Common variant at 16p11.2 conferring risk of psychosis

Autor: Steinberg, Stacy, de Jong, S, Mattheisen, M, Costas, J, Demontis, D, Jamain, S, Pietilainen, OPH, Lin, K, Papiol, S, Huttenlocher, J, Sigurdsson, E, Vassos, E, Giegling, I, Breuer, R, Fraser, G, Walker, N, Melle, Ingrid, Djurovic, Srdjan, Agartz, Ingrid, Tuulio-Henriksson, A, Suvisaari, J, Lonnqvist, J, Paunio, T, Olsen, L, Hansen, T, Ingason, A, Pirinen, M, Strengman, E, Hougaard, DM, Orntoft, T, Didriksen, M, Hollegaard, MV, Nordentoft, M, Abramova, L, Kaleda, V, Arrojo, M, Sanjuan, J, Arango, C, Etain, B, Bellivier, F, Meary, A, Schurhoff, F, Szoke, A, Ribolsi, M, Magni, V, Siracusano, A, Sperling, S, Rossner, M, Christiansen, C, Kiemeney, LA, Franke, B, van den Berg, LH, Veldink, J, Curran, S, Bolton, P, Poot, M, Staal, W, Rehnstrom, K, Kilpinen, H, Freitag, CM, Meyer, J, Magnusson, P, Saemundsen, E, Martsenkovsky, I, Bikshaieva, I, Martsenkovska, I, Vashchenko, O, Raleva, M, Paketchieva, K, Stefanovski, B, Durmishi, N, Milovancevic, MP, Tosevski, DL, Silagadze, T, Naneishvili, N, Mikeladze, N, Surguladze, S, Vincent, JB, Farmer, A, Mitchell, PB, Wright, A, Schofield, PR, Fullerton, JM, Montgomery, GW, Martin, NG, Rubino, IA, van Winkel, R, Kenis, G, De Hert, M, Rethelyi, JM, Bitter, I, Terenius, L, Jonsson, EG, Bakker, S, van Os, J, Jablensky, A, Leboyer, M, Bramon, E, Powell, J, Murray, R, Corvin, A, Gill, M, Morris, D, O'Neill, FA, Kendler, K, Riley, B, Craddock, N, Owen, MJ, O'Donovan, MC, Thorsteinsdottir, U, Kong, A, Ehrenreich, H, Carracedo, A, Golimbet, V, Andreassen, Ole Andreas, Borglum, AD, Mors, O, Mortensen, PB, Werge, T, Ophoff, RA, Nothen, MM, Rietschel, M, Cichon, S, Ruggeri, M, Tosato, S, Palotie, A, St Clair, D, Rujescu, D, Collier, DA, Stefansson, H, Stefánsson, Kári

Publikováno v: Steinberg, Stacy de Jong, S Mattheisen, M Costas, J Demontis, D Jamain, S Pietilainen, OPH Lin, K Papiol, S Huttenlocher, J Sigurdsson, E Vassos, E Giegling, I Breuer, R Fraser, G Walker, N Melle, Ingrid Djurovic, Srdjan Agartz, Ingrid Tuulio-Henriksson, A Suvisaari, J Lonnqvist, J Paunio, T Olsen, L Hansen, T Ingason, A Pirinen, M Strengman, E Hougaard, DM Orntoft, T Didriksen, M Hollegaard, MV Nordentoft, M Abramova, L Kaleda, V Arrojo, M Sanjuan, J Arango, C Etain, B Bellivier, F Meary, A Schurhoff, F Szoke, A Ribolsi, M Magni, V Siracusano, A Sperling, S Rossner, M Christiansen, C Kiemeney, LA Franke, B van den Berg, LH Veldink, J Curran, S Bolton, P Poot, M Staal, W Rehnstrom, K Kilpinen, H Freitag, CM Meyer, J Magnusson, P Saemundsen, E Martsenkovsky, I Bikshaieva, I Martsenkovska, I Vashchenko, O Raleva, M Paketchieva, K Stefanovski, B Durmishi, N Milovancevic, MP Tosevski, DL Silagadze, T Naneishvili, N Mikeladze, N Surguladze, S Vincent, JB Farmer, A Mitchell, PB Wright, A Schofield, PR Fullerton, JM Montgomery, GW Martin, NG Rubino, IA van Winkel, R Kenis, G De Hert, M Rethelyi, JM Bitter, I Terenius, L Jonsson, EG Bakker, S van Os, J Jablensky, A Leboyer, M Bramon, E Powell, J Murray, R Corvin, A Gill, M Morris, D O'Neill, FA Kendler, K Riley, B Craddock, N Owen, MJ O'Donovan, MC Thorsteinsdottir, U Kong, A Ehrenreich, H Carracedo, A Golimbet, V Andreassen, Ole Andreas Borglum, AD Mors, O Mortensen, PB Werge, T Ophoff, RA Nothen, MM Rietschel, M Cichon, S Ruggeri, M Tosato, S Palotie, A St Clair, D Rujescu, D Collier, DA Stefansson, H Stefánsson, Kári . Common variant at 16p11.2 conferring risk of psychosis. Molecular Psychiatry. 2014, 19, 108-114
Molecular Psychiatry

