Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Nandini, Kishore"'
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1979 Jun 01. 76(6), 2708-2711.
Externí odkaz:
https://www.jstor.org/stable/69841
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1981 Dec 01. 78(12), 7299-7303.
Externí odkaz:
https://www.jstor.org/stable/11186
Publikováno v:
The Journal of Cell Biology, 1980 Jun 01. 85(3), 910-915.
Externí odkaz:
https://www.jstor.org/stable/1609062
Autor:
Dean Wilkie, Chris S. Bollinger, Nandini Kishore, Peter T. Symanowicz, Martin Hegen, Richard D. Head, Fernando A. Happa, Zaher A. Radi, Zachary S. Stewart, Sheri L. Bonar, Jeremy W. Wellen, Yutian Zhan, Janice M. Thompson, Timothy P. LaBranche, Michael I. Jesson, Prashant N. Bansal, Steven Bailey, Debra M. Meyer, Gabriel Mbalaviele, Julia A. Guzova, Chad E. Storer
Publikováno v:
Arthritis & Rheumatism. 64:3531-3542
Objective The mechanistic link between Janus kinase (JAK) signaling and structural damage to arthritic joints in rheumatoid arthritis (RA) is poorly understood. This study was undertaken to investigate how selective inhibition of JAK with tofacitinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9ae849dbd56f0e81d8c0d499727b29
https://doi.org/10.1002/art.34649
https://doi.org/10.1002/art.34649
Autor:
Jason W. Alsup, Michael I. Jesson, Jamie L. Lee, Craig J. Thomas, Richard D. Head, Martin E. Dowty, Zaher A. Radi, Scott M. Steward-Tharp, Kamran Ghoreschi, John J. O'Shea, Masao Tanaka, Debra M. Meyer, Timothy P. LaBranche, Chad E. Storer, Massimo Gadina, Xiong Li, James D. Warner, Sarbani Ghosh, Nandini Kishore, John C. Minnerly
Publikováno v:
The Journal of Immunology. 186:4234-4243
Inhibitors of the JAK family of nonreceptor tyrosine kinases have demonstrated clinical efficacy in rheumatoid arthritis and other inflammatory disorders; however, the precise mechanisms by which JAK inhibition improves inflammatory immune responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867e38b4b0776579af2b2e09797a2c24
https://doi.org/10.4049/jimmunol.1003668
https://doi.org/10.4049/jimmunol.1003668
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 23:172-181
Rationale IκB kinase (IKK) activates NF-κB which plays a pivotal role in pro-inflammatory response in the lung. NF-κB has been shown to be activated in alveolar macrophages and peripheral lungs of smokers and patients with chronic obstructive pulm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c6c6b8d5c03fd453465550525bb374
https://doi.org/10.1016/j.pupt.2010.01.002
https://doi.org/10.1016/j.pupt.2010.01.002
Publikováno v:
Journal of Pharmaceutical Sciences. 99:1278-1287
NF-κB activation is clearly linked to the pathogenesis of multiple inflammatory diseases including arthritis. The prominent role of IκB kinase-2 (IKK-2) in regulating NF-κB signaling in response to proinflammatory stimuli has made IKK-2 a primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef905b762d1f55750a274c625559778c
https://doi.org/10.1002/jps.21909
https://doi.org/10.1002/jps.21909
Autor:
Julia A. Guzova, Gabriel Mbalaviele, Alexander F. Shaffer, Sheri L. Bonar, John F. Schindler, David C. Thompson, Nandini Kishore, Catherine S. Tripp, Cynthia D. Sommers, Yiding Hu, Sumathy Mathialagan, Po Chang Chiang, Michele A. Melton, Lori Christine
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 329:14-25
Nuclear factor (NF)-kappaB activation has been clearly linked to the pathogenesis of multiple inflammatory diseases including arthritis. The central role that IkappaB kinase-2 (IKK-2) plays in regulating NF-kappaB signaling in response to inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88dfc2562c02b4aed4c1440b261119e
https://doi.org/10.1124/jpet.108.143800
https://doi.org/10.1124/jpet.108.143800
Autor:
Sheri L. Bonar, Adam Libby, Yao Min, Richard Weier, Michael B. Tollefson, Serge G. Wolfson, Michael Clare, Ann M. Donnelly, William E. Mcghee, Dominique Bonafoux, Patrick J. Lennon, Sumathy Mathialagan, Julia A. Guzova, Nandini Kishore, Cindy Sommers, Sharon Rouw, Lori Christine, Catherine S. Tripp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2870-2875
A series of 21 novel 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides were synthesized and evaluated for the inhibition of IKK-2. In spite of their often modest activity on the enzyme, six selected analogs showed significant inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752b9930690fa8fa16c025496d6ce863
https://doi.org/10.1016/j.bmcl.2005.03.090
https://doi.org/10.1016/j.bmcl.2005.03.090
Autor:
Srinivasan Nagarajan, Gary Anthony De Crescenzo, James A. Sikorski, Getman Daniel P, Jeffrey L Walker, Lisa Blystone, Christie L Funkes-Shippy, Nandini Kishore, Pramod P. Mehta, Kathryn A Houseman, Geralyn P. Kocan, Hwang Fun Lu, Joseph J. McDonald
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:4769-4777
The human immunodeficiency virus (HIV) has been shown to be the causative agent for AIDS. The HIV virus encodes for a unique aspartyl protease that is essential for the production of enzymes and proteins in the final stages of maturation. Protease in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e41f7ee8ade0e21d88ea525341587f
https://doi.org/10.1016/j.bmc.2003.07.001
https://doi.org/10.1016/j.bmc.2003.07.001