Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nandell F. Keene"'
Autor:
Yong Tao, J. Christopher McWilliams, Wiglesworth Kristin, Barbara J. Sitter, Nandell F. Keene
Publikováno v:
Organic Process Research & Development. 23:382-388
The original synthesis of the irreversible epidermal growth factor receptor (EGFR) T790 M inhibitor 1 was enabled by successful application of ammonium hydroxide to cleanly cleave the N-hydroxymeth...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4871fa7d86c6c482e5d9dabd16b30df2
https://doi.org/10.1021/acs.oprd.8b00437
https://doi.org/10.1021/acs.oprd.8b00437
Autor:
Daniel W. Widlicka, Nathan E. Genung, Jana Polivkova, Daniel W. Kung, Wiglesworth Kristin, Thomas Andrew Brandt, Jun Xiao, Matthew S. Dowling, Yingxin Zhang, Paul M. Herrinton, David J. Edmonds, Todd Zahn, Ka Ning Yip, Colin R. Rose, Qifang Li, Jane Panteleev, Shawn Cabral, Andre Shavnya, Nandell F. Keene, John D. Weaver, Benjamin A. Thuma, Michael Herr, Ian Edmonds, Gary Erik Aspnes, Guoqiang Wang, Philip D. Dent, Dilinie P. Fernando, Aaron C. Smith, Michael G. Vetelino, Sophie Y. Lavergne, Edward L. Conn
Publikováno v:
Organic Process Research & Development. 22:681-696
Indole acids 1, 2, and 3 are potent 5′-adenosine monophosphate-activated protein kinase (AMPK) activators for the potential treatment of diabetic nephropathy. Compounds 1–3 were scaled to supply material for preclinical studies, and indole 3 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b628a560af69b1edadd146b3a36513be
https://doi.org/10.1021/acs.oprd.8b00059
https://doi.org/10.1021/acs.oprd.8b00059
Autor:
Jean S. Beebe, William M. Hungerford, Nandini Chaturbhai Patel, Heather N. Frost, Susan Deborah Lagreca, Cathy Soderstrom, Shefali Kakar, Doug Savage, Matthew David Wessel, Matthew A. Marx, Merin Boehm, Thompson Carl Brian, Jinshan M. Chen, Connell Richard D, Nandell F. Keene, Elizabeth Knauth, Gary Borzillo, Aaron Kanter, Yong Lu, Joel Morris, Martin A. Berliner, Patrick Vincent, Bruce D. Cohen, George T. Tkalcevic, Joel T. Arcari, Deborah A. Gordon, James J. Valentine, Tracey Clark, Louis Martinez-Alsina, Vincent Bernardo, Felix Vajdos, Norma Jacqueline Tom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3059-3063
The synthesis and biological evaluation of novel Tie-2 kinase inhibitors are presented. Based on the pyrrolopyrimidine chemotype, several new series are described, including the benzimidazole series by linking a benzimidazole to the C5-position of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4094fb50746e9612e49cef7a5bc7bf6
https://doi.org/10.1016/j.bmcl.2013.03.012
https://doi.org/10.1016/j.bmcl.2013.03.012
Autor:
Matthew David Wessel, Martin A. Berliner, Michael Joseph Luzzio, Nandell F. Keene, John Charles Kath, Daniel Tyler Richter
Publikováno v:
Tetrahedron Letters. 54:4610-4612
A variety of 2,4-diamino-pyrimidine systems can be prepared from the corresponding 2,4-dichloro-pyrimidine by sequential addition of two amines, the first adding selectively to the 4-position. In contrast it was found that 2,4-dichloro-5-trifluoromet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::432160f835cdce1e06ce729ad6636f12
https://doi.org/10.1016/j.tetlet.2013.06.025
https://doi.org/10.1016/j.tetlet.2013.06.025
Autor:
Chiu Charles K, Ronald Morris, Silke Wunderwald, Kyle R. Leeman, Richard A. Buzon, Tung Le, Nandell F. Keene, Takushi Kaneko, Zhongli Zhang, Lisa Newell, John D. Weaver, Stephen T. Colgan, Michael F. Witt, Brian L. Marquez, William Kissel, Bryan Li, Martin A. Berliner, Zhijun Zhang
Publikováno v:
The Journal of organic chemistry. 71(24)
Aqueous phosphoric acid (85 wt %) is an effective, environmentally benign reagent for the deprotection of tert-butyl carbamates, tert-butyl esters, and tert-butyl ethers. The reaction conditions are mild and offer good selectivity in the presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16585cc97001c77a93d0d6018913b0aa
https://pubmed.ncbi.nlm.nih.gov/17109528
https://pubmed.ncbi.nlm.nih.gov/17109528
Autor:
Lori L. Lopresti-Morrow, Kevin Daniel Freeman-Cook, Joel R. Hardink, Elaine M. Greer, Amy S. Antipas, Gary J. Martinelli, Jennifer L. Liras, Fouad Janat, Donald G. Robertson, Jayvardhan Pandit, Kaushik Datta, Sue A. Yocum, James T. Downs, Darra M. Waller, Diana Sperger, Lawrence A. Reiter, Ellen R. Laird, Martin A. Berliner, Peter G. Mitchell, Michael D. Forman, Marcie L. Vaughn-Bowser, James D. Eskra, Nandell F. Keene, Roberto E. Guzman, Christopher S. Jones
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(22)
Using SAR from two related series of pyrimidinetrione-based inhibitors, compounds with potent MMP-13 inhibition and >100-fold selectivity against other MMPs have been identified. Despite high molecular weights, c log Ps, and polar surface areas, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a677dbc57c5181a3a9927f482718a66
https://pubmed.ncbi.nlm.nih.gov/16942871
https://pubmed.ncbi.nlm.nih.gov/16942871