Externí odkaz: http://hdl.handle.net/10852/43572
https://www.duo.uio.no/bitstream/handle/10852/43572/2/Common%2Bvariant%2Bat%2B16p11.2%2Bconferring%2Brisk%2Bof%2Bpsychosis.pdf

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Common variant at 16p11.2 conferring risk of psychosis.

Autor: Steinberg S; deCODE genetics, Reykjavik, Iceland., de Jong S; Center for Neurobehavioral Genetics, UCLA, Los Angeles, CA, USA., Mattheisen M; 1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Institute for Genomic Mathematics, University of Bonn, Bonn, Germany [3] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany., Costas J; Galician Foundation of Genomic Medicine-SERGAS, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain., Demontis D; 1] Department of Biomedicine, Human Genetics, and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark [2] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark., Jamain S; 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France., Pietiläinen OP; 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland [3] Wellcome Trust Sanger Institute, Cambridge, UK., Lin K; Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK., Papiol S; 1] DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany [2] Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany., Huttenlocher J; 1] deCODE genetics, Reykjavik, Iceland [2] Department of Medical Genetics, Institute of Human Genetics, University of Tübingen, Tübingen, Germany., Sigurdsson E; 1] Department of Psychiatry, National University Hospital, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland., Vassos E; Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK., Giegling I; Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany., Breuer R; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany., Fraser G; Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK., Walker N; Ravenscraig Hospital, Greenock, UK., Melle I; Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway., Djurovic S; Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway., Agartz I; Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway., Tuulio-Henriksson A; Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Suvisaari J; Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Lönnqvist J; Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Paunio T; Public Health Genomics Unit, National Institute for Health and Welfare THL, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Olsen L; Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark., Hansen T; Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark., Ingason A; Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark., Pirinen M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Strengman E; Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands., Hougaard DM; Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark., Orntoft T; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Didriksen M; Synaptic transmission, H. Lundbeck A/S, Copenhagen, Denmark., Hollegaard MV; Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark., Nordentoft M; 1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] Psychiatric Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Abramova L; Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia., Kaleda V; Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia., Arrojo M; Service of Psychiatry, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain., Sanjuán J; Unit of Psychiatry, Faculty of Medicine, University of Valencia, Network Center of Biomedical Research on Mental Health (CIBERSAM), Valencia, Spain., Arango C; Hospital General Universitario Gregorio Marañón, IiSGM, Universidad Complutense, CIBERSAM, Madrid, Spain., Etain B; 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France., Bellivier F; 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France., Méary A; 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France., Schürhoff F; 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France., Szoke A; 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France., Ribolsi M; Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy., Magni V; Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy., Siracusano A; Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy., Sperling S; Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany., Rossner M; 1] DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany [2] Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany., Christiansen C; Nordic Bioscience, Herlev, Denmark., Kiemeney LA; Department of Epidemiology and Biostatistics and Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands., Franke B; Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands., van den Berg LH; Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands., Veldink J; Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands., Curran S; 1] Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK [2] Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College, London UK., Bolton P; 1] Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK [2] Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College, London UK., Poot M; Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands., Staal W; Department of Cognitive Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands., Rehnstrom K; 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Wellcome Trust Sanger Institute, Cambridge, UK., Kilpinen H; 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Wellcome Trust Sanger Institute, Cambridge, UK., Freitag CM; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Frankfurt am Main, Frankfurt am Main, Germany., Meyer J; Department of Neurobehavioural Genetics, University of Trier, Trier, Germany., Magnusson P; Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, Iceland., Saemundsen E; State