Zobrazeno 1 - 10
of 885
pro vyhledávání: '"Nandakumar S"'
Autor:
Md Fahim Anjum, Arturo I. Espinoza, Rachel C. Cole, Arun Singh, Patrick May, Ergun Y. Uc, Soura Dasgupta, Nandakumar S. Narayanan
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Cognitive dysfunction is common in Parkinson’s disease (PD). We developed and evaluated an EEG-based biomarker to index cognitive functions in PD from a few minutes of resting-state EEG. We hypothesized that synchronous changes in EEG acro
Externí odkaz:
https://doaj.org/article/0004fef7c4fc428493394c001755de42
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-4 (2023)
Abstract Black patients are diagnosed with Parkinson’s disease (PD) at half the rate as White patients. The reasons for this large disparity are unknown. Here, we review evidence that practitioner bias may contribute. A key sign of PD is hypomimia
Externí odkaz:
https://doaj.org/article/9230ee5dd48f4c988956625025d1910f
Publikováno v:
NeuroImage: Clinical, Vol 42, Iss , Pp 103610- (2024)
Parkinson’s disease (PD) is a neurodegenerative disease with cognitive as well as motor impairments. While much is known about the brain networks leading to motor impairments in PD, less is known about the brain networks contributing to cognitive i
Externí odkaz:
https://doaj.org/article/9092ee3203c04a5b969222488602901b
Autor:
Matthew A. Weber, Kartik Sivakumar, Ervina E. Tabakovic, Mayu Oya, Georgina M. Aldridge, Qiang Zhang, Jacob E. Simmering, Nandakumar S. Narayanan
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-7 (2023)
Abstract Terazosin is an α1-adrenergic receptor antagonist that enhances glycolysis and increases cellular ATP by binding to the enzyme phosphoglycerate kinase 1 (PGK1). Recent work has shown that terazosin is protective against motor dysfunction in
Externí odkaz:
https://doaj.org/article/38e462d1a6dc47ff8d31c8842bd10d04
Autor:
Yuhang Wang, Joyce Z. Gao, Taylor Sakaguchi, Thorsten Maretzky, Prajwal Gurung, Nandakumar S. Narayanan, Sarah Short, Yiqin Xiong, Zizhen Kang
Publikováno v:
Cells, Vol 13, Iss 7, p 565 (2024)
Leucine-rich repeat kinase 2 (LRRK2) is a serine–threonine protein kinase belonging to the ROCO protein family. Within the kinase domain of LRRK2, a point mutation known as LRRK2 G2019S has emerged as the most prevalent variant associated with Park
Externí odkaz:
https://doaj.org/article/472c130cec2241ce8e3466d3b27577cb
Autor:
Youngcho Kim, Dennis Jung, Mayu Oya, Morgan Kennedy, Tomas Lence, Stephanie L. Alberico, Nandakumar S. Narayanan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Brain rhythms are strongly linked with behavior, and abnormal rhythms can signify pathophysiology. For instance, the basal ganglia exhibit a wide range of low-frequency oscillations during movement, but pathological “beta” rhythms at ~ 2
Externí odkaz:
https://doaj.org/article/894efdba1bef4130976cf5d924c27e06
Autor:
Arun Singh, Rachel C. Cole, Arturo I. Espinoza, Aron Evans, Scarlett Cao, James F. Cavanagh, Nandakumar S. Narayanan
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract Patients with Parkinson’s disease (PD) can have significant cognitive dysfunction; however, the mechanisms for these cognitive symptoms are unknown. Here, we used scalp electroencephalography (EEG) to investigate the cortical basis for PD-
Externí odkaz:
https://doaj.org/article/8bed2399f3924f909f1dfe1750bc593f
Autor:
Annette Klomp, Ryotaro Omichi, Yoichiro Iwasa, Richard J Smith, Yuriy M Usachev, Andrew F Russo, Nandakumar S Narayanan, Amy Lee
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0263197 (2022)
Voltage-gated Ca2+ channels are critical for the development and mature function of the nervous system. Variants in the CACNA2D4 gene encoding the α2δ-4 auxiliary subunit of these channels are associated with neuropsychiatric and neurodevelopmental
Externí odkaz:
https://doaj.org/article/d476844d6e3843fda04f62530a857a90
Autor:
Arturo I. Espinoza, Patrick May, Md Fahim Anjum, Arun Singh, Rachel C. Cole, Nicholas Trapp, Soura Dasgupta, Nandakumar S. Narayanan
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 7, Iss , Pp 100166- (2022)
Introduction: Depression is a non-motor symptom of Parkinson’s disease (PD). PD-related depression is difficult to diagnose, and the neurophysiological basis is poorly understood. Depression can markedly affect cortical function, which suggests tha
Externí odkaz:
https://doaj.org/article/8866079b06cc45d89d7bb092a78e79ab
Autor:
GOVINDARAJ G, GANESH KUMAR B, KRISHNAMOHAN A, RAVEENDRA HEGDE, NANDAKUMAR S, KOKILA PRABHAKARAN, VINAY MOHAN, NARESH KAKKER, LOKHANDE T, KRISHNA SHARMA, AMIT KANANI, LIMAYE A, NATCHIMUTHU K, TANVEER AHMED KHAN, JYOTI MISRI, DASH B B, PATTNAIK B, RAHMAN H
Publikováno v:
Indian Journal of Animal Sciences, Vol 90, Iss 7 (2020)
In India, among various diseases that limit livestock production, Foot and Mouth Disease (FMD) stands first and affects thousands of animals every year. The estimation of loss due to FMD is of paramount importance for designing appropriate control pl
Externí odkaz:
https://doaj.org/article/e269dc094bcc4f47b766c19e4bc2ba59