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pro vyhledávání: '"Nanda Sinha"'
Autor:
Kaijiang Zhang, HaJeung Park, Nanda Sinha, ChulHee Kang, Yingjie Ren, Sourena Nadji, John-Stephen Taylor
Publikováno v:
Proceedings of the National Academy of Sciences. 99:15965-15970
It is well known that exposure to UV induces DNA damage, which is the first step in mutagenesis and a major cause of skin cancer. Among a variety of photoproducts, cyclobutane-type pyrimidine photodimers (CPD) are the most abundant primary lesion. De
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 52:465-468
A matrix screen is presented with optimized conditions for the crystallization of nucleic acid fragments. The screen consists of 24 conditions only and utilizes minimal amounts of sample. It has been tested on a series of DNA and RNA oligomers, and y