Diagnostic and Counseling Centre, Kopavogur, Iceland., Martsenkovsky I; Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine., Bikshaieva I; Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine., Martsenkovska I; Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine., Vashchenko O; Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine., Raleva M; Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia., Paketchieva K; Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia., Stefanovski B; Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia., Durmishi N; Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia., Pejovic Milovancevic M; 1] Institute of Mental Health, Belgrade, Serbia [2] Medical Faculty, University of Belgrade, Belgrade, Serbia., Lecic Tosevski D; 1] Institute of Mental Health, Belgrade, Serbia [2] Medical Faculty, University of Belgrade, Belgrade, Serbia., Silagadze T; Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia., Naneishvili N; Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia., Mikeladze N; Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia., Surguladze S; Social and Affective Neuroscience Lab, Ilia State University, Tbilisi, Georgia., Vincent JB; Molecular Neuropsychiatry and Development Laboratory, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Farmer A; Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK., Mitchell PB; 1] Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia [2] School of Psychiatry, University of New South Wales, Sydney, NSW, Australia., Wright A; 1] Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia [2] School of Psychiatry, University of New South Wales, Sydney, NSW, Australia., Schofield PR; 1] Neuroscience Research Australia, Barker Street, Sydney, NSW, Australia [2] School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia., Fullerton JM; 1] Neuroscience Research Australia, Barker Street, Sydney, NSW, Australia [2] School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia., Montgomery GW; Queensland Institute of Medical Research, Brisbane, QLD, Australia., Martin NG; Queensland Institute of Medical Research, Brisbane, QLD, Australia., Rubino IA; Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy., van Winkel R; 1] University Psychiatric Center, Catholic University Leuven, Kortenberg, Belgium [2] Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Center, Maastricht, The Netherlands., Kenis G; Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Center, Maastricht, The Netherlands., De Hert M; University Psychiatric Center, Catholic University Leuven, Kortenberg, Belgium., Réthelyi JM; Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary., Bitter I; Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary., Terenius L; Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden., Jönsson EG; Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden., Bakker S; Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands., van Os J; Department of Psychiatry, Maastricht University Medical Centre, Maastricht, The Netherlands., Jablensky A; Centre for Clinical Research in Neuropsychiatry (CCRN), Graylands Hospital, the University of Western Australia, Perth, WA, Australia., Leboyer M; 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. 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Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France., Bramon E; Mental Health Sciences Unit and Institute of Cognitive Neuroscience, University College London, London, UK., Powell J; Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK., Murray R; Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK., Corvin A; Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland., Gill M; Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland., Morris D; Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland., O'Neill FA; Department of Psychiatry, Queens University, Belfast, UK., Kendler K; 1] Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA [2] Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA [3] Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Riley B; 1] Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA [2] Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA [3] Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Craddock N; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK., Owen MJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK., O'Donovan MC; MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK., Thorsteinsdottir U; 1] deCODE genetics, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland., Kong A; deCODE genetics, Reykjavik, Iceland., Ehrenreich H; 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1] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany [2] Institute of Human Genetics, University of Bonn, Bonn Germany [3] Institute of Neurosciences and Medicine (INM-1), Juelich, Germany., Ruggeri M; Section of Psychiatry, University of Verona, Verona, Italy., Tosato S; Section of Psychiatry, University of Verona, Verona, Italy., Palotie A; 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Wellcome Trust Sanger Institute, Cambridge, UK [3] Program in Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA [4] Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland., St Clair D; Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK., Rujescu D; 1] Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany [2] Department of Psychiatry, University of Halle-Wittenberg, Halle, Germany., Collier DA; 1] Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK [2] Eli Lilly and Co. Ltd, Erl Wood Manor, Windlesham, Surrey, UK., Stefansson H; deCODE genetics, Reykjavik, Iceland., Stefansson K; 1] deCODE genetics, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2014 Jan; Vol. 19 (1), pp. 108-14. Date of Electronic Publication: 2012 Nov 20.