Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Nanda Gruben"'
1
Akademický článek
Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies
Autor: Stephanie Vauleon, Katharina Schutz, Benoit Massonnet, Nanda Gruben, Marianne Manchester, Alessandra Buehler, Eginhard Schick, Lauren Boak, David J. Hawellek
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Huntington’s disease (HD) is caused by a cytosine adenine guanine-repeat expansion in the huntingtin gene. This results in the production of toxic mutant huntingtin protein (mHTT), which has an elongated polyglutamine (polyQ) stretch near
Externí odkaz: https://doaj.org/article/bad2f4a1d56e443989a5c40b6c57ac69
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2
Akademický článek
The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis
Autor: Andries Heida, Nanda Gruben, Leen Catrysse, Martijn Koehorst, Mirjam Koster, Niels J. Kloosterhuis, Albert Gerding, Rick Havinga, Vincent W. Bloks, Laura Bongiovanni, Justina C. Wolters, Theo van Dijk, Geert van Loo, Alain de Bruin, Folkert Kuipers, Debby P.Y. Koonen, Bart van de Sluis
Publikováno v: Molecular Metabolism, Vol 54, Iss , Pp 101349- (2021)
Objective: Obesity-related chronic inflammation plays an important role in the development of Metabolic Associated Fatty Liver Disease (MAFLD). Although the contribution of the pro-inflammatory NF-κB signaling pathway to the progression from simple
Externí odkaz: https://doaj.org/article/54c1ebb08d38492b9a76c2c3c92de6e6
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3
Akademický článek
Cholesterol-Induced Hepatic Inflammation Does Not Underlie the Predisposition to Insulin Resistance in Dyslipidemic Female LDL Receptor Knockout Mice
Autor: Nanda Gruben, Anouk Funke, Niels J. Kloosterhuis, Marijke Schreurs, Fareeba Sheedfar, Rick Havinga, Sander M. Houten, Ronit Shiri-Sverdlov, Bart van de Sluis, Jan Albert Kuivenhoven, Debby P. Y. Koonen, Marten H. Hofker
Publikováno v: Journal of Diabetes Research, Vol 2015 (2015)
Chronic inflammation is considered a causal risk factor predisposing to insulin resistance. However, evidence is accumulating that inflammation confined to the liver may not be causal to metabolic dysfunction. To investigate this, we assessed if hepa
Externí odkaz: https://doaj.org/article/eb6d73580da24c64afa4ba2453dc8082
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4
Akademický článek
Chemokine-like receptor 1 deficiency does not affect the development of insulin resistance and nonalcoholic fatty liver disease in mice.
Autor: Nanda Gruben, Marcela Aparicio Vergara, Niels J Kloosterhuis, Henk van der Molen, Stefan Stoelwinder, Sameh Youssef, Alain de Bruin, Dianne J Delsing, Jan Albert Kuivenhoven, Bart van de Sluis, Marten H Hofker, Debby P Y Koonen
Publikováno v: PLoS ONE, Vol 9, Iss 4, p e96345 (2014)
The adipokine chemerin and its receptor, chemokine-like receptor 1 (Cmklr1), are associated with insulin resistance and nonalcoholic fatty liver disease (NAFLD), which covers a broad spectrum of liver diseases, ranging from simple steatosis to nonalc
Externí odkaz: https://doaj.org/article/9382eecd5fa54b4abd033bb97d14caf7
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5
D01 Two independent validations of a mutant huntingtin protein (MHTT) assay to support the clinical development of mHTT-targeting therapies in HD
Autor: Scott Schobel, Lauren Boak, Nanda Gruben, Katharina Schutz, Stephanie Vauleon, Marianne Manchester, David J. Hawellek, Benoit Massonnet
Publikováno v: D: Wet biomarkers.
Background Huntington’s disease (HD) is caused by a CAG repeat expansion in the huntingtin gene, resulting in the production of toxic mutant huntingtin protein (mHTT). Quantification of mHTT in the cerebrospinal fluid (CSF) of patients with HD usin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb2024172727a436f3d55be361de7a64
https://doi.org/10.1136/jnnp-2021-ehdn.32
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6
Nonalcoholic fatty liver disease
Autor: Ronit Shiri-Sverdlov, Marten H. Hofker, Nanda Gruben, Debby P.Y. Koonen
Publikováno v: Biochimica et Biophysica Acta-Molecular Basis of Disease, 1842(11), 2329-2343. Elsevier Science
Insulin resistance is one of the key components of the metabolic syndrome and it eventually leads to the development of type 2 diabetes, making it one of the biggest medical problems of modern society. Nonalcoholic fatty liver disease (NAFLD) and non
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7f7e70d378d794dd2228d9636e17f8
https://doi.org/10.1016/j.bbadis.2014.08.004
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7
Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity
Autor: Froukje J. Verdam, Jingyuan Fu, Lude Franke, M. H. Hofker, Cisca Wijmenga, Nanda Gruben, Sander S. Rensen, W.A. Buurman, Ann Driessen, Marcel G. M. Wolfs, Ronit Shiri-Sverdlov, T.W. van Haeften, Debby P.Y. Koonen, Jan Greve, Ludger Scheja
Publikováno v: Nutrition & Diabetes
Nutrition & Diabetes, 5:e146. Nature Publishing Group
Nutrition & diabetes
Nutrition & Diabetes, 5:146. Nature Publishing Group
OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated disease, and in obesity adipokines are believed to be involved in the development of NAFLD. However, it is still not clear whether adipokines in the liver and/or adipose t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901ba75df316d664abb111e35e356a71
https://doi.org/10.1038/nutd.2014.43
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8
Cholesterol-Induced Hepatic Inflammation Does Not Underlie the Predisposition to Insulin Resistance in Dyslipidemic Female LDL Receptor Knockout Mice
Autor: Bart van de Sluis, Nanda Gruben, Marijke Schreurs, Rick Havinga, Marten H. Hofker, Anouk Funke, Ronit Shiri-Sverdlov, Fareeba Sheedfar, Jan Albert Kuivenhoven, Sander M. Houten, Debby P.Y. Koonen, Niels J. Kloosterhuis
Publikováno v: Journal of Diabetes Research, 2015:956854. Hindawi Publishing Corporation
Journal of Diabetes Research, Vol 2015 (2015)
Journal of Diabetes Research
Journal of Diabetes Research, 2015:956854. HINDAWI LTD
Journal of Diabetes Research, 2015, pp. 956854
Journal of diabetes research, 2015. Hindawi Publishing Corporation
Journal of Diabetes Research, 2015, 956854
Chronic inflammation is considered a causal risk factor predisposing to insulin resistance. However, evidence is accumulating that inflammation confined to the liver may not be causal to metabolic dysfunction. To investigate this, we assessed if hepa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f52e6d65f293dbe01016bdd0344981
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9
Nonalcoholic fatty liver disease: A main driver of insulin resistance or a dangerous liaison?
Autor: Nanda, Gruben, Ronit, Shiri-Sverdlov, Debby P Y, Koonen, Marten H, Hofker
Publikováno v: Biochimica et biophysica acta. 1842(11)
Insulin resistance is one of the key components of the metabolic syndrome and it eventually leads to the development of type 2 diabetes, making it one of the biggest medical problems of modern society. Nonalcoholic fatty liver disease (NAFLD) and non
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28fec018b106479f33fb099f5eeaff3c
https://pubmed.ncbi.nlm.nih.gov/25128743
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