cb460eabed4bb61f65d7345
https://doi.org/10.1158/1078-0432.22464359.v1

Zobrazit plný text záznamu

Data from Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition

Purpose: Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, aggressive ovarian cancer in young women that is universally driven by loss of the SWI/SNF ATPase subunits SMARCA4 and SMARCA2. A great need exists for effective targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf4fffb94e0c2d32e4dcebc100aa969
https://doi.org/10.1158/1078-0432.c.6525683.v1

Zobrazit plný text záznamu

Figures S1-3 from Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition

Supplemental Figure 1. COV434-pIND20-Brg1 SMARCA4 induction optimization; Supplemental Figure 2. Kinase hits from siRNA screen mapped to kinome dendrogram; Supplemental Figure 3. ClueGo analysis of validated siRNA screen hits.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500ec18fb2328ea3d8b543cf0fd9e555
https://doi.org/10.1158/1078-0432.22464371.v1

Zobrazit plný text záznamu

Table S5-6 from Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition

Supplemental Table 5. SCCOHT-1 ABPP data; Supplemental Table 6. BIN67 ABPP data.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1308cedc68ea73c726a08bb157a719a4
https://doi.org/10.1158/1078-0432.22464353.v1

Zobrazit plný text záznamu

Supplemental Methods from Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition

Supplemental Materials and Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c619d170ae7b727c213ce8cc3e78419
https://doi.org/10.1158/1078-0432.22464368

Zobrazit plný text záznamu

Retracted: PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors

Autor: Shayesteh R Ferdosi, Brett Taylor, Matthew Lee, Nanyun Tang, Sen Peng, Rita Bybee, George Reid, Lauren Hartman, Krystine Garcia-Mansfield, Ritin Sharma, Patrick Pirrotte, Jianhui Ma, Alison D Parisian, Frank Furnari, Harshil D Dhruv, Michael E Berens

Publikováno v: Neuro-Oncology. 24:1857-1868

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c1856c089bc501125d86d886e459c11
https://doi.org/10.1093/neuonc/noac067

Zobrazit plný text záznamu

Abstract 1601: Potentiation of arsenic trioxide in glioblastoma

Autor: Charles Shaffer, Nanyun Tang, Yue Hao, Karen Fink, George Snipes, Bruce Mickey, Michael Berens

Publikováno v: Cancer Research. 83:1601-1601

Glioblastoma (GBM) is the most prevalent type of malignant tumor within the central nervous system. Possessing a five-year survival rate of 6.8%, new therapeutic options are a necessity in order to increase patient quality of life and survival outcom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a401b278436c43857e9ccbd14bcc391
https://doi.org/10.1158/1538-7445.am2023-1601

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání