The BNT162b2 mRNA vaccine demonstrates reduced age-associated T H 1 support in vitro and in vivo .

Autor: Brook B; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Checkervarty AK; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.; Prevention of Organ Failure (PROOF) Centre of Excellence, St Paul's Hospital, University of British Columbia, Vancouver, BC V6Z 2K5, Canada.; UBC Centre for Heart Lung Innovation, Providence Research, St Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada., Barman S; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Sweitzer C; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA., Bosco AN; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA., Sherman AC; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Medicine, Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA., Baden LR; Department of Medicine, Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA., Morrocchi E; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.; Research Unit of Clinical Immunology and Vaccinology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy., Sanchez-Schmitz G; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Palma P; Research Unit of Clinical Immunology and Vaccinology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.; Department of Systems Medicine- Chair of Pediatrics, University of Rome, 00133 Tor Vergata, Italy., Nanishi E; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., O'Meara TR; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA., McGrath ME; Center for Pathogen Research, Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD 21201, USA., Frieman MB; Center for Pathogen Research, Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, MD 21201, USA., Soni D; Global Investigative Toxicology, Preclinical Safety, Sanofi, Cambridge, MA 02142, USA., van Haren SD; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Ozonoff A; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA., Diray-Arce J; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Steen H; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA., Dowling DJ; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Levy O; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA.

Publikováno v: IScience [iScience] 2024 Sep 26; Vol. 27 (11), pp. 111055. Date of Electronic Publication: 2024 Sep 26 (Print Publication: 2024).

From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation.

Autor: Soni D; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Borriello F; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Scott DA; Harvard Medical School, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Feru F; Harvard Medical School, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., DeLeon M; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Brightman SE; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA., Cheng WK; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Melhem G; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Smith JA; Harvard Medical School, Boston, MA, USA., Ramirez JC; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Barman S; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cameron M; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., Kelly A; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA., Walker K; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA., Nanishi E; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., van Haren SD; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Phan T; Access to Advanced Health Institute (AAHI), Seattle, WA, USA., Qi Y; Access to Advanced Health Institute (AAHI), Seattle, WA, USA., Kinsey R; Access to Advanced Health Institute (AAHI), Seattle, WA, USA., Raczy MM; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Ozonoff A; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT & Harvard, Cambridge, MA, USA., Pettengill MA; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Hubbell JA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Fox CB; Access to Advanced Health Institute (AAHI), Seattle, WA, USA.; Department of Global Health, University of Washington, 3980 15th Ave NE, Seattle, WA 98195, USA., Dowling DJ; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Levy O; Precision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT & Harvard, Cambridge, MA, USA.

Publikováno v: Science advances [Sci Adv] 2024 Jul 05; Vol. 10 (27), pp. eadg3747. Date of Electronic Publication: 2024 Jul 03.

Precision Vaccinology Approaches for the Development of Adjuvanted Vaccines Targeted to Distinct Vulnerable Populations.

Autor: Lee B; Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA., Nanishi E; Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Levy O; Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Dowling DJ; Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

Publikováno v: Pharmaceutics [Pharmaceutics] 2023 Jun 19; Vol. 15 (6). Date of Electronic Publication: 2023 Jun 19.

Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice.

Autor: Nanishi E; Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Borriello F; Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Division of Immunology, Boston Children's Hospital, Boston, MA, USA.; Generate Biomedicines, Cambridge, MA, USA., Seo HS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., O'Meara TR; Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA., McGrath ME; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA., Saito Y; Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA., Chen J; Research Computing Group, Boston Children's Hospital, Boston, MA, USA., Diray-Arce J; Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Song K; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Xu AZ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Barman S; Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Menon M; Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA., Dong D; Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA., Caradonna TM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Feldman J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Hauser BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Schmidt AG; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA., Baden LR; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Ernst RK; Department of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, MD, USA., Dillen C; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA., Yu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Chang A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Hilgers L; LiteVax B.V, Oss, The Netherlands., Platenburg PP; LiteVax B.V, Oss, The Netherlands., Dhe-Paganon S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Ozonoff A; Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT & Harvard, Cambridge, MA, USA., Zanoni I; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Division of Immunology, Boston Children's Hospital, Boston, MA, USA., Frieman MB; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA., Dowling DJ; Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Levy O; Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA. ofer.levy@childrens.harvard.edu.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. ofer.levy@childrens.harvard.edu.; Broad Institute of MIT & Harvard, Cambridge, MA, USA. ofer.levy@childrens.harvard.edu.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2023 Feb 14; Vol. 8 (1), pp. 18. Date of Electronic Publication: 2023 Feb 14.

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.

Autor: O'Meara TR; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA 02115., Nanishi E; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA 02115.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA 02115., McGrath ME; Center for Pathogen Research, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA 21201., Barman S; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA 02115.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA 02115., Dong D; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA 02115., Dillen C; Center for Pathogen Research, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA 21201., Menon M; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA 02115., Seo HS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA 02115.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA 02115., Dhe-Paganon S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA 02115.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA 02115., Ernst RK; Department of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, MD, USA 21201., Levy O; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA 02115.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA 02115.; Broad Institute of MIT & Harvard, Cambridge, MA, USA 02142., Frieman MB; Center for Pathogen Research, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA 21201., Dowling DJ; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA 02115.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA 02115.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2022 Dec 07. Date of Electronic Publication: 2022 Dec 07.