Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nandini Chaturbhai Patel"'
Autor:
Nandini Chaturbhai Patel, Dafydd R. Owen, Rhonda D. Cardin, Karen J. Coffman, Jean G. Sathish, Devendra K. Rai, Heather Eng, Charlotte Moira Norfor Allerton, Jack C. Lee, Britton Boras, Melissa Avery, Qingyi Yang, Eugene P. Kadar, Anthony Carlo, Annaliesa S. Anderson, Matthew R. Reese, Li Di, Jisun Lee, Lisa Aschenbrenner, Stephen Noell, Lawrence W. Updyke, Martin Pettersson, Scott A. Gibson, Matthew F. Sammons, Al E. Stewart, Yuao Zhu, Alyssa Dantonio, Stephen W. Mason, Brett L. Hurst, Ketan S. Gajiwala, Claire M. Steppan, Liuqing Wei, Patrick Robert Verhoest, Samantha Elizabeth Greasley, Simon Berritt, R. Scott Obach, RoseAnn Ferre, Ravi Shankar P. Singh, Amit S. Kalgutkar, Jonathan J. Novak, Kevin Ogilvie, Wei Liu, Jamison B. Tuttle
Publikováno v:
Science. 374:1586-1593
Path to another drug against COVID-19 The rapid development of vaccines has been crucial in battling the ongoing COVID-19 pandemic. However, access challenges remain, breakthrough infections occur, and emerging variants present increased risk. Develo
Autor:
Alyssa Dantonio, Heather Eng, Nandini Chaturbhai Patel, Anthony Carlo, Liuqing Wei, Annaliesa S. Anderson, Ravi Shankar P. Singh, Lawrence W. Updyke, Amit S. Kalgutkar, Jamison B. Tuttle, Lisa Aschenbrenner, Simon Berritt, Ketan S. Gajiwala, Jack C. Lee, Devendra K. Rai, Martin Pettersson, Matthew R. Reese, Jisun Lee, Stephen W. Mason, Eugene P. Kadar, RoseAnn Ferre, Melissa Avery, Li Di, Charlotte Moira Norfor Allerton, R. Scott Obach, Scott A. Gibson, Stephen Noell, Patrick Robert Verhoest, Kevin Ogilvie, Jonathan J. Novak, Brett L. Hurst, Dafydd R. Owen, Rhonda D. Cardin, Wei Liu, Yuao Zhu, Karen J. Coffman, Claire M. Steppan, Jean G. Sathish, Samantha Elizabeth Greasley, Matthew F. Sammons, Qingyi Yang, Britton Boras, Al E. Stewart
The worldwide outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become an established global pandemic. Alongside vaccines, antiviral therapeutics are an important part of the he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0de6febfa535f3995194517e34278b9
https://doi.org/10.1101/2021.07.28.21261232
https://doi.org/10.1101/2021.07.28.21261232
Autor:
Bo Feng, Mark A. West, Jennifer L. Liras, Travis T. Wager, Nandini Chaturbhai Patel, Larry M. Tremaine, Jillian G. Johnson, Xinjun Hou
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2476-2483
It is of great challenge to predict human brain penetration for substrates of multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), 2 major efflux transporters at blood-brain barrier. Thus, a physiologically based pharmac
Autor:
Nandini Chaturbhai Patel, Jennifer L. Liras, Patrick Trapa, Mark A. West, Tristan S. Maurer, Bo Feng, Patrick Robert Verhoest, Simone Sciabola, Travis T. Wager, Xinjun Hou
Publikováno v:
ACS chemical neuroscience. 12(6)
One of the objectives within the medicinal chemistry discipline is to design tissue targeting molecules. The objective of tissue specificity can be either to gain drug access to the compartment of interest (e.g., the CNS) for Neuroscience targets or
Publikováno v:
Medicinal Chemistry Reviews ISBN: 9780996293280
Medicinal Chemistry Reviews
Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2113123b86f200bb066aa8b3d91ed32
https://doi.org/10.29200/acsmedchemrev-v54.ch19
https://doi.org/10.29200/acsmedchemrev-v54.ch19
Autor:
Nandini Chaturbhai Patel, Richard V. Coelho, Christopher John Helal, Chewah Lee, Anabella Villalobos, Shawn D. Doran, Joseph Michael Young, Robert J. Mather, Simone Sciabola, Erik Alphie Lachapelle, John T. Lazzaro, Thomas Allen Chappie, Patrick Robert Verhoest, Zoë A. Hughes, Marc B. Skaddan, Elizabeth Mary Beck, John M. Humphrey, Kyle Kuszpit, Laigao Chen, Lei Zhang, Kenneth R. Zasadny, Kuo-Hsien Fan
Publikováno v:
Journal of Medicinal Chemistry. 60:8538-8551
As part of our effort in identifying phosphodiesterase (PDE) 4B-preferring inhibitors for the treatment of central nervous system (CNS) disorders, we sought to identify a positron emission tomography (PET) ligand to enable target occupancy measuremen
Autor:
Nandini Chaturbhai Patel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127503
Among the most devastating disorders of our time, neurologic and psychiatric diseases combine to cause more disability than any other disease area. One of the key objectives within the medicinal chemistry discipline is to design molecules that penetr
Autor:
Anthony Carlo, Bo Feng, Mark A. West, Jennifer L. Liras, Nandini Chaturbhai Patel, Thomas Y. K. Lau, Travis T. Wager, Matthew D. Troutman, Patrick Trapa, John P. Umland, Tristan S. Maurer
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 47(4)
Understanding the quantitative implications of P-glycoprotein and breast cancer resistance protein efflux is a key hurdle in the design of effective, centrally acting or centrally restricted therapeutics. Previously, a comprehensive physiologically b
Autor:
Raymond S. Hurst, Mihály Hajós, Dennis J. Hoover, William E. Hoffmann, Nandini Chaturbhai Patel, Christopher L. Shaffer, Xinjun J. Hou, Christopher J. O’Donnell, Dina McGinnis, Jayvardhan Pandit, Eric S. Marr, Randall James Gallaschun, Dianne K. Bryce, John T. Lazzaro, Longfei Xie, Jacob Bradley Schwarz, Fliri Anton F J, Justin L Gazard, Ashley N. Hanks, Renato J. Scialis
Publikováno v:
Journal of Medicinal Chemistry. 56:9180-9191
Positive allosteric modulators ("potentiators") of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR) enhance excitatory neurotransmission and may improve the cognitive deficits associated with various neurological disorde
Autor:
Jean S. Beebe, William M. Hungerford, Nandini Chaturbhai Patel, Heather N. Frost, Susan Deborah Lagreca, Cathy Soderstrom, Shefali Kakar, Doug Savage, Matthew David Wessel, Matthew A. Marx, Merin Boehm, Thompson Carl Brian, Jinshan M. Chen, Connell Richard D, Nandell F. Keene, Elizabeth Knauth, Gary Borzillo, Aaron Kanter, Yong Lu, Joel Morris, Martin A. Berliner, Patrick Vincent, Bruce D. Cohen, George T. Tkalcevic, Joel T. Arcari, Deborah A. Gordon, James J. Valentine, Tracey Clark, Louis Martinez-Alsina, Vincent Bernardo, Felix Vajdos, Norma Jacqueline Tom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3059-3063
The synthesis and biological evaluation of novel Tie-2 kinase inhibitors are presented. Based on the pyrrolopyrimidine chemotype, several new series are described, including the benzimidazole series by linking a benzimidazole to the C5-position of th