Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells

Autor: Gautier Follain, Naël Osmani, Valentin Gensbittel, Nandini Asokan, Annabel Larnicol, Luc Mercier, Maria Jesus Garcia-Leon, Ignacio Busnelli, Angelique Pichot, Nicodème Paul, Raphaël Carapito, Seiamak Bahram, Olivier Lefebvre, Jacky G. Goetz

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract Tumor progression and metastatic dissemination are driven by cell-intrinsic and biomechanical cues that favor the growth of life-threatening secondary tumors. We recently identified pro-metastatic vascular regions with blood flow profiles th

Externí odkaz: https://doaj.org/article/6130e5f27801400da5a956453d118a77

Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

Autor: Shima Ghoroghi, Benjamin Mary, Annabel Larnicol, Nandini Asokan, Annick Klein, Naël Osmani, Ignacio Busnelli, François Delalande, Nicodème Paul, Sébastien Halary, Frédéric Gros, Laetitia Fouillen, Anne-Marie Haeberle, Cathy Royer, Coralie Spiegelhalter, Gwennan André-Grégoire, Vincent Mittelheisser, Alexandre Detappe, Kendelle Murphy, Paul Timpson, Raphaël Carapito, Marcel Blot-Chabaud, Julie Gavard, Christine Carapito, Nicolas Vitale, Olivier Lefebvre, Jacky G Goetz, Vincent Hyenne

Publikováno v: eLife, Vol 10 (2021)

Cancer extracellular vesicles (EVs) shuttle at distance and fertilize pre-metastatic niches facilitating subsequent seeding by tumor cells. However, the link between EV secretion mechanisms and their capacity to form pre-metastatic niches remains obs

Externí odkaz: https://doaj.org/article/8b6c4beb19a94bea955052e913d775d6

Preclinical evaluation of platinum-loaded hydroxyapatite nanoparticles in an embryonic zebrafish xenograft model

Autor: Robin A. Nadar, Alessandra Barbanente, Lorenzo Degli Esposti, Michele Iafisco, Martin Bornhäuser, Jeroen J.J.P. van den Beucken, Uwe Karst, Lukas Schlatt, Nicola Margiotta, Michael Brand, Alessandra Curci, Nandini Asokan, Sander C.G. Leeuwenburgh

Publikováno v: Nanoscale, 12, 25, pp. 13582-13594
Nanoscale
12 (2020): 13582–13594. doi:10.1039/d0nr04064a
info:cnr-pdr/source/autori:Nadar, Robin A.; Asokan, Nandini; Degli Esposti, Lorenzo; Curci, Alessandra; Barbanente, Alessandra; Schlatt, Lukas; Karst, Uwe; Iafisco, Michele; Margiotta, Nicola; Brand, Michael; van den Beucken, Jeroen J. J. P.; Bornhaeuser, Martin; Leeuwenburg, Sander C. G./titolo:Preclinical evaluation of platinum-loaded hydroxyapatite nanoparticles in an embryonic zebrafish xenograft model/doi:10.1039%2Fd0nr04064a/rivista:Nanoscale (Print)/anno:2020/pagina_da:13582/pagina_a:13594/intervallo_pagine:13582–13594/volume:12
Nanoscale, 12, 13582-13594

Hydroxyapatite (HA) nanoparticles are commonly used as building blocks in the design of bone-substituting biomaterials. Recently, these nanoparticles have been considered for the treatment of metastasis disease, since their pH-dependent dissolution b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75927a0d3647fdef0a24e864ecfa3ffe
https://hdl.handle.net/2066/221558

Author response: Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

Autor: Coralie Spiegelhalter, Frédéric Gros, Anne-Marie Haeberlé, Ignacio Busnelli, Christine Carapito, Vincent Mittelheisser, Nicolas Vitale, Jacky G. Goetz, Marcel Blot-Chabaud, Julie Gavard, Laetitia Fouillen, Paul Timpson, Nandini Asokan, Gwennan André-Grégoire, Alexandre Detappe, Raphael Carapito, Benjamin Mary, Olivier Lefebvre, Naël Osmani, Shima Ghoroghi, Kendelle J. Murphy, Nicodème Paul, Annabel Larnicol, Vincent Hyenne, Annick Klein, Catherine A. Royer, Sébastien Halary, François Delalande

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::873484f7d81de6154434e6c434004610
https://doi.org/10.7554/elife.61539.sa2

Targeting of radioactive platinum-bisphosphonate anticancer drugs to bone of high metabolic activity

Autor: Otto C. Boerman, Sandra Heskamp, Uwe Karst, Nicola Margiotta, Michele Iafisco, Michael Brand, Martin Bornhaeuser, Karlijn Codee-van der Schilden, Nandini Asokan, Barbara Crone, Robin A. Nadar, Sander C.G. Leeuwenburgh, Kambiz Farbod, Alessandra Curci, Jeroen J.J.P. van den Beucken, Lukas Schlatt

Publikováno v: Scientific Reports
Scientific Reports, 10
Scientific reports (Nature Publishing Group) 10 (2020). doi:10.1038/s41598-020-62039-2
info:cnr-pdr/source/autori:Nadar, Robin A.; Farbod, Kambiz; Codee-van der Schilden, Karlijn; Schlatt, Lukas; Crone, Barbara; Asokan, Nandini; Curci, Alessandra; Brand, Michael; Bornhaeuser, Martin; Iafisco, Michele; Margiotta, Nicola; Karst, Uwe; Heskamp, Sandra; Boerman, Otto C.; van den Beucken, Jeroen J. J. P.; Leeuwenburgh, Sander C. G./titolo:Targeting of radioactive platinum-bisphosphonate anticancer drugs to bone of high metabolic activity/doi:10.1038%2Fs41598-020-62039-2/rivista:Scientific reports (Nature Publishing Group)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)

Platinum-based chemotherapeutics exhibit excellent antitumor properties. However, these drugs cause severe side effects including toxicity, drug resistance, and lack of tumor selectivity. Tumor-targeted drug delivery has demonstrated great potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d7e7c905a9014f0fc7e87c4b67eae5
http://europepmc.org/articles/PMC7125202