Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Nanni Huser"'
Autor:
Cathy C Zhang, Zhengming Yan, Bernadette Pascual, Amy Jackson-Fisher, Donghui Stephen Huang, Qing Zong, Mark Elliott, Conglin Fan, Nanni Huser, Joseph Lee, Matthew Sung, Puja Sapra
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 1, Pp 1-11 (2018)
Gemtuzumab ozogamicin (GO) is an anti-CD33 antibody-drug conjugate for the treatment of acute myeloid leukemia (AML). Although GO shows a narrow therapeutic window in early clinical studies, recent reports detailing a modified dosing regimen of GO ca
Externí odkaz:
https://doaj.org/article/2898acde00d048cd84c53471b28d4128
Autor:
Shu-Hui Liu, Yin Gu, Bernadette Pascual, Zhengming Yan, Max Hallin, Cathy Zhang, Conglin Fan, Wenlian Wang, Justine Lam, Mary E. Spilker, Rolla Yafawi, Eileen Blasi, Brett Simmons, Nanni Huser, Wei-Hsien Ho, Kevin Lindquist, Thomas-Toan Tran, Jyothirmayee Kudaravalli, Jing-Tyan Ma, Gretchen Jimenez, Ishita Barman, Colleen Brown, Sherman Michael Chin, Maria J. Costa, David Shelton, Tod Smeal, Valeria R. Fantin, Flavia Pernasetti
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 1088-1100 (2017)
Abstract: The chemokine receptor CXCR4 is highly expressed and associated with poor prognosis in multiple malignancies. Upon engagement by its ligand, CXCL12, CXCR4 triggers intracellular signaling pathways that control trafficking of cells to tissue
Externí odkaz:
https://doaj.org/article/6df94e3160ac4a0297441615788d740b
Autor:
Natasha Emmanuel, Shoba Ragunathan, Qin Shan, Fang Wang, Andreas Giannakou, Nanni Huser, Guixian Jin, Jeremy Myers, Robert T. Abraham, Keziban Unsal-Kacmaz
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2665-2680 (2017)
Pharmacologic agents that interfere with nucleotide metabolism constitute an important class of anticancer agents. Recent studies have demonstrated that mTOR complex 1 (mTORC1) inhibitors suppress de novo biosynthesis of pyrimidine and purine nucleot
Externí odkaz:
https://doaj.org/article/cd510adcb17843e78a10f0a4f7636bc6
Autor:
Manoj K. Kashyap, Carlos I. Amaya-Chanaga, Deepak Kumar, Brett Simmons, Nanni Huser, Yin Gu, Max Hallin, Kevin Lindquist, Rolla Yafawi, Michael Y. Choi, Ale-Ali Amine, Laura Z. Rassenti, Cathy Zhang, Shu-Hui Liu, Tod Smeal, Valeria R. Fantin, Thomas J. Kipps, Flavia Pernasetti, Januario E. Castro
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-16 (2017)
Abstract Background The CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported in different hematological malignancies including CLL. Binding of the
Externí odkaz:
https://doaj.org/article/c1cbefb66ea643659235e75122642524
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
Drug combination therapies are commonly used for the treatment of cancers to increase therapeutic efficacy, reduce toxicity, and decrease the incidence of drug resistance. Although drug combination therapies were originally devised primarily by empir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009230c7b846415ab8368b86d944ad43
https://doi.org/10.1158/1535-7163.c.6536134.v1
https://doi.org/10.1158/1535-7163.c.6536134.v1
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 148K, The effects of CK2, MDC1 or XRCC1 depletion by siRNA on Gamma-H2AX levels induced by cisplatin or gemcitabine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fb6cb4e739d4f966916283f31a97e5
https://doi.org/10.1158/1535-7163.22499401.v1
https://doi.org/10.1158/1535-7163.22499401.v1
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 63K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1724ae25a140fdf37ff1525f0a31ef0d
https://doi.org/10.1158/1535-7163.22499395
https://doi.org/10.1158/1535-7163.22499395
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 97K, Quantified western blots for Gamma-H2AX and cleaved PARP levels normalized to �eta-actin levels from cisplatin or gemcitabine combinations with CX-4945.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e37083b780678c4a83fbc6e1748ed1
https://doi.org/10.1158/1535-7163.22499404.v1
https://doi.org/10.1158/1535-7163.22499404.v1
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 1.0MB, The global role of CK2 in DNA repair and cancer therapies that potentially rely on CK2 mediated repair mechanisms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d9190126d915dc4ca655ca09925838
https://doi.org/10.1158/1535-7163.22499398
https://doi.org/10.1158/1535-7163.22499398
Autor:
Kenna Anderes, William G. Rice, David M. Ryckman, Michael K. Schwaebe, Chris Proffitt, Caroline Ho, Nanni Huser, Mayuko Omori, Josh Bliesath, Sean E. O'Brien, Fabrice Pierre, Peter Chua, Nicole Streiner, Denis Drygin, Adam Siddiqui-Jain
Supplementary Methods from CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5cc2abcc1fc3202335d6528f4c2a9a
https://doi.org/10.1158/0008-5472.22386579
https://doi.org/10.1158/0008-5472.22386579