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Akademický článek

Safety, Pharmacokinetics, and Pharmacodynamics of ASP3662, a Novel 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitor, in Healthy Young and Elderly Subjects

Autor: Susan Bellaire, Mark Walzer, Tianli Wang, Walter Krauwinkel, Nancy Yuan, Gerard J. Marek

Publikováno v: Clinical and Translational Science, Vol 12, Iss 3, Pp 291-301 (2019)

Inhibition of the enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) represents a potential mechanism for improving pain conditions. ASP3662 is a potent and selective inhibitor of 11β‐HSD1. Two phase I clinical studies were conducted

Externí odkaz: https://doaj.org/article/4136bf49b098469fa7b9596299aa65f8

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Inhibition of Complement Factor 3 in Geographic Atrophy with NGM621: Phase 1 Dose-Escalation Study Results

Autor: Priya Chandra, Husam Younis, Charles C. Wykoff, Erin C. Henry, David A Eichenbaum, Alex DePaoli, Mark Solloway, Vrinda S. Hershberger, Nancy Yuan

Publikováno v: American Journal of Ophthalmology. 235:131-142

Purpose To evaluate the safety and tolerability of single and multiple intravitreal injections of NGM621 in patients with geographic atrophy (GA) and to characterize the pharmacokinetics and immunogenic potential. Design Multicenter, open-label, sing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04cf0473865e86e63c4f2aef0b93bcb
https://doi.org/10.1016/j.ajo.2021.08.018

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CNN-based Deformable Registration Facilitates Fast and Accurate Air Trapping Measurements at Inspiratory and Expiratory CT

Autor: Kyle Hasenstab, Nancy Yuan, Joseph Tabalon, Tara Retson, Albert Hsiao

Publikováno v: Radiol Artif Intell
Radiology. Artificial intelligence, vol 4, iss 1

PurposeTo develop a convolutional neural network (CNN)-based deformable lung registration algorithm to reduce computation time and assess its potential for lobar air trapping quantification.Materials and methodsIn this retrospective study, a CNN algo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135b846a469fbcda8e58c48f16bdab81
https://pubmed.ncbi.nlm.nih.gov/35157746

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Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain

Autor: Teresa Lara-Jaime, Beata Planeta, David Matuskey, Richard E. Carson, Jim Ropchan, Anupama Shirali, Shannan Henry, Yiyun Huang, Susan Bellaire, Michael Kapinos, David Labaree, Jean-Dominique Gallezot, Mark Walzer, Richard Pracitto, Nabeel Nabulsi, Gerard J. Marek, Hong Gao, Shu-fei Lin, Nancy Yuan

Publikováno v: Journal of Nuclear Medicine. 60:1140-1146

The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts cortisone to cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is expressed in the liver, kidney, adipose tissue, placenta, and brain. 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08a4febdb7cf656fc48bfc735235eca6
https://doi.org/10.2967/jnumed.118.219766

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Safety, Pharmacokinetics, and Pharmacodynamics of ASP3662, a Novel 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitor, in Healthy Young and Elderly Subjects

Autor: Nancy Yuan, Gerard J. Marek, Mark Walzer, Walter Krauwinkel, Susan Bellaire, Tianli Wang

Publikováno v: Clinical and Translational Science
Clinical and Translational Science, Vol 12, Iss 3, Pp 291-301 (2019)

Inhibition of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) represents a potential mechanism for improving pain conditions. ASP3662 is a potent and selective inhibitor of 11β-HSD1. Two phase I clinical studies were conducted to ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ebcebc04b12675c08b2d8dbf992e39
http://europepmc.org/articles/PMC6510378

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Automated CT Staging of Chronic Obstructive Pulmonary Disease Severity for Predicting Disease Progression and Mortality with a Deep Learning Convolutional Neural Network

Autor: David A. Lynch, Albert Hsiao, Nancy Yuan, Kyle Hasenstab, Seth Kligerman, Tara Retson, Douglas Conrad

Publikováno v: Radiol Cardiothorac Imaging

PURPOSE: To develop a deep learning–based algorithm to stage the severity of chronic obstructive pulmonary disease (COPD) through quantification of emphysema and air trapping on CT images and to assess the ability of the proposed stages to prognost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94720fdfecccfd8d63ee819d25ba99f
https://pubmed.ncbi.nlm.nih.gov/35782763

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Study EV-103: Durability results of enfortumab vedotin plus pembrolizumab for locally advanced or metastatic urothelial carcinoma

Autor: Daniel P. Petrylak, Jaime R. Merchan, Nancy Yuan, Mehmet Asim Bilen, Thomas W. Flaig, Christopher J. Hoimes, Anne-Sophie Carret, Matthew I. Milowsky, Sandy Srinivas, Jonathan E. Rosenberg, Terence W. Friedlander, Carolyn Sasse

Publikováno v: Journal of Clinical Oncology. 38:5044-5044

5044 Background: Platinum chemotherapy is the standard for patients (pts) with metastatic urothelial carcinoma (mUC) in the first line (1L) setting. PD-1/PD-L1 inhibitors, such as pembrolizumab (P), have shown promising durability in this setting for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf1df9de5a0c5571f7f8b475a30e446c
https://doi.org/10.1200/jco.2020.38.15_suppl.5044

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Study EV-103: Preliminary durability results of enfortumab vedotin plus pembrolizumab for locally advanced or metastatic urothelial carcinoma

Autor: Nancy Yuan, Mehmet Asim Bilen, Thomas W. Flaig, Jaime R. Merchan, Jonathan E. Rosenberg, Matthew I. Milowsky, Terence W. Friedlander, Christopher J. Hoimes, Carolyn Sasse, Sandy Srinivas, Daniel P. Petrylak, Anne-Sophie Carret

Publikováno v: Journal of Clinical Oncology. 38:441-441

441 Background: Platinum chemotherapy is the standard for patients (pts) with metastatic urothelial carcinoma (mUC) in the first line (1L) setting. In cisplatin-ineligible pts, gem/carbo is a standard therapy, but is poorly tolerated with limited dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b488b67ccd8ca8b0a345f786bbff0979
https://doi.org/10.1200/jco.2020.38.6_suppl.441

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Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer

Autor: Jean-Dominique, Gallezot, Nabeel, Nabulsi, Shannan, Henry, Richard, Pracitto, Beata, Planeta, Jim, Ropchan, Shu-Fei, Lin, David, Labaree, Michael, Kapinos, Anupama, Shirali, Teresa, Lara-Jaime, Hong, Gao, David, Matuskey, Mark, Walzer, Gerard J, Marek, Susan, Bellaire, Nancy, Yuan, Richard E, Carson, Yiyun, Huang

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65fc84577b5b981373e8407d67f91100
https://pubmed.ncbi.nlm.nih.gov/30877174

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