Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nancy Wakeham"'
Autor:
Richard A. Bunce, William W. Barrow, Christina R. Bourne, Esther W. Barrow, K. Darrell Berlin, Baskar Nammalwar, Nancy Wakeham, Philip C. Bourne, N. Prasad Muddala
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:203-211
The current Letter describes the synthesis and biological evaluation of dihydrophthalazine-appended 2,4-diaminopyrimidine (DAP) inhibitors (1) oxidized at the methylene bridge linking the DAP ring to the central aromatic ring and (2) modified at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19aced645063058597583e67dfe40026
https://doi.org/10.1016/j.bmc.2014.11.009
https://doi.org/10.1016/j.bmc.2014.11.009
Autor:
Nicole Webb, William W. Barrow, Nancy Wakeham, Christina R. Bourne, K. Darrell Berlin, Baskar Nammalwar, Richard A. Bunce
Publikováno v:
Biochemistry
We are addressing bacterial resistance to antibiotics by repurposing a well-established classic antimicrobial target, the dihydrofolate reductase (DHFR) enzyme. In this work, we have focused on Enterococcus faecalis, a nosocomial pathogen that freque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6b872f260f06c9e800efb33b8e0699
http://europepmc.org/articles/PMC3985486
http://europepmc.org/articles/PMC3985486
Autor:
K. Darrell Berlin, Richard A. Bunce, Baskar Nammalwar, William W. Barrow, Shankari Mylvaganam, Philip C. Bourne, Christina R. Bourne, Esther W. Barrow, Nancy Wakeham, Kal Ramnarayan
Publikováno v:
ChemMedChem. 7:1974-1982
A series of (±)-6-alkyl-2,4-diaminopyrimidine-based inhibitors of bacterial dihydrofolate reductase (DHFR) have been prepared and evaluated for biological potency against Bacillus anthracis and Staphylococcus aureus. Biological studies reveal attenu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f81fbb16ff5a056bd7eb4a97886538
https://doi.org/10.1002/cmdc.201200291
https://doi.org/10.1002/cmdc.201200291
Autor:
Nancy Wakeham, Christina R. Bourne, Baskar Nammalwar, Richard A. Bunce, William W. Barrow, K. Darrell Berlin
Publikováno v:
Journal of Molecular Recognition. 25:216-223
Drug development programs have proven successful when performed at a whole cell level, thus incorporating solubility and permeability into the primary screen. However, linking those results to the target within the cell has been a major setback. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09988725627b5906185849d29fa91252
https://doi.org/10.1002/jmr.2174
https://doi.org/10.1002/jmr.2174
Autor:
Guangyu Zhu, Guangpu Li, Joseph S. Brunzelle, Bo Huang, Simon Terzyan, Jay Liu, Zihe Rao, Jia Chen, Xuemei Li, Nancy Wakeham, Xuejun C. Zhang
Publikováno v:
The EMBO Journal
APPL1 is an effector of the small GTPase Rab5. Together, they mediate a signal transduction pathway initiated by ligand binding to cell surface receptors. Interaction with Rab5 is confined to the amino (N)-terminal region of APPL1. We report the crys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3e4c165ce81643ca21e5433350d43b
http://europepmc.org/articles/PMC1933402
http://europepmc.org/articles/PMC1933402
Autor:
Guangyu Zhu, Nancy Wakeham, Xuejun C. Zhang, Karla K. Rodgers, Peng Zhai, Guangpu Li, Xiangyuan He, Jordan Tang
Publikováno v:
The EMBO Journal. 23:3909-3917
GGA proteins coordinate the intracellular trafficking of clathrin-coated vesicles through their interaction with several other proteins. The GAT domain of GGA proteins interacts with ARF, ubiquitin, and Rabaptin5. The GGA-Rabaptin5 interaction is bel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d41c263668ddd9d4b3f6d35502381ed
https://doi.org/10.1038/sj.emboj.7600411
https://doi.org/10.1038/sj.emboj.7600411
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 56:277-284
Streptokinase (SK) is a human plasminogen (Pg) activator secreted by streptococci. The activation mechanism of SK differs from that of physiological Pg activators in that SK is not a protease and cannot proteolytically activate Pg. Instead, it forms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1271c2db6ee23d155780e5e3c1ab0a3
https://doi.org/10.1002/prot.20070
https://doi.org/10.1002/prot.20070
Autor:
Xuejun C. Zhang, Guangyu Zhu, Jian Liu, Guangpu Li, Nancy Wakeham, Xiangyuan He, Jordan Tang, Peng Zhai
Publikováno v:
Biochemistry. 42:13901-13908
GGA proteins regulate clathrin-coated vesicle trafficking by interacting with multiple proteins during vesicle assembly. As part of this process, the GAT domain of GGA is known to interact with both ARF and Rabaptin-5. Particularly, the GAT domains o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ed84064095cbe4f4a189ed1f0278b7
https://doi.org/10.1021/bi035392b
https://doi.org/10.1021/bi035392b
Autor:
Nancy Wakeham, Celeste R. Wirsig-Wiechmann, Marie H. Hanigan, Elizabeth M. Gillies, Stephanie Wickham
Publikováno v:
Histochemistry and cell biology. 143(5)
Gamma-glutamyl transferase (GGT5) was discovered due to its ability to convert leukotriene C4 (LTC4, a glutathione S-conjugate) to LTD4 and may have an important role in the immune system. However, it was not known which cells express the enzyme in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cf8682be6349d6ba1784908c307f41
https://pubmed.ncbi.nlm.nih.gov/25377544
https://pubmed.ncbi.nlm.nih.gov/25377544
Autor:
Christina R. Bourne, Esther W. Barrow, Vladimir Tseitin, Kal Ramnarayan, K. Darrell Berlin, William W. Barrow, Philip C. Bourne, Richard A. Bunce, Nancy Wakeham, Baskar Nammalwar, Shankari Mylvaganam
Background: Bacterial resistance to antibiotic therapies is increasing and new treatment options are badly needed. There is an overlap between these resistant bacteria and organisms classified as likely bioterror weapons. For example, Bacillus anthra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4365355cfa9cfeee643025baf14bbf
https://europepmc.org/articles/PMC3530638/
https://europepmc.org/articles/PMC3530638/
