Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Nanhu Quan"'
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102602- (2023)
Externí odkaz:
https://doaj.org/article/973952da9bd44731ad39798dcbf2aa5f
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101637- (2020)
Sestrin2 (Sesn2) is a stress sensor for the mammalian target of rapamycin complex 1 (mTORC1) pathway. Aging impairs cardiac mTORC1 activation, thereby sensitizing the heart to hypertrophy. C57BL/6 J young wild-type (young WT; 4–6 months), aged WT (
Externí odkaz:
https://doaj.org/article/1d5c12fd2b874fe5a8e2282b2bf46d0c
Publikováno v:
Redox Biology, Vol 34, Iss , Pp 101556- (2020)
Ischemia heart disease is the leading cause of death world-widely and has increased prevalence and exacerbated myocardial infarction with aging. Sestrin2, a stress-inducible protein, declines with aging in the heart and the rescue of Sestrin2 in the
Externí odkaz:
https://doaj.org/article/dfabbe939d154b7481aeb34ce0bc25ea
Publikováno v:
Free Radical Biology and Medicine. 165:385-394
Sestrin2 (Sesn2) is a stress-inducible protein that plays a critical role in the response to ischemic stress. We recently recognized that Sesn2 may protect the heart against ischemic insults by reducing the generation of reactive oxygen species (ROS)
Autor:
Nanhu Quan, Peng Hui, Jiangcheng Shi, Su Xing, Jie Lu, Bai Yang, Bokang Qiao, Yang Zheng, Xiaoyu Du
Publikováno v:
International Journal of Cardiology. 302:150-156
Spontaneous coronary artery dissection (SCAD) has emerged as an important etiology of myocardial infarction and sudden death, especially in young women. Early diagnosis is essential for appropriate management.To explore the value of plasma fibrillin-
Publikováno v:
Aging and Disease
Sestrins (Sesns), including Sesn1, Sesn2, and Sesn3, are cysteine sulfinyl reductases that play critical roles in the regulation of peroxide signaling and oxidant defense. Sesn2 is thought to regulate cell growth, metabolism, and survival response to
Publikováno v:
Free radical biologymedicine. 163
Physiological reactive oxygen species (ROS) play an important role in cellular signal transduction. However, excessive ROS is an important pathological mechanism in most cardiovascular diseases (CVDs), such as myocardial aging, cardiomyopathy, ischem
Publikováno v:
Ageing research reviews. 62
As an inevitable biological process, cardiovascular aging is the greatest risk factor for cardiovascular diseases (CVDs). Sestrin 2 (Sesn2), a stress-inducible and age-related protein associated with various stress conditions, plays a pivotal role in
Autor:
Xinchun Zhou, Lin Wang, Courtney Cates, Thomas Rousselle, Nanhu Quan, Wanqing Sun, Xu Chen, Xuezhong Zhao, Ji Li
Publikováno v:
Cardiovascular Research. 114:805-821
Aims A longevity gene, Sirtuin 1 (SIRT1) and energy sensor AMP-activated protein kinase (AMPK) have common activators such as caloric restriction, oxidative stress, and exercise. The objective of this study is to characterize the role of cardiomyocyt
Autor:
Chelsea Luckett, Courtney Cates, Ji Li, Yang Zheng, Thomas Rousselle, Lin Wang, Xu Chen, Nanhu Quan
Publikováno v:
Journal of Molecular and Cellular Cardiology. 115:170-178
We have revealed that a novel stress-inducible protein, Sestrin2, declines in the heart with aging. Moreover, there is an interaction between Sestrin2 and energy sensor AMPK in the heart in response to ischemic stress. The objective of this study is