Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nandy Hofland"'
Autor:
Anne-Sophie van der Werf't Lam, Noah C. Helderman, Arnoud Boot, Diantha Terlouw, Hans Morreau, Hailian Mei, Rebecca E.E. Esveldt-van Lange, Inge M.M. Lakeman, Christi J. van Asperen, Emmelien Aten, Nandy Hofland, Pia A.M. de Koning Gans, Emily Rayner, Carli Tops, Niels de Wind, Tom van Wezel, Maartje Nielsen
Publikováno v:
Experimental and Molecular Pathology, Vol 140, Iss , Pp 104940- (2024)
Functional analyses are the main method to classify mismatch repair (MMR) gene variants of uncertain significance (VUSs). However, the pathogenicity remains unclear for many variants because of conflicting results between clinical, molecular, and fun
Externí odkaz:
https://doaj.org/article/495ee08f0dc6450c81f1b9f564d08794
Autor:
Kimberley de Koning, Anne J. Roukema, Magdalena van Heck, Corinne van der Kaa, Frederik J. Hes, Roeland A. Veenendaal, Wouter H. de Vos tot Nederveen Cappel, Juul T. Wijnen, James C. H. Hardwick, Nandy Hofland, Maartje Nielsen, Daan W. Hommes, Aad Tibben, Carli M. J. Tops, Christi J. van Asperen, Hans Morreau, Katja N. Gaarenstroom, Rob A. E. M. Tollenaar, Alexandra M. J. Langers, Jessica P. Gopie, Hans F. A. Vasen, Simone D. Hennink
Publikováno v:
Familial Cancer, 12(2), 347-354. Springer
Familial Cancer, 12(2), 347-354
Familial Cancer, 12(2), 347-354. Springer Netherlands
Familial Cancer, 12(2), 347-354
Familial Cancer, 12(2), 347-354. Springer Netherlands
Lynch syndrome (LS), one of the most frequent forms of hereditary colorectal cancer (CRC), is caused by a defect in one of the mismatch repair (MMR) genes. Carriers of MMR defects have a strongly increased risk of developing CRC and endometrial cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b940d94263db742661479cc5bd66a7
https://doi.org/10.1007/s10689-013-9655-6
https://doi.org/10.1007/s10689-013-9655-6
Publikováno v:
British Journal of Cancer
Scopus-Elsevier
Scopus-Elsevier
The role of Msh2 in chromosome stability has been investigated in a targeted mouse model for HNPCC, Msh2Delta7N. Chromosome aberration frequencies were similar in bone marrow of Msh2(+/+), Msh2(+/-)and Msh2(-/-)mice and no differential effects of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d0cc5b2fa9b3c0e998fb174fa760f5
https://doi.org/10.1054/bjoc.2000.1422
https://doi.org/10.1054/bjoc.2000.1422
Autor:
Riccardo Fodde, Raju Kucherlapati, Kristi L. Neufeld, P. Meera Khan, Ron Smits, Ray White, Cor Breukel, Winfried Edelmann, Menno F. Kielman, Nandy Hofland, Shantie Jagmohan-Changur, Jaap E. van Dijk, Chris Zurcher
Publikováno v:
Scopus-Elsevier
Genes and Development, 13(10), 1309-1321. Cold Spring Harbor Laboratory Press
Genes and Development, 13(10), 1309-1321. Cold Spring Harbor Laboratory Press
The adenomatous polyposis coli (APC) gene is considered as the true gatekeeper of colonic epithelial proliferation: It is mutated in the majority of colorectal tumors, and mutations occur at early stages of tumor development in mouse and man. These m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca28a67115e2c1543131590bc9a6f5e0
https://doi.org/10.1101/gad.13.10.1309
https://doi.org/10.1101/gad.13.10.1309
Publikováno v:
Scopus-Elsevier
Colorectal cancer still represents one of the most common causes of morbidity and mortality among Western populations. The adenomatous polyposis coli (APC) gene, originally identified as the gene responsible for familial adenomatous polyposis (FAP),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c320a53a3e5a98f2909a185c67b426c6
https://doi.org/10.1159/000015361
https://doi.org/10.1159/000015361
Autor:
Christi J. van Asperen, Frans B. L. Hogervorst, Maaike P.G. Vreeswijk, Setareh Moghadasi, Nandy Hofland, Joyce N Wouts, Juul T. Wijnen
Publikováno v:
Journal of Medical Genetics, 50(2), 74-9
BACKGROUND Nearly 15% of BRCA1 and BRCA2 DNA tests lead to the identification of Variants of Uncertain Significance (VUS). VUS are classified in the Netherlands according to the Bell system and it is current practice that class III VUS are communicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0a7e9a19632f5f2bb4ee0f8f4b74b1
https://hdl.handle.net/1887/97031
https://hdl.handle.net/1887/97031
Autor:
Marjan Geugien, Raju Kucherlapati, Riccardo Fodde, Nandy Hofland, Cristina Albuquerque, Winfried Edelmann, Cor Breukel, Shantie Jagmohan-Changur, Ron Smits, Menno F. Kielman
Publikováno v:
Genes Chromosomes and Cancer, 29(3), 229-239. Wiley-Liss Inc.
The APC gene, originally identified as the gene for familial adenomatous polyposis (FAP), is now considered as the true "gatekeeper" of colonic epithelial proliferation. Its main tumor suppressing activity seems to reside in the capacity to properly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23b5c05c9e4d4ff12fefe9f1a92771d
https://pure.eur.nl/en/publications/d804d090-75a1-4899-bc8c-30707a3d98cb
https://pure.eur.nl/en/publications/d804d090-75a1-4899-bc8c-30707a3d98cb
Publikováno v:
Nucleic acids research. 22(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46a0428a7751cc0446e6ef466f86532
https://pubmed.ncbi.nlm.nih.gov/8202385
https://pubmed.ncbi.nlm.nih.gov/8202385