Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank

Autor: Codd, V, Denniff, M, Swinfield, C, Warner, SC, Papakonstantinou, M, Sheth, S, Nanus, DE, Budgeon, CA, Musicha, C, Bountziouka, V, Wang, Q, Bramley, R, Allara, E, Kaptoge, S, Stoma, S, Jiang, T, Butterworth, AS, Wood, AM, Di Angelantonio, E, Thompson, Danesh, JN, Nelson, CP, Samani, NJ

Leukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We confirm that older age and male sex associate with shorter LTL, with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a41e34651b9d7beb69733b6fd39887b
https://www.repository.cam.ac.uk/handle/1810/332822

Differential glucocorticoid metabolism in patients with persistent versus resolving inflammatory arthritis

Autor: Nanus, DE, Filer, AD, Yeo, L, Scheel-Toellner, D, Hardy, R, Lavery, GG, Stewart, PM, Buckley, CD, Tomlinson, JW, Cooper, MS, Raza, K

Publikováno v: Arthritis Research & Therapy. 17(1)

Introduction: Impairment in the ability of the inflamed synovium to generate cortisol has been proposed to be a factor in the persistence and severity of inflammatory arthritis. In the inflamed synovium, cortisol is generated from cortisone by the 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::865e95c11275d6dc0e1b7135bff610b0

The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence.

Autor: Wijesinghe SN; Institute of Inflammation and Ageing, MRC- Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, United Kingdom., Anderson J; Institute of Life Course and Medical Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom., Brown TJ; School of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom., Nanus DE; Institute of Inflammation and Ageing, MRC- Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, United Kingdom., Housmans B; Laboratory for Experimental Orthopedics, Department of Orthopedic Surgery, Maastricht University Medical Center, Maastricht, Netherlands., Green JA; University of Liverpool, Liverpool, United Kingdom., Hackl M; TAmiRNA GmbH, Vienna, Austria., Choi KK; School of Medicine, University of Nottingham, Nottingham, United Kingdom., Arkill KP; School of Medicine, University of Nottingham, Nottingham, United Kingdom., Welting T; Laboratory for Experimental Orthopedics, Department of Orthopedic Surgery, Maastricht University Medical Center, Maastricht, Netherlands., James V; School of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom., Jones SW; Institute of Inflammation and Ageing, MRC- Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, United Kingdom., Peffers MJ; Institute of Life Course and Medical Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.

Publikováno v: Frontiers in molecular biosciences [Front Mol Biosci] 2022 Sep 23; Vol. 9, pp. 971621. Date of Electronic Publication: 2022 Sep 23 (Print Publication: 2022).

Polygenic basis and biomedical consequences of telomere length variation.

Autor: Codd V; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. vc15@le.ac.uk.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK. vc15@le.ac.uk., Wang Q; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Allara E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK., Musicha C; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kaptoge S; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK., Stoma S; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Jiang T; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Hamby SE; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Bountziouka V; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Budgeon CA; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.; School of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia., Denniff M; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Swinfield C; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Papakonstantinou M; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Sheth S; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Nanus DE; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Warner SC; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Wang M; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Khera AV; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Eales J; Division of Cardiovascular Sciences, University of Manchester, Manchester, UK., Ouwehand WH; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; NHS Blood and Transplant, Cambridge, UK.; University College London Hospitals NHS Foundation Trust, London, UK., Thompson JR; Department of Health Sciences, University of Leicester, Leicester, UK., Di Angelantonio E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Sanger Institute, EMBL-European Bioinformatics Institute and University of Cambridge, Cambridge, UK., Wood AM; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Sanger Institute, EMBL-European Bioinformatics Institute and University of Cambridge, Cambridge, UK.; The Alan Turing Institute, London, UK., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Sanger Institute, EMBL-European Bioinformatics Institute and University of Cambridge, Cambridge, UK., Danesh JN; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Sanger Institute, EMBL-European Bioinformatics Institute and University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. njs@le.ac.uk.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK. njs@le.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2021 Oct; Vol. 53 (10), pp. 1425-1433. Date of Electronic Publication: 2021 Oct 05.

The Expression and Function of Metastases Associated Lung Adenocarcinoma Transcript-1 Long Non-Coding RNA in Subchondral Bone and Osteoblasts from Patients with Osteoarthritis.

Autor: Alnajjar FA; Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham B15 2TT, UK., Sharma-Oates A; Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham B15 2TT, UK., Wijesinghe SN; Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham B15 2TT, UK., Farah H; Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham B15 2TT, UK., Nanus DE; Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham B15 2TT, UK., Nicholson T; Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham B15 2TT, UK., Davis ET; The Royal Orthopaedic Hospital, Birmingham B31 2AP, UK., Jones SW; Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham B15 2TT, UK.

Publikováno v: Cells [Cells] 2021 Apr 01; Vol. 10 (4). Date of Electronic Publication: 2021 Apr 01.