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Two new isoquinoline alkaloids from the seeds of Nandina domestica

Autor: Li-Feng Chen, Neng-Hua Chen, Yu-Bo Zhang, Yao-Lan Li, Ding Luo, Sheng-Yuan Zhang, Guo-Cai Wang, Zhong-Nan Wu, Juan Qin

Publikováno v: Natural Product Research. 35:3254-3260

Two new isoquinoline alkaloids, 6 R,6aS-N-nantenine Nβ-oxide (1), 6S,6aS-N-nantenine Nα-oxide (2), along with nine known alkaloids, nantenine (3), oxonantenine (4), protopine (5), nornantenine (6),...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cacd874fd000126c95ebcbcf716bd51
https://doi.org/10.1080/14786419.2019.1696334

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Akademický článek

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Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT2A receptor

Autor: Nirav Kapadia, Shashikanth Ponnala, Ian Alberts, Sudharshan Madapa, Wayne W. Harding

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 25:5102-5106

A series of C1 aporphine analogues related to compound 5 and that contain substituted allylic, alkynyl, nitrile, ester and benzyl groups was synthesized and evaluated for affinity at h5HT2A and α1A receptors in functional activity assays that measur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a17f9b5eba08f6b0ec670e0b55824b0
https://doi.org/10.1016/j.bmcl.2015.10.012

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Evaluation of structural effects on 5-HT2A receptor antagonism by aporphines: Identification of a new aporphine with 5-HT2A antagonist activity

Autor: Shashikanth Ponnala, Wayne W. Harding, Hernán A. Navarro, Junior Gonzales, Nirav Kapadia

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 24:1664-1667

A set of aporphine analogs related to nantenine was evaluated for antagonist activity at 5-HT2A and α1A adrenergic receptors. With regards to 5-HT2A receptor antagonism, a C2 allyl group is detrimental to activity. The chiral center of nantenine is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382e2d9ad58858392ddafe045cafbf0b
https://doi.org/10.1016/j.bmcl.2014.02.066

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Akademický článek

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Extract from Nandina domestica Inhibits Lipopolysaccharide-Induced Cyclooxygenase-2 Expression in Human Pulmonary Epithelial A549 Cells

Autor: Takuro Ueki, Kazuho Abe, Hidenobu Okumura, Tatsuhiro Akaishi

Publikováno v: Biological and Pharmaceutical Bulletin. 35:1041-1047

Extract from fruits of Nandina domestica THUNBERG (NDE) has been used to improve cough and breathing difficulty in Japan for many years. To explore whether NDE may alleviate respiratory inflammation, we investigated its effect on expression of cycloo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72e3aba943d20764b07cf26a912f9c54
https://doi.org/10.1248/bpb.b110709

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Biphasic Tracheal Relaxation Induced by Higenamine and Nantenine From Nandina domestica THUNBERG

Autor: Tsuneo Morioka, Kazuho Abe, Takuro Ueki, Tatsuhiro Akaishi, Hidenobu Okumura

Publikováno v: Journal of Pharmacological Sciences, Vol 115, Iss 2, Pp 254-257 (2011)

We compared the effects of the extract from fruits of Nandina domestica THUNBERG (NDE) and its constituents, higenamine and nantenine, on contractile responses in isolated guineapig trachea. NDE (1 mg/ml) caused biphasic relaxation of the trachea pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b65862ea98dffb37dc3abbc9bbf3a4
https://doi.org/10.1254/jphs.10251sc

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Affinity of aporphines for the human 5-HT2A receptor: Insights from homology modeling and molecular docking studies

Autor: Hernán A. Navarro, Boojala Vijay B. Reddy, Wayne W. Harding, Pooja Makkar, Sandeep Chaudhary, Stevan Pecic

Publikováno v: Bioorganic & Medicinal Chemistry. 18:5562-5575

Analogs of nantenine were docked into a modeled structure of the human 5-HT(2A) receptor using ICM Pro, GLIDE, and GOLD docking methods. The resultant docking scores were used to correlate with observed in vitro apparent affinity (K(e)) data. The GOL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef26ed01e37d4b0aece724271b6f955
https://doi.org/10.1016/j.bmc.2010.06.043

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β2-Adrenoceptor-Mediated Tracheal Relaxation Induced by Higenamine fromNandina domesticaThunberg

Autor: Kazuho Abe, Tatsuhiro Akaishi, Hiroko Kikuchi, Hidenobu Okumura, Takuro Ueki, Yoichi Yasuda, Muneo Tsukiyama

Publikováno v: Planta Medica. 75:1393-1399

The fruit of Nandina domestica Thunberg (ND, Berberidaceae) has been used to improve cough and breathing difficulties in Japan for many years, but very little is known about the constituent of ND responsible for this effect. We have recently reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc788aaa1f321c02081355fafae94da
https://doi.org/10.1055/s-0029-1185743

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