Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Nandor Garamszegi"'
Autor:
Muhammad Umar Jawad, Nandor Garamszegi, Susanna P Garamszegi, Mayrin Correa-Medina, Juan A Diez, Rong Wen, Sean P Scully
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14250 (2010)
In carcinomas stromal cells participate in cancer progression by producing proteases such as MMPs. The expression MMP1 is a prognostic factor in human chondrosarcoma, however the role in tumor progression is unknown. Laser capture microdissection and
Externí odkaz:
https://doaj.org/article/1e44749e17a043b793865eff43ec57ff
Extracellular matrix (ECM) molecules modify gene expression through attachment-dependent (focal adhesion-related) integrin receptor signaling. It was previously unknown whether the same molecules acting as soluble peptides could generate signal casca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f5da1fe92608ce8f63dc719345b5bd
https://doi.org/10.1158/1541-7786.c.6542241.v1
https://doi.org/10.1158/1541-7786.c.6542241.v1
Publikováno v:
Current Molecular Pharmacology. 5:327-339
Tumorigenesis is regulated by the complex cell-matrix signalling interactions that incorporate feedback mechanisms from constantly evolving microenvironments. Under normal circumstances, these matrix signalling processes together with infiltrating im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dedd58ea6a55da6535c0d20a177b9f41
https://doi.org/10.2174/1874467211205030002
https://doi.org/10.2174/1874467211205030002
Publikováno v:
Journal of Cellular and Molecular Medicine
Matrix metalloproteinase-1 (MMP-1) activity has been linked to numerous disease processes from arthritis to ulcer. Its proteolytic activity has been implicated inconsistently in different steps of tumourigenesis and metastasis. The discrepancies may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4622254d4562383a70ee9705498fcd30
https://doi.org/10.1111/j.1582-4934.2011.01402.x
https://doi.org/10.1111/j.1582-4934.2011.01402.x
Autor:
E Walford, Payman Samavarchi-Tehrani, Jeffery L. Wrana, Sean P. Scully, Susanna P. Garamszegi, Nandor Garamszegi, M M Schneiderbauer
Publikováno v:
Oncogene. 29:2368-2380
Matrix remodeling, degradation, inflammation and invasion liberate peptide fragments that can subsequently interact with cells in an attachment-independent manner. Such 'soluble' matrix components, including collagens, fibronectin and laminin, induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09e1a44e3f21cdba61ad5eacf9ed47b
https://doi.org/10.1038/onc.2009.514
https://doi.org/10.1038/onc.2009.514
Autor:
Nandor Garamszegi, Emeline Maillet, Deborah C. Mash, Nicolas Milon, James A. Fishback, Mari D. Heghinian, Stephan C. Schürer
Publikováno v:
The FASEB Journal. 29
Noribogaine is the primary metabolite of the anti-addictive substance ibogaine, which modulates opiate analgesic activity and the components of drug addiction in animal models at brain concentrations of 0.5-15 µM. In this study, molecular activities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4041492d7e48ba23b7c8e0a49f6fcc21
https://doi.org/10.1096/fasebj.29.1_supplement.lb505
https://doi.org/10.1096/fasebj.29.1_supplement.lb505
Autor:
Nandor Garamszegi, Deborah C. Mash, Nicolas Milon, Chang Qing, Emeline Maillet, Mari D. Heghinian, Taleen Hanania
Publikováno v:
The FASEB Journal. 29
Noribogaine, a polypharmacological drug with activities at opioid receptors, ionotropic nicotinic receptors, and serotonin reuptake transporters, is being investigated for treatment of substance ab...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa884a424b2c995d259d2ca43c39cc00
https://doi.org/10.1096/fasebj.29.1_supplement.1019.2
https://doi.org/10.1096/fasebj.29.1_supplement.1019.2
Autor:
Yi-Chin Fong, Franklin H. Sim, Stephen S. Cha, Sean P. Scully, Charyl M. Dutton, Nandor Garamszegi
Publikováno v:
Clinical Cancer Research. 10:7329-7334
Purpose: Increased levels of matrix metalloproteinase 1 (MMP-1) expression have been associated with poor outcome in chondrosarcoma. The existence of a single nucleotide polymorphism creating an Ets-binding site in the MMP-1 promoter may be one mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e350a1702d24f759a0c5915430a517
https://doi.org/10.1158/1078-0432.ccr-04-0900
https://doi.org/10.1158/1078-0432.ccr-04-0900
Autor:
Charyl M. Dutton, Xiaoling Jiang, Wen-ning Qi, Sean P. Scully, Nandor Garamszegi, Joel A. Block
Publikováno v:
Journal of Cellular Physiology. 202:723-730
Matrix metalloproteinases (MMPs) play a crucial role in tumor cell invasion and metastasis. Expression of MMP-1 has been reported as a prognostic predictor of recurrence in human chondrosarcoma, and studies using human chondrosarcoma cell lines indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd002ebfdb92dda8db4f9b8868e8936
https://doi.org/10.1002/jcp.20162
https://doi.org/10.1002/jcp.20162
Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3
Publikováno v:
Molecular and Cellular Biology. 23:8878-8889
Transforming growth factor beta (TGF-beta) causes growth arrest in epithelial cells and proliferation and morphological transformation in fibroblasts. Despite the ability of TGF-beta to induce various cellular phenotypes, few discernible differences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15dae4a85cc49b08a89c0f78890b2572
https://doi.org/10.1128/mcb.23.23.8878-8889.2003
https://doi.org/10.1128/mcb.23.23.8878-8889.2003