A structural view onto disease-linked mutations in the human neutral amino acid exchanger ASCT1

Autor: Pavlo Stehantsev, Artem Stetsenko, Mariia Nemchinova, Nanda Gowtham Aduri, Siewert J. Marrink, Cornelius Gati, Albert Guskov

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5246-5254 (2021)

The ASCT1 transporter of the SLC1 family is largely involved in equilibration of neutral amino acids’ pools across the plasma membrane and plays a prominent role in the transport of both L- and D-isomers of serine, essential for the normal function

Externí odkaz: https://doaj.org/article/759c1ae3170943f9a860bc4d543b7f8a

Structural basis of GABA reuptake inhibition

Autor: Zenia Motiwala, Nanda Gowtham Aduri, Hamidreza Shaye, Gye Won Han, Jordy Homing Lam, Vsevolod Katritch, Vadim Cherezov, Cornelius Gati

Publikováno v: Nature

γ-Aminobutyric acid (GABA) transporter 1 (GAT1)(1) regulates neuronal excitation of the central nervous system by clearing the synaptic cleft of the inhibitory neurotransmitter GABA upon its release from synaptic vesicles. Elevating the levels of GA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0af927a6b97da62ddc101d07ec030b
https://doi.org/10.1038/s41586-022-04814-x

Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state

Autor: Nanda Gowtham Aduri, Thomas Boesen, Bala Krishna Prabhala, Heidi Asschenfeldt Ernst, Osman Asghar Mirza, Shweta Bhatt, Michael Gajhede, Olivia Mirza

Publikováno v: Aduri, N G, Ernst, H A, Prabhala, B K, Bhatt, S, Boesen, T, Gajhede, M & Mirza, O 2018, ' Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state ', Biochemical and Biophysical Research Communications, vol. 495, no. 2, pp. 1738-1743 . https://doi.org/10.1016/j.bbrc.2017.12.008

The human proton coupled folic acid transporter PCFT is the major import route for dietary folates. Mutations in the gene encoding PCFT cause hereditary folic acid malabsorption, which manifests itself by compromised folate absorption from the intest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b08670c36690b25628433f95d06163
https://doi.org/10.1016/j.bbrc.2017.12.008