Výsledky vyhledávání - "Nandini Pal Basak"

Akademický článek

Tumor histoculture captures the dynamic interactions between tumor and immune components in response to anti-PD1 in head and neck cancer

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Dynamic interactions within the tumor micro-environment drive patient response to immune checkpoint inhibitors. Existing preclinical models lack true representation of this complexity. Using a Head and Neck cancer patient derived TruTumor hi

Externí odkaz: https://doaj.org/article/9dbb8fcc65214595a787b6c11342d00b

Zobrazit plný text záznamu

Abstract 4568: Evaluating response of renal cell carcinoma to tyrosine kinase inhibitor and immune checkpoint inhibitor using a human histo-culture platform

Autor: Satish Sankaran, Kowshik Jaganathan, Gowri Shankar K, Saurabh Bhargav, Ganesh MS, Amritha Prabha, Prakash BV, Syamkumar V, Biswajit Das, Vasanth K, Manimaran A, Chandan Bhowal, Rajashekar M, Oliyarasi M, Ritu Malhotra, Govindraj K, Nandini Pal Basak

Publikováno v: Cancer Research. 83:4568-4568

Tyrosine Kinase Inhibitors (TKIs) and Immune checkpoint inhibitors (ICIs) are used in first line treatment of clear cell renal cell carcinoma (ccRCC). Identifying patients who truly benefit from these treatments remains a challenge. Developing newer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::806d2c2b988dfa5456d9a091157202b6
https://doi.org/10.1158/1538-7445.am2023-4568

Zobrazit plný text záznamu

34 Selective infiltration of Antibody-Dependent Cellular Cytoxicity (ADCC) mediating immune cells in response to treatment in a human tumor histo-culture platform

Autor: BV Prakash, A Manimaran, M Oliyarasi, M Rajashekar, Ritu Malhotra, Ganesh, K Gowri Shankar, BV Manjula, Krishnan Vasanth, Satish Sankaran, Kowshik Jaganathan, Rachita Rao, Nandini Pal Basak, Sindhu Govindan, Amritha Prabha

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundA 3D histo-culture platform provides a near native Tumor immune Micro-Environment (TiME), making it best suited for evaluating response to immunotherapy drugs. Farcast™ TiME is a human 3D tumor histo-culture platform that preserves TiME a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e619607b624be0ac5e60057174ab01
https://doaj.org/article/fa741d849d444f21960e8e19e0969f79

Zobrazit plný text záznamu

Abstract 2767: Understanding the functional fidelity of tumor infiltrated leukocytes (TILs) in a human tumor histo-culture platform

Autor: Ritu Malhotra, Satish Sankaran, Kowshik Jaganathan, Sindhu Govindan, Nandini Pal Basak, Vasanth K, Pradeep Kumar Kar, Rachita Rao

Publikováno v: Cancer Research. 81:2767-2767

There is an unmet need for robust and accurate preclinical model to minimize translational failure especially in immuno-oncology (IO) research. The poor correlation between preclinical data with clinical trials remains a major concern. A near native

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::585253d4ac69036385f3ebd943c4159e
https://doi.org/10.1158/1538-7445.am2021-2767

Zobrazit plný text záznamu

Abstract 4990: Flow cytometric characterization of the tumor-infiltrating immune compartment: Significant differences in the tumor immune repertoire versus peripheral blood

Autor: Jason Wall, Manimaran Manickam, Nandini Pal Basak, Misti Jain, Sampratha Bhagyashekar, Anupam Nath, Shivani Vignesh, Debika Datta

Publikováno v: Cancer Research. 80:4990-4990

Characterization of the tumor microenvironment (TME) is expected to be critical in informing prognosis and guiding response prediction1,2. Recent studies have classified the TME based on tumor infiltrating leukocytes (TILs), programmed death-ligand 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be4602a845a843c20b5a3fbf35de7385
https://doi.org/10.1158/1538-7445.am2020-4990

Zobrazit plný text záznamu

Mitochondrial dependency in progression of acute myeloid leukemia

Autor: Nandini Pal Basak, Subrata Banerjee

Publikováno v: Mitochondrion. 21:41-48

Acute myeloid leukemia (AML) is a clonal hematopoietic malignant disorder which arises due to dysregulated differentiation, uncontrolled growth and inhibition of apoptosis leading to the accumulation of immature myeloid progenitor in the bone marrow.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d1dbfc707ad3220b706973c037f312
https://doi.org/10.1016/j.mito.2015.01.006

Zobrazit plný text záznamu

Alteration of Mitochondrial Proteome Due to Activation of Notch1 Signaling Pathway

Autor: Anita Roy, Nandini Pal Basak, Subrata Banerjee

Publikováno v: Journal of Biological Chemistry. 289:7320-7334

The Notch signaling pathway, a known regulator of cell fate decisions, proliferation, and apoptosis, has recently been implicated in the regulation of glycolysis, which affects tumor progression. However, the impact of Notch on other metabolic pathwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3815619e41433bddcd8a782a8fc714
https://doi.org/10.1074/jbc.m113.519405

Zobrazit plný text záznamu

Molecular cross talk between Notch1, Shh and Akt pathways during erythroid differentiation of K562 and HEL cell lines

Autor: Anita Roy, Srijan Haldar, Nandini Pal Basak, Subrata Banerjee

Publikováno v: Experimental Cell Research. 320:69-78

Erythropoiesis is a tightly regulated process dependent on extrinsic signals conveyed by the bone marrow niche. The signalling pathways thus activated or repressed do not act in isolation; rather an intricate cross talk among these pathways ensues ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf7737dfcc2b3cf97595361455a425d
https://doi.org/10.1016/j.yexcr.2013.09.019

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání