Cellular and metabolic reprogramming in breast cancer and its therapeutic implications

Autor: Nandi, Ipshita

Externí odkaz: https://escholarship.mcgill.ca/concern/theses/3197xs110

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An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic 2 reprogramming and mammary tumourigenesis

Autor: Smith, Harvey W, Hirukawa, Alison, Sanguin-Gendreau, Virginie, Nandi, Ipshita, Dufour, Catherine R, Zuo, Dongmei, Tandoc, Kristofferson, Leibovitch, Matthew, Singh, Salendra, Rennhack, Jonathan, Swiatnicki, Matthew, Lavoie, Cynthia, Papavasiliou, Vasilios, Temps, Carolin, Carragher, Neil, Unciti-Broceta, Asier, Savage, Paul, Basik, Mark, van Hoef, Vincent, Larsson, Ola, Cooper, Caroline L, Calderon, Ana Cristina Vargas, Beith, Jane, Millar, Ewan, Selinger, Christina, Giguère, Vincent, Park, Morag, Harris, Lyndsey R, Varadan, Vinay, Andrechek, Eran, O'Toole, Sandra A, Topisirovic, Ivan, Muller, William J

Publikováno v: Smith, H W, Hirukawa, A, Sanguin-Gendreau, V, Nandi, I, Dufour, C R, Zuo, D, Tandoc, K, Leibovitch, M, Singh, S, Rennhack, J, Swiatnicki, M, Lavoie, C, Papavasiliou, V, Temps, C, Carragher, N, Unciti-Broceta, A, Savage, P, Basik, M, van Hoef, V, Larsson, O, Cooper, C L, Calderon, A C V, Beith, J, Millar, E, Selinger, C, Giguère, V, Park, M, Harris, L R, Varadan, V, Andrechek, E, O'Toole, S A, Topisirovic, I & Muller, W J 2019, ' An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic 2 reprogramming and mammary tumourigenesis ', Nature Communications . https://doi.org/10.1038/s41467-019-10681-4

Dysregulation of histone modifications promotes carcinogenesis by altering transcription. Breast cancers frequently overexpress the histone methyltransferase EZH2, the catalytic subunit of Polycomb Repressor Complex 2 (PRC2). However, the role of EZH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::02577d115160bd49655e9dec3d10a333
https://hdl.handle.net/20.500.11820/f8ed5961-3469-4b56-a87f-2b4be06c7021