Výsledky vyhledávání - "Nandini Sakurikar"

Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition

Autor: Alan Eastman, Jennifer P. Ditano, Nandini Sakurikar

Publikováno v: Cell Cycle

Cyclin-dependent kinase (CDK) 1 complexed with cyclin B is a driver of mitosis, while CDK2 drives S phase entry and replicon initiation. CDK2 activity increases as cells progress through S phase, and its cyclin partner switches from cyclin E to cycli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdbfaf761b7d98419a6cf6a2e1a996c
https://pubmed.ncbi.nlm.nih.gov/34156324

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Critical reanalysis of the methods that discriminate the activity of CDK2 from CDK1

Autor: Nandini Sakurikar, Alan Eastman

Publikováno v: Cell Cycle. 15:1184-1188

Cyclin dependent kinases 1 and 2 (CDK1 and CDK2) play crucial roles in regulating cell cycle progression from G1 to S, through S, and G2 to M phase. Both inhibition and aberrant activation of CDK1/2 can be detrimental to cancer cell growth. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3e15bbdf6ae6edf2e75bad783f8461
https://doi.org/10.1080/15384101.2016.1160983

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A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase

Autor: Ryan Montano, Alan Eastman, Nandini Sakurikar, Ruth Thompson

Publikováno v: Oncotarget

DNA damage activates Checkpoint kinase 1 (Chk1) to halt cell cycle progression thereby preventing further DNA replication and mitosis until the damage has been repaired. Consequently, Chk1 inhibitors have emerged as promising anticancer therapeutics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6df456bb5c98b2f556aabb5037af204
https://doi.org/10.18632/oncotarget.6364

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Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival

Autor: Joshua M. Eichhorn, Timothy C. Chambers, Nandini Sakurikar, Sarah E. Alford

Publikováno v: Experimental Cell Research. 322:415-424

Bcl-2 family proteins act as essential regulators and mediators of intrinsic apoptosis. Several lines of evidence suggest that the anti-apoptotic members of the family, including Bcl-2, Bcl-xL and Mcl-1, exhibit functional redundancy. However, the cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88501db421e5831cc5616efe74ecf1f8
https://doi.org/10.1016/j.yexcr.2014.02.010

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Identification of a mitotic death signature in cancer cell lines

Autor: Joshua M. Eichhorn, Sarah E. Alford, Timothy C. Chambers, Nandini Sakurikar

Publikováno v: Cancer Letters. 343:232-238

This study examined the molecular mechanism of action of anti-mitotic drugs. The hypothesis was tested that death in mitosis occurs through sustained mitotic arrest with robust Cdk1 signaling causing complete phosphorylation of Mcl-1 and Bcl-xL, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc936e30d1c47aac9f700c62a0945bc
https://doi.org/10.1016/j.canlet.2013.09.036

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Cyclin-dependent Kinase-1 (Cdk1)/Cyclin B1 Dictates Cell Fate after Mitotic Arrest via Phosphoregulation of Antiapoptotic Bcl-2 Proteins

Autor: Timothy C. Chambers, Nandini Sakurikar, Joshua M. Eichhorn

Publikováno v: Journal of Biological Chemistry. 287:39193-39204

The prevailing model suggests that cell fate after mitotic arrest depends on two independent and competing networks that control cyclin B1 degradation and the generation of death signals. However, recent evidence for Cdk1/cyclin B1-mediated phosphory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786ea0dfa02db749212958f174f5f32a
https://doi.org/10.1074/jbc.m112.391854

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