Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nanet Willumsen"'
Autor:
Mirjana Babić Leko, Ena Španić Popovački, Nanet Willumsen, Matea Nikolac Perković, Nikolina Pleić, Klara Zubčić, Lea Langer Horvat, Željka Vogrinc, Marina Boban, Fran Borovečki, Tatijana Zemunik, Rohan de Silva, Goran Šimić
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
IntroductionGenetic studies have shown that variants in the microtubule-associated protein tau (MAPT) gene, which encodes tau protein, can increase the risk for Alzheimer’s disease (AD). Additionally, two haplotypes of the MAPT gene (H1 and H2) are
Externí odkaz:
https://doaj.org/article/97c012c1878d4549bb1a5124b3f5cc7d
Autor:
Stergios Tsartsalis, Hannah Sleven, Nurun Fancy, Frank Wessely, Amy M. Smith, Nanet Willumsen, To Ka Dorcas Cheung, Michal J. Rokicki, Vicky Chau, Eseoghene Ifie, Combiz Khozoie, Olaf Ansorge, Xin Yang, Marion H. Jenkyns, Karen Davey, Aisling McGarry, Robert C. J. Muirhead, Stephanie Debette, Johanna S. Jackson, Axel Montagne, David R. Owen, J. Scott Miners, Seth Love, Caleb Webber, M. Zameel Cader, Paul M. Matthews
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Brain perfusion and blood-brain barrier (BBB) integrity are reduced early in Alzheimer’s disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from AD and non-diseased control brains to characterise pathologic
Externí odkaz:
https://doaj.org/article/6d33fcf5b51e487193ad2c53717ad721
Autor:
Charles Arber, Christopher Lovejoy, Lachlan Harris, Nanet Willumsen, Argyro Alatza, Jackie M. Casey, Georgie Lines, Caoimhe Kerins, Anika K. Mueller, Henrik Zetterberg, John Hardy, Natalie S. Ryan, Nick C. Fox, Tammaryn Lashley, Selina Wray
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108615- (2021)
Summary: Mutations in presenilin 1 (PSEN1) or presenilin 2 (PSEN2), the catalytic subunit of γ-secretase, cause familial Alzheimer’s disease (fAD). We hypothesized that mutations in PSEN1 reduce Notch signaling and alter neurogenesis. Expression d
Externí odkaz:
https://doaj.org/article/7f979cc3b908483da5f10f85ac910f06
Autor:
Nanet Willumsen, Charles Arber, Christopher Lovejoy, Jamie Toombs, Argyro Alatza, Philip S J Weston, Lucia Chávez-Gutiérrez, John Hardy, Henrik Zetterberg, Nick C Fox, Natalie S Ryan, Tammaryn Lashley, Selina Wray
Publikováno v:
Brain Communications. 5
Mutations in the presenilin 1 gene, PSEN1, which cause familial Alzheimer's disease alter the processing of amyloid precursor protein, leading to the generation of various amyloid-β peptide species. These species differ in their potential for aggreg
Autor:
Amanda Heslegrave, Lucía Chávez-Gutiérrez, Josef Pannee, Helen Rice, Imogen Swift, Antoinette O'Connor, Jennifer M. Nicholas, Emily Abel, Nanet Willumsen, Henrik Zetterberg, Simon Mead, Selina Wray, Nick C. Fox, Charles Arber, Chris Frost, James M. Polke, Erik Portelius, Kaj Blennow, Philip S.J. Weston, Teresa Poole, Natalie S. Ryan
Publikováno v:
Brain
In vitro studies of autosomal dominant Alzheimer’s disease implicate longer amyloid-β peptides in disease pathogenesis; however, less is known about the behaviour of these mutations in vivo. In this cross-sectional cohort study, we used liquid chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb18fa743001979676e88b0dddc7cfea
https://lirias.kuleuven.be/handle/123456789/679509
https://lirias.kuleuven.be/handle/123456789/679509
Autor:
Tammaryn Lashley, Nick C. Fox, Teresa Poole, Natalie S. Ryan, Nanet Willumsen, Jennifer M. Nicholas
Publikováno v:
Brain pathology (Zurich, Switzerland). 32(3)
Familial Alzheimer's disease (FAD) is caused by autosomal dominant mutations in the PSEN1, PSEN2 or APP genes, giving rise to considerable clinical and pathological heterogeneity in FAD. Here we investigate variability in clinical data and the type a
Autor:
Erik Portelius, Lucía Chávez-Gutiérrez, Imogen Swift, Emily Abel, Kaj Blennow, Antoinette O'Connor, Chris Frost, Nanet Willumsen, Charles Arber, Philip Sj. Weston, James M. Polke, Teresa Poole, Natalie S. Ryan, Amanda Heslegrave, Nick C. Fox, Jennifer M. Nicholas, Josef Pannee, Helen Rice, Henrik Zetterberg, Simon Mead, Selina Wray
In-vitrostudies of autosomal dominant Alzheimer’s disease (ADAD) implicate longer Aβ peptides in pathogenesis, however less is known about the behaviour of ADAD mutationsin-vivo. In this cross-sectional cohort study, we used liquid chromatography-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b65cf204bd36381598030a36d6a06bf
https://doi.org/10.1101/2021.02.11.430756
https://doi.org/10.1101/2021.02.11.430756
Autor:
Argyro Alatza, Jackie M. Casey, John Hardy, Lachlan Harris, Caoimhe Kerins, Nick C. Fox, Henrik Zetterberg, Tammaryn Lashley, Selina Wray, Nanet Willumsen, Georgie Lines, Charles Arber, Natalie S. Ryan, Anika K. Mueller, Christopher Lovejoy
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108615-(2021)
Cell Reports
Cell Reports
Summary Mutations in presenilin 1 (PSEN1) or presenilin 2 (PSEN2), the catalytic subunit of γ-secretase, cause familial Alzheimer’s disease (fAD). We hypothesized that mutations in PSEN1 reduce Notch signaling and alter neurogenesis. Expression da
Autor:
Nick C. Fox, Georgie Lines, Tammaryn Lashley, Charles Arber, Nanet Willumsen, Jackie M. Casey, Christopher E.J. Lovejoy, Henrik Zetterberg, Natalie S. Ryan, Selina Wray, John Hardy, Argyro Alatza, Caoimhe Kerins
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
John Hardy, Nick C. Fox, Kaj Blennow, Henrik Zetterberg, Nanet Willumsen, Selina Wray, Charles Arber, Erik Portelius, Amanda Heslegrave, Eleni Gkanatsiou, Jonathan M. Schott, Ross W. Paterson, Jamie Toombs, Natalie S. Ryan, Tammaryn Lashley, Christopher E.J. Lovejoy
Publikováno v:
Alzheimer's & Dementia. 15