Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nanda Boon"'
Autor:
Lisa Maria Riedmayr, Klara Sonnie Hinrichsmeyer, Stefan Bernhard Thalhammer, David Manuel Mittas, Nina Karguth, Dina Yehia Otify, Sybille Böhm, Valentin Johannes Weber, Michael David Bartoschek, Victoria Splith, Manuela Brümmer, Raphael Ferreira, Nanda Boon, Gabriele Maria Wögenstein, Christian Grimm, Jan Wijnholds, Verena Mehlfeld, Stylianos Michalakis, Stefanie Fenske, Martin Biel, Elvir Becirovic
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Large genes including several CRISPR-Cas modules like gene activators (CRISPRa) require dual adeno-associated viral (AAV) vectors for an efficient in vivo delivery and expression. Current dual AAV vector approaches have important limitations
Externí odkaz:
https://doaj.org/article/ed8130e2a4b84e5eb1442fbb00645d85
Autor:
Nanda Boon, Xuefei Lu, Charlotte A. Andriessen, Michaela Orlovà, Peter M.J. Quinn, Camiel J.F. Boon, Jan Wijnholds
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101128- (2023)
The majority of patients with mutations in CRB1 develop either early-onset retinitis pigmentosa as young children or Leber congenital amaurosis as newborns. The cause for the phenotypic variability in CRB1-associated retinopathies is unknown, but mig
Externí odkaz:
https://doaj.org/article/7d6272b4590f480aa0bc901974a01e0e
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA) are inherited degenerative retinal dystrophies with vision loss that ultimately lead to blindness. Several genes have been shown to be involved in early onset retinal dystrophies, includi
Externí odkaz:
https://doaj.org/article/38559024d6d840d38e317a4f6c5e9aef
Autor:
Nanda Boon, C. Henrique Alves, Aat A. Mulder, Charlotte A. Andriessen, Thilo M. Buck, Peter M. J. Quinn, Rogier M. Vos, Abraham J. Koster, Carolina R. Jost, Jan Wijnholds
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3563 (2021)
Mutations in the Crumbs homologue 1 (CRB1) gene cause inherited retinal dystrophies, such as early-onset retinitis pigmentosa and Leber congenital amaurosis. A Brown Norway rat strain was reported with a spontaneous insertion-deletion (indel) mutatio
Externí odkaz:
https://doaj.org/article/19cb45c2cd354af3848af7cf84caed6e
Autor:
C. Henrique Alves, Nanda Boon, Aat A. Mulder, Abraham J. Koster, Carolina R. Jost, Jan Wijnholds
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4069 (2019)
Variations in the Crumbs homolog-1 (CRB1) gene are associated with a wide variety of autosomal recessive retinal dystrophies, including early onset retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA). CRB1 belongs to the Crumbs family, whi
Externí odkaz:
https://doaj.org/article/d436a78b1b844b1885001827a7d652a9
Autor:
Nanda Boon, Xuefei Lu, Charlotte A. Andriessen, Ioannis Moustakas, Thilo M. Buck, Christian Freund, Christiaan H. Arendzen, Stefan Böhringer, Camiel J.F. Boon, Hailiang Mei, Jan Wijnholds
Publikováno v:
Stem Cell Reports, 18, 1123-1137. Cell Press
Retinitis pigmentosa and Leber congenital amaurosis are inherited retinal dystrophies that can be caused by mutations in the Crumbs homolog 1 (CRB1) gene. CRB1 is required for organizing apical-basal polarity and adhesion between photoreceptors and M
Autor:
Veerle Van Marck, Juan E. Rodriguez-Gatica, Nanda Boon, Jan Wijnholds, Rohan Bhatia, Karin Wacker, Peter Boor, Annika Möller-Kerutt, Jan Peter Siebrasse, Hermann Pavenstädt, Thomas Weide, Ulrich Kubitscheck
Publikováno v:
Journal of the American Society of Nephrology, 32(5), 1053-1070. AMER SOC NEPHROLOGY
J Am Soc Nephrol
Journal of the American Society of Nephrology : JASN, 32, 1053-1070. American Society of Nephrology
J Am Soc Nephrol
Journal of the American Society of Nephrology : JASN, 32, 1053-1070. American Society of Nephrology
BACKGROUND: Crumbs2 is expressed at embryonic stages as well as in the retina, brain, and glomerular podocytes. Recent studies identified CRB2 mutations as a novel cause of steroid-resistant nephrotic syndrome (SRNS). METHODS: To study the function o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023702e8491af03f138756b5f9907032
http://hdl.handle.net/1887/3276518
http://hdl.handle.net/1887/3276518
Autor:
Lambertus A. Kiemeney, J. Alfred Witjes, Nanda Boon, Aleksandra M. Dudek, Sabrina Boer, Gerald W. Verhaegh
Publikováno v:
Oncotarget
Oncotarget, 8, 21, pp. 34442-34452
Oncotarget, 8, 34442-34452
Oncotarget, 8, 21, pp. 34442-34452
Oncotarget, 8, 34442-34452
Contains fulltext : 174142.pdf (Publisher’s version ) (Open Access) For many years, research on the biology underlying bladder cancer focused on protein-coding genes which cover only about 3% of the human genome. Recently, it was discovered that a
Autor:
Nanda Boon, Carolina R. Jost, Jan Wijnholds, Abraham J. Koster, Aat A. Mulder, C. Henrique Alves
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 17
International Journal of Molecular Sciences, 20(17). Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 20(17). MDPI
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4069 (2019)
Volume 20
Issue 17
International Journal of Molecular Sciences, 20(17). Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 20(17). MDPI
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4069 (2019)
Variations in the Crumbs homolog-1 (CRB1) gene are associated with a wide variety of autosomal recessive retinal dystrophies, including early onset retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA). CRB1 belongs to the Crumbs family, whi
Autor:
Aat A. Mulder, Carolina R. Jost, Abraham J. Koster, Charlotte A Andriessen, Peter M Quinn, Thilo M. Buck, Jan Wijnholds, C. Henrique Alves, Rogier M. Vos, Nanda Boon
Publikováno v:
International Journal of Molecular Sciences, 22(7):3563. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 22(7). MDPI
International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3563, p 3563 (2021)
International Journal of Molecular Sciences, 22(7). MDPI
International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3563, p 3563 (2021)
Mutations in the Crumbs homologue 1 (CRB1) gene cause inherited retinal dystrophies, such as early-onset retinitis pigmentosa and Leber congenital amaurosis. A Brown Norway rat strain was reported with a spontaneous insertion-deletion (indel) mutatio