Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Nandan S. Gokhale"'
Autor:
Brian V. Tsu, Rimjhim Agarwal, Nandan S. Gokhale, Jessie Kulsuptrakul, Andrew P. Ryan, Elizabeth J. Fay, Lennice K. Castro, Christopher Beierschmitt, Christina Yap, Elizabeth A. Turcotte, Sofia E. Delgado-Rodriguez, Russell E. Vance, Jennifer L. Hyde, Ram Savan, Patrick S. Mitchell, Matthew D. Daugherty
Publikováno v:
PLoS Biology, Vol 21, Iss 6 (2023)
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CLpro) encoded by diverse c
Externí odkaz:
https://doaj.org/article/5dd514c3e9364ba18c660907120ad774
Autor:
Alexander M. Price, Katharina E. Hayer, Alexa B. R. McIntyre, Nandan S. Gokhale, Jonathan S. Abebe, Ashley N. Della Fera, Christopher E. Mason, Stacy M. Horner, Angus C. Wilson, Daniel P. Depledge, Matthew D. Weitzman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Adenovirus transcripts contain N6-methyladenosine (m6A) modification. Here the authors profile m6A modification sites on adenovirus mRNAs using Illumina meRIP-Seq and nanopore direct RNA sequencing, and showcase a role for m6A in splicing of viral la
Externí odkaz:
https://doaj.org/article/3a519d8fdd744f07aceaf2a7bd692439
Publikováno v:
mSphere, Vol 5, Iss 3 (2020)
ABSTRACT Type I interferons (IFN) initiate an antiviral state through a signal transduction cascade that leads to the induction of hundreds of IFN-stimulated genes (ISGs) to restrict viral infection. Recently, RNA modifications on both host and viral
Externí odkaz:
https://doaj.org/article/03799356559a46dd974db83f9190f76f
Autor:
Frank W Soveg, Johannes Schwerk, Nandan S Gokhale, Karen Cerosaletti, Julian R Smith, Erola Pairo-Castineira, Alison M Kell, Adriana Forero, Shivam A Zaver, Katharina Esser-Nobis, Justin A Roby, Tien-Ying Hsiang, Snehal Ozarkar, Jonathan M Clingan, Eileen T McAnarney, Amy EL Stone, Uma Malhotra, Cate Speake, Joseph Perez, Chiraag Balu, Eric J Allenspach, Jennifer L Hyde, Vineet D Menachery, Saumendra N Sarkar, Joshua J Woodward, Daniel B Stetson, John Kenneth Baillie, Jane H Buckner, Michael Gale Jr, Ram Savan
Publikováno v:
eLife, Vol 10 (2021)
Many host RNA sensors are positioned in the cytosol to detect viral RNA during infection. However, most positive-strand RNA viruses replicate within a modified organelle co-opted from intracellular membranes of the endomembrane system, which shields
Externí odkaz:
https://doaj.org/article/3265b04191644b45bacaf4c20c760cca
Autor:
Nicholas W. Hubbard, Joshua M. Ames, Megan Maurano, Lan H. Chu, Kim Y. Somfleth, Nandan S. Gokhale, Margo Werner, Jessica M. Snyder, Katrina Lichauco, Ram Savan, Daniel B. Stetson, Andrew Oberst
Publikováno v:
Nature. 607:769-775
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The genomes of RNA viruses encode the information required for replication in host cells both in their linear sequence and in complex higher-order structures. A subset of these RNA genome structures show clear sequence conservation, and have been ext
The genomes of RNA viruses encode the information required for replication in host cells in both their linear sequence and in complex higher-order structures. A subset of these complex functional RNA genome structures show clear sequence conservation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3a8c406d5417a61023b80aaf1799427
https://doi.org/10.1101/2022.10.10.511575
https://doi.org/10.1101/2022.10.10.511575
Autor:
Brian V. Tsu, Rimjhim Agarwal, Nandan S. Gokhale, Jessie Kulsuptrakul, Andrew P. Ryan, Lennice K. Castro, Christopher M. Beierschmitt, Elizabeth A. Turcotte, Elizabeth J. Fay, Russell E. Vance, Jennifer L. Hyde, Ram Savan, Patrick S. Mitchell, Matthew D. Daugherty
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CLpro) encoded by diverse c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60961e6666e00b8cd2dfdf2b6cf1f3f9
https://doi.org/10.1101/2022.09.21.508960
https://doi.org/10.1101/2022.09.21.508960
Publikováno v:
Immunol Rev
From the initial sensing of viral nucleotides by pattern recognition receptors, through the induction of type I and III interferons (IFN), upregulation of antiviral effector proteins, and resolution of the inflammatory response, each step of innate i
Autor:
Nandan S Gokhale, Stacy M Horner
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006188 (2017)
Externí odkaz:
https://doaj.org/article/f7e3bca0811b4621a2c9d567f76060b0