BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections.

Autor: Hameed P S; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Kotakonda H; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Sharma S; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Nandishaiah R; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Katagihallimath N; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Rao R; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Sadler C; Apconix Ltd. Alderley Park, Alderley Edge, Cheshire, SK10 4TG, UK., Slater I; Apconix Ltd. Alderley Park, Alderley Edge, Cheshire, SK10 4TG, UK., Morton M; Apconix Ltd. Alderley Park, Alderley Edge, Cheshire, SK10 4TG, UK., Chandrasekaran A; RxMD, 320/1, Lloyds Road, Royapettah, Chennai, 600 014, India., Griffen E; Medchemica Ltd., No. 8162245, Ebenezer House, Newcastle-under-Lyme, Staffordshire, ST5 2BE, England., Pillai D; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Reddy S; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Bharatham N; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Venkatesan S; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Jonnalagadda V; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Jayaraman R; TheraIndx Lifesciences Pvt. Ltd., Sy No. 27, Deganahalli, Bangalore, 562123, India., Nanjundappa M; TheraIndx Lifesciences Pvt. Ltd., Sy No. 27, Deganahalli, Bangalore, 562123, India., Sharma M; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Raveendran S; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Rajagopal S; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Tumma H; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Watters A; JMI Laboratories, 345 Beaver Kreek Center, North Liberty, IA, 52317, USA., Becker H; JMI Laboratories, 345 Beaver Kreek Center, North Liberty, IA, 52317, USA., Lindley J; JMI Laboratories, 345 Beaver Kreek Center, North Liberty, IA, 52317, USA., Flamm R; JMI Laboratories, 345 Beaver Kreek Center, North Liberty, IA, 52317, USA., Huband M; JMI Laboratories, 345 Beaver Kreek Center, North Liberty, IA, 52317, USA., Sahm D; IHMA USA, 2122 Palmer Drive, Schaumburg, IL, 60173-3817, USA., Hackel M; IHMA USA, 2122 Palmer Drive, Schaumburg, IL, 60173-3817, USA., Mathur T; IHMA India, Gurugram, Haryana, 122018, India., Kolamunnage-Dona R; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7BE, UK., Unsworth J; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7BE, UK., Mcentee L; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7BE, UK., Farrington N; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7BE, UK., Manickam D; Syngene International Ltd., Biocon Park, Plot No. 2 & 3, Bommasandra Jigani Link Road, Bangalore, 560 099, India., Chandrashekara N; Syngene International Ltd., Biocon Park, Plot No. 2 & 3, Bommasandra Jigani Link Road, Bangalore, 560 099, India., Jayachandiran S; Syngene International Ltd., Biocon Park, Plot No. 2 & 3, Bommasandra Jigani Link Road, Bangalore, 560 099, India., Reddy H; Syngene International Ltd., Biocon Park, Plot No. 2 & 3, Bommasandra Jigani Link Road, Bangalore, 560 099, India., Shanker S; Syngene International Ltd., Biocon Park, Plot No. 2 & 3, Bommasandra Jigani Link Road, Bangalore, 560 099, India., Richard V; Narayana Health, Mazumdar Shaw Medical Center, 258/A, Bommasandra Industrial Area, Hosur Road, Bangalore, 560 099, India., Thomas T; Microbiology laboratory, St. John's Hospital, Sarjapur Road, Bangalore, 560 034, India., Nagaraj S; Microbiology laboratory, St. John's Hospital, Sarjapur Road, Bangalore, 560 034, India., Datta S; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Sambandamurthy V; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Ramachandran V; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Clay R; Highbury Regulatory Science Limited, SK10 4TG, Nether Alderley, Cheshire, SK10 4TG, UK., Tomayko J; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India., Das S; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 7BE, UK., V B; Bugworks Research India Pvt. Ltd. Center for Cellular & Molecular Platforms, National Center for Biological Sciences, GKVK Campus, Bellary Road, Bangalore, 560 065, India. bala@bugworksresearch.com.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 18; Vol. 15 (1), pp. 8202. Date of Electronic Publication: 2024 Sep 18.

Nitrothiophene carboxamides, a novel narrow spectrum antibacterial series: Mechanism of action and Efficacy.

