Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nanda K. Mandava"'
Publikováno v:
International Journal of Pharmaceutics. 476:99-107
Oral absorption of lopinavir (LPV) is limited due to P-glycoprotein (P-gp) and multidrug resistance-associated protein2 (MRP2) mediated efflux by intestinal epithelial cells. Moreover, LPV is extensively metabolized by CYP3A4 enzymes. In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad83179309f88264d0031adb0551142
https://doi.org/10.1016/j.ijpharm.2014.09.035
https://doi.org/10.1016/j.ijpharm.2014.09.035
Autor:
Dhananjay Pal, Nanda K. Mandava, Ravinder Earla, Deep Kwatra, Mukul Minocha, Ashim K. Mitra, William R. Folk
Publikováno v:
International Journal of Pharmaceutics. 413:44-50
Sutherlandia frutescens (sutherlandia), an African herbal supplement is currently recommended by the South African Ministry of Health for the treatment of AIDS patients. However, no reports yet exist delineating the effect of sutherlandia on pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2f638807a0df21c2c71f8d97b03578
https://doi.org/10.1016/j.ijpharm.2011.04.051
https://doi.org/10.1016/j.ijpharm.2011.04.051
Publikováno v:
Journal of Drug Delivery Science and Technology. 20:89-99
The pharmacological behavior of various drugs is severely affected by biological barriers such as epithelial tight junctions, efflux proteins and metabolizing enzymes. Apart from the biological barriers, physicochemical properties of drug molecules s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::639e5d6f5351e44483d20155831549b6
https://doi.org/10.1016/s1773-2247(10)50012-1
https://doi.org/10.1016/s1773-2247(10)50012-1
Publikováno v:
Molecular Pharmaceutics. 3:329-339
The objective of this research is to characterize a sodium-dependent multivitamin transporter (SMVT) in MDCK-MDR1 cells (Madin-Darby canine kidney cells transfected with the human MDR1 gene) and to investigate the feasibility of utilizing the MDCK-MD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627ecba0b9098a979e3df1a63b62f87f
https://doi.org/10.1021/mp0500768
https://doi.org/10.1021/mp0500768
Publikováno v:
Pharmaceuticals
Pharmaceuticals; Volume 7; Issue 4; Pages: 433-452
Pharmaceuticals, Vol 7, Iss 4, Pp 433-452 (2014)
Pharmaceuticals; Volume 7; Issue 4; Pages: 433-452
Pharmaceuticals, Vol 7, Iss 4, Pp 433-452 (2014)
Poor systemic concentrations of lopinavir (LPV) following oral administration occur due to high cellular efflux by P-glycoprotein (P-gp) and multidrug resistance-associated proteins (MRPs) and extensive metabolism by CYP3A4 enzymes. In this study, am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab7392534073512ab9e7272f5d33569
https://pubmed.ncbi.nlm.nih.gov/24727459
https://pubmed.ncbi.nlm.nih.gov/24727459
Publikováno v:
International journal of pharmaceutics. 464(1-2)
In the present study, we investigated the effect of large neutral amino acid modification in overcoming P-gp mediated cellular efflux of quinidine. L-isoleucine ester prodrug of quinidine (Ile-quinidine) was synthesized in our laboratory. [14C]-eryth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5216d49d9188f74ae8c1127d5a4c8c6
https://pubmed.ncbi.nlm.nih.gov/24440401
https://pubmed.ncbi.nlm.nih.gov/24440401
Publikováno v:
Ocular Transporters In Ophthalmic Diseases And Drug Delivery ISBN: 9781588299581
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::284dcb2e65256fab20936de7fd3050cc
https://doi.org/10.1007/978-1-59745-375-2_21
https://doi.org/10.1007/978-1-59745-375-2_21
Publikováno v:
International journal of pharmaceutics. 362(1-2)
Saquinavir (SQV), the first protease inhibitor approved by FDA to treat HIV-1 infection. This drug is a well-known substrate for multidrug resistance protein-2 (MRP-2). The objective of this study was to investigate whether derivatization of SQV to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e707ff4b6a2964e933ba4cd81166e86
https://pubmed.ncbi.nlm.nih.gov/18620036
https://pubmed.ncbi.nlm.nih.gov/18620036
Saquinavir (SQV) was the first human immuno-virus-1 (HIV-1) protease inhibitor approved by FDA. However, P-glycoprotein (P-gp), an efflux pump limits its oral and brain bioavailabilities. The objective of this study is to investigate whether prodrug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04141d208f575c1fe50c6400daff8bd6
https://europepmc.org/articles/PMC3166959/
https://europepmc.org/articles/PMC3166959/