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pro vyhledávání: '"Nancy Tryder"'
Autor:
Teresa Aja, Giovanni Roxas, Nancy Tryder, Carlos F. Barbas, Curt Bradshaw, Mysore P. Ramprasad, Francesca Fang Liao, Lingna Li, David A. