Examining extended human leukocyte antigen-G and HLA-F haplotypes: the HLA-G UTR-4 haplotype is associated with shorter time to pregnancy in an infertility treatment setting when both female and male partners are carriers

Autor: Line Lynge Nilsson, Thomas Vauvert F. Hviid, Trine L. Perin, Thomas H. Scheike, Nanna K. Jorgensen, Cæcilie H. Langkilde, Tina Funck, Micha B. Hornstrup, Anette Lindhard

Publikováno v: Fertility and Sterility. 114:628-639

Objective To study the impact of extended human leukocyte antigen (HLA)-G and HLA-F haplotypes on time to pregnancy as measured by the number of treatment cycles in a cohort of couples in infertility treatment. Design Prospective cohort study of coup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94f13fe2b9d52cf377cb89ea63b18ef
https://doi.org/10.1016/j.fertnstert.2020.04.052

Tumour-infiltrating CD4-, CD8- and FOXP3-positive immune cells as predictive markers of mortality in BRCA1- and BRCA2-associated breast cancer

Autor: Ida Marie Heeholm Sonderstrup, Mads Thomassen, Nanna K. Jorgensen, Lise B. Nielsen, Bent Ejlertsen, Jens Eriksen, Maj-Britt Jensen, Anne-Marie Gerdes, Torben A Kruse, Thomas Vauvert F. Hviid, Anne Vibeke Lænkholm

Publikováno v: Jørgensen, N, Hviid, T V F, Nielsen, L B, Sønderstrup, I M H, Eriksen, J O, Ejlertsen, B, Gerdes, A M, Kruse, T A, Thomassen, M, Jensen, M B & Lænkholm, A V 2021, ' Tumour-infiltrating CD4-, CD8-and FOXP3-positive immune cells as predictive markers of mortality in BRCA1-and BRCA2-associated breast cancer ', British Journal of Cancer, vol. 125, no. 10, pp. 1388-1398 . https://doi.org/10.1038/s41416-021-01514-7
Br J Cancer

Background: The prognostic value of tumour-infiltrating lymphocytes (TILs) in breast cancer is well-established. However, the investigation of specific T-cell subsets exclusively in BRCA-associated breast cancer is sparse. Methods: Tumour tissues fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646958fbe222923a8eaccce111e0a5a3
https://portal.findresearcher.sdu.dk/da/publications/7c9435ff-8a2a-4f82-87e0-7e6e0e63800e

Characterization of HLA-G Regulation and HLA Expression in Breast Cancer and Malignant Melanoma Cell Lines upon IFN-γ Stimulation and Inhibition of DNA Methylation

Autor: Thomas Vauvert F. Hviid, Iben Weisdorf, Abid Sayed, G. Persson, Helene Bjerregaard Jeppesen, Nanna K. Jorgensen, Tina Funck

Publikováno v: Jørgensen, N, Sayed, A, Jeppesen, H B, Persson, G, Weisdorf, I, Funck, T & Hviid, T V F 2020, ' Characterization of HLA-G Regulation and HLA Expression in Breast Cancer and Malignant Melanoma Cell Lines upon IFN-γ Stimulation and Inhibition of DNA Methylation ', International Journal of Molecular Sciences (Online), vol. 21, no. 12, 4307 . https://doi.org/10.3390/ijms21124307
International Journal of Molecular Sciences
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4307, p 4307 (2020)

The potential role of human leukocyte antigen (HLA)-G as a target for new cancer immunotherapy drugs has increased the interest in the analysis of mechanisms by which HLA-G expression is regulated, and how the expression can be manipulated. We charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de555b116eff8aa5ff3aca3059a4898c
https://curis.ku.dk/portal/da/publications/characterization-of-hlag-regulation-and-hla-expression-in-breast-cancer-and-malignant-melanoma-cell-lines-upon-ifn-stimulation-and-inhibition-of-dna-methylation(13c8b8aa-ba28-4f80-85a7-3fda890a68fb).html

Modulation of KCNQ4 channel activity by changes in cell volume

Autor: Charlotte Hougaard, Søren-Peter Olesen, Else K. Hoffmann, Dan A. Klaerke, Nanna K. Jorgensen

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1660:1-6

KCNQ4 channels expressed in HEK 293 cells are sensitive to cell volume changes, being activated by swelling and inhibited by shrinkage, respectively. The KCNQ4 channels contribute significantly to the regulatory volume decrease (RVD) process followin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa914d68db0624677579985ec1ef4170
https://doi.org/10.1016/j.bbamem.2003.11.015

Inhibition of the human intermediate-conductance, Ca2+-activated K+ channel by intracellular acidification

Autor: Nanna K. Jorgensen, Kamilla Angelo Pedersen, Søren-Peter Olesen, Bo Skaaning Jensen

Publikováno v: Pflügers Archiv - European Journal of Physiology. 440:153-156

The effect of changes in pH on the gating properties of the cloned human intermediate-conductance, Ca2+-activated K+ channel (hIK) was studied using the patch-clamp technique. Multi-channel inside-out recordings of patches from HEK-293 cells stably e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff70a6ec7021fbc8251d2d5556184b18
https://doi.org/10.1007/s004240000269