Autor: Hameed P S; BUGWORKS Research India Pvt. Ltd., Centre for Cellular & Molecular Platforms, National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India., Bharatham N; Centre for Cellular and Molecular Platforms (C-CAMP), National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India., Katagihallimath N; BUGWORKS Research India Pvt. Ltd., Centre for Cellular & Molecular Platforms, National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India., Sharma S; BUGWORKS Research India Pvt. Ltd., Centre for Cellular & Molecular Platforms, National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India., Nandishaiah R; BUGWORKS Research India Pvt. Ltd., Centre for Cellular & Molecular Platforms, National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India., Shanbhag AP; BUGWORKS Research India Pvt. Ltd., Centre for Cellular & Molecular Platforms, National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India., Thomas T; St. John's Research Institute, 100 Feet Rd, John Nagar, Koramangala, Bengaluru, Karnataka, 560034, India., Narjari R; BUGWORKS Research India Pvt. Ltd., Centre for Cellular & Molecular Platforms, National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India., Sarma M; BUGWORKS Research India Pvt. Ltd., Centre for Cellular & Molecular Platforms, National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India., Bhowmik P; BUGWORKS Research India Pvt. Ltd., Centre for Cellular & Molecular Platforms, National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India., Amar P; BUGWORKS Research India Pvt. Ltd., Centre for Cellular & Molecular Platforms, National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India., Ravishankar R; BUGWORKS Research India Pvt. Ltd., Centre for Cellular & Molecular Platforms, National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India., Jayaraman R; TheraIndx Lifesciences Pvt. Ltd., Sy No. 27, Deganahalli, Budihal Post, Nelamangala, Karnataka, 562123, India., Muthan K; Syngene International Ltd., Plot 2 & 3, Bommasandra Industrial Estate - Phase-IV, Bommasandra-Jigani Link Road, Bengaluru, Karnataka, 560099, India., Subbiah R; Syngene International Ltd., Plot 2 & 3, Bommasandra Industrial Estate - Phase-IV, Bommasandra-Jigani Link Road, Bengaluru, Karnataka, 560099, India., Ramachandran V; BUGWORKS Research India Pvt. Ltd., Centre for Cellular & Molecular Platforms, National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India., Balasubramanian V; BUGWORKS Research India Pvt. Ltd., Centre for Cellular & Molecular Platforms, National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India., Datta S; BUGWORKS Research India Pvt. Ltd., Centre for Cellular & Molecular Platforms, National Centre for Biological Sciences, GKVK, Bellary Rd, Bengaluru, Karnataka, 560065, India. santanu@bugworksresearch.com.

Publikováno v: Scientific reports [Sci Rep] 2018 May 08; Vol. 8 (1), pp. 7263. Date of Electronic Publication: 2018 May 08.

Genetic and chemical validation identifies Mycobacterium tuberculosis topoisomerase I as an attractive anti-tubercular target.

Autor: Ravishankar S; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India. Electronic address: mailsuravi01@gmail.com., Ambady A; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Awasthy D; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Mudugal NV; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Menasinakai S; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Jatheendranath S; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Guptha S; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Sharma S; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Balakrishnan G; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Nandishaiah R; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Ramachandran V; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Eyermann CJ; AstraZeneca Infection, Innovative Medicines, 35 Gatehouse Drive, Waltham, MA 02451, United States., Reck F; AstraZeneca Infection, Innovative Medicines, 35 Gatehouse Drive, Waltham, MA 02451, United States., Rudrapatna S; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Sambandamurthy VK; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Sharma UK; AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.

Publikováno v: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2015 Sep; Vol. 95 (5), pp. 589-98. Date of Electronic Publication: 2015 May 27.

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate.

Autor: Hameed P S; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Solapure S; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Patil V; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Henrich PP; Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA., Magistrado PA; Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA., Bharath S; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Murugan K; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Viswanath P; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Puttur J; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Srivastava A; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Bellale E; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Panduga V; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Shanbag G; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Awasthy D; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Landge S; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Morayya S; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Koushik K; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Saralaya R; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Raichurkar A; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Rautela N; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Roy Choudhury N; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Ambady A; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Nandishaiah R; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Reddy J; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Prabhakar KR; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Menasinakai S; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Rudrapatna S; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Chatterji M; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Jiménez-Díaz MB; Tres Cantos Medicines Development Campus. Diseases of Developing World (DDW), GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Martínez MS; Tres Cantos Medicines Development Campus. Diseases of Developing World (DDW), GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Sanz LM; Tres Cantos Medicines Development Campus. Diseases of Developing World (DDW), GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Coburn-Flynn O; Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA., Fidock DA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA., Lukens AK; Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA., Wirth DF; Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA., Bandodkar B; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Mukherjee K; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., McLaughlin RE; AstraZeneca Infection Innovative Medicines, 35 Gatehouse Drive, Waltham, Massachusetts 02451, USA., Waterson D; Medicines for Malaria Venture, International Center Cointrin, Geneva 1215, Switzerland., Rosenbrier-Ribeiro L; AstraZeneca, Alderley Park, Cheshire SK10 4TF, UK., Hickling K; AstraZeneca, Alderley Park, Cheshire SK10 4TF, UK., Balasubramanian V; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Warner P; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Hosagrahara V; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Dudley A; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Iyer PS; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Narayanan S; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India., Kavanagh S; AstraZeneca, Alderley Park, Cheshire SK10 4TF, UK., Sambandamurthy VK; Department of Innovative Medicines, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India.

Publikováno v: Nature communications [Nat Commun] 2015 Mar 31; Vol. 6, pp. 6715. Date of Electronic Publication: 2015 Mar 31.

Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against Mycobacterium tuberculosis.

Autor: Hameed P S; Department of Medicinal Chemistry; ‡Department of Biosciences and §DMPK and Animal Sciences, AstraZeneca India Pvt. Ltd. , Bellary Road, Hebbal, Bangalore 560024, India., Patil V, Solapure S, Sharma U, Madhavapeddi P, Raichurkar A, Chinnapattu M, Manjrekar P, Shanbhag G, Puttur J, Shinde V, Menasinakai S, Rudrapatana S, Achar V, Awasthy D, Nandishaiah R, Humnabadkar V, Ghosh A, Narayan C, Ramya VK, Kaur P, Sharma S, Werngren J, Hoffner S, Panduga V, Kumar CN, Reddy J, Kumar K N M, Ganguly S, Bharath S, Bheemarao U, Mukherjee K, Arora U, Gaonkar S, Coulson M, Waterson D, Sambandamurthy VK, de Sousa SM

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2014 Jun 12; Vol. 57 (11), pp. 4889-905. Date of Electronic Publication: 2014 May 23.