Pharmacokinetics and Pharmacodynamics of (S)-Ketoprofen Co-Administered with Caffeine: A Preclinical Study in Arthritic Rats

Autor: Raúl Medina-López, Nancy Vara-Gama, Olivia Soria-Arteche, Luis A. Moreno-Rocha, Francisco J. López-Muñoz

Publikováno v: Pharmaceutics, Vol 10, Iss 1, p 20 (2018)

The purpose of the present study was to determine whether caffeine modifies the pharmacokinetics and pharmacodynamics of (S)-ketoprofen following oral administration in a gout-type pain model. 3.2 mg/kg of (S)-ketoprofen alone and combined with 17.8

Externí odkaz: https://doaj.org/article/7afdc19064734b89a24e3ee88cf24f51

Physicochemical and Biopharmaceutical Evaluation of Casiopeina III-Ea, a New Compound with Antineoplastic Activity

Autor: Lena Ruiz-Azuara, Nancy Vara-Gama, Adrián Espinoza-Guillén, Kenneth Rubio-Carrasco, Inés Fuentes Noriega

Publikováno v: Journal of the Mexican Chemical Society. 65

In the present work, the physicochemical (pka, intrinsic solubility, Log D distribution coefficient) and biopharmaceutical characterization (IC50 studies in MDCK cells) of Casiopeina III-Ea, a Cu (II) mixed chelate compound, was carried out. These pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe54eb6334c97e24dccf4538d721f7b1
https://doi.org/10.29356/jmcs.v65i3.1471

Biopharmaceutical Characterization and Bioavailability Study of a Tetrazole Analog of Clofibric Acid in Rat

Autor: Luis Manuel Orozco-Castellanos, Samuel Estrada-Soto, Nancy Vara-Gama, Julio Cesar Rivera-Leyva, Gabriel Navarrete-Vázquez, Adriana Valladares-Méndez

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 22; Issue 2; Pages: 282
Molecules, Vol 22, Iss 2, p 282 (2017)

In the current investigation, the physicochemical, biopharmaceutical and pharmacokinetic characterization of a new clofibric acid analog (Compound 1) was evaluated. Compound 1 showed affinity by lipophilic phase in 1 to 5 pH interval, indicating that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9819bdd6c7cd019aba0cee755ac43c4
http://europepmc.org/articles/PMC6155746

HPLC method with solid-phase extraction for determination of (R)- and (S)-ketoprofen in plasma without caffeine interference: application to pharmacokinetic studies in rats

Autor: Adriana Miriam Domínguez-Ramírez, Francisco Javier López-Muñoz, Marcela Hurtado y de la Peña, José Raúl Medina López, Nancy Vara Gama, Olivia Soria-Arteche

Publikováno v: Journal of chromatographic science. 52(10)

A fast and reproducible high-performance liquid chromatography method has been developed for the determination of (R)- and (S)-ketoprofen. Ketoprofen enantiomers were determined in plasma samples (50 µL), after solid-phase extraction, using diclofen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2692c40441cf399b6b1a7fe7b4972e
https://pubmed.ncbi.nlm.nih.gov/24368338