Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nandan Haloi"'
Autor:
Xiaodi Yu, Rosalie E. Matico, Robyn Miller, Dhruv Chauhan, Bertrand Van Schoubroeck, Karolien Grauwen, Javier Suarez, Beth Pietrak, Nandan Haloi, Yanting Yin, Gary John Tresadern, Laura Perez-Benito, Erik Lindahl, Astrid Bottelbergs, Daniel Oehlrich, Nina Van Opdenbosch, Sujata Sharma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The NACHT-, leucine-rich-repeat-, and pyrin domain-containing protein 3 (NLRP3) is a critical intracellular inflammasome sensor and an important clinical target against inflammation-driven human diseases. Recent studies have elucidated its t
Externí odkaz:
https://doaj.org/article/7f229443efb44bc9b6f041484b3699ef
Autor:
Nandan Haloi, Po-Chao Wen, Qunli Cheng, Meiying Yang, Gayathri Natarajan, Amadou K. S. Camara, Wai-Meng Kwok, Emad Tajkhorshid
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Haloi et al. investigate the role of the hydrophobic N-terminus of hexokinase II (HKII) in their binding to mitochondrial VDAC1. They use a hybrid approach combining molecular and Brownian dynamics to show that HKII first inserts into the outer membr
Externí odkaz:
https://doaj.org/article/9b0ee7be8cd74a3aaff79ae00681eddc
Autor:
Sonya Kumar Bharathkar, Benjamin W Parker, Andrey G Malyutin, Nandan Haloi, Kathryn E Huey-Tubman, Emad Tajkhorshid, Beth M Stadtmueller
Publikováno v:
eLife, Vol 9 (2020)
Secretory (S) Immunoglobulin (Ig) A is the predominant mucosal antibody, which binds pathogens and commensal microbes. SIgA is a polymeric antibody, typically containing two copies of IgA that assemble with one joining-chain (JC) to form dimeric (d)
Externí odkaz:
https://doaj.org/article/639c7ce5c0f14548a0fa279b02c67016
Autor:
Vasyl Bondarenko, Qiang Chen, Kevin Singewald, Nandan Haloi, Tommy S. Tillman, Rebecca J. Howard, Erik Lindahl, Yan Xu, Pei Tang
Publikováno v:
ACS Chemical Neuroscience. 14:1156-1165
Autor:
Nandan Haloi
These are the raw MD simulation data (water, ions and lipid removed) entitling the publication of "Structure and dynamics of differential ligand binding in the human ρ-type GABAA receptor "
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a000daf8fa3034bc9e871a9800803b
Autor:
Nandan Haloi, Shan Huang, Aaron N. Nichols, Eve J. Fine, Christopher B. Marotta, Dennis A. Dougherty, Erik Lindahl, Rebecca J. Howard, Stephen L. Mayo, Henry A. Lester
Publikováno v:
bioRxiv
To develop more sensitive fluorescent protein sensors for nicotine, we combined computational protein design, site-saturated, site-directed, and combinatorial mutagenesis with fluorescence assays, molecular dynamics simulations, and absorbance measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e006d2d998b11ecd045bc5d0daafcc24
https://doi.org/10.1101/2023.01.16.524298
https://doi.org/10.1101/2023.01.16.524298
Autor:
Emad Tajkhorshid, Arjun Prasanna, Emily J. Geddes, William W. Metcalf, Po-Chao Wen, Paul J. Hergenrother, Archit Kumar Vasan, Nandan Haloi
Publikováno v:
Chemical Science
Antibiotic resistance of Gram-negative bacteria is largely attributed to the low permeability of their outer membrane (OM). Recently, we disclosed the eNTRy rules, a key lesson of which is that the introduction of a primary amine enhances OM permeati
Autor:
Archit Kumar Vasan, Nandan Haloi, Rebecca Joy Ulrich, Mary Elizabeth Metcalf, Po-Chao Wen, William W. Metcalf, Paul J. Hergenrother, Diwakar Shukla, Emad Tajkhorshid
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(8)
Significance Antibiotic resistance in Gram-negative pathogens has been identified as an urgent threat to human health by the World Health Organization. The major challenge with treating infections by these pathogens is developing antibiotics that can
Autor:
Emad Tajkhorshid, Rebecca Joy Ulrich, Diwakar Shukla, Nandan Haloi, Archit Kumar Vasan, William W. Metcalf, Po-Chao Wen, Mary Elizabeth Metcalf, Paul J. Hergenrother
Gram-negative bacteria pose a serious public health concern, primarily due to a higher frequency of antibiotic resistance conferred to them as a result of low permeability of their outer membrane (OM). Antibiotics capable of traversing the OM typical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b70e604fb4f0e048f794c6af16ebca2
https://doi.org/10.1101/2021.09.09.459668
https://doi.org/10.1101/2021.09.09.459668
Autor:
Emily J. Geddes, Archit Kumar Vasan, Emad Tajkhorshid, Arjun Prasanna, Nandan Haloi, Po-Chao Wen, William W. Metcalf, Paul J. Hergenrother
Antibiotic resistance of Gram-negative bacteria is largely attributed to the low permeability of their outer membrane (OM). Recently, we disclosed the eNTRy rules, a key lesson of which is that the introduction of a primary amine enhances OM permeati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15808720fdd36acecd33cf26245e4138
https://doi.org/10.1101/2021.08.10.455597
https://doi.org/10.1101/2021.08.10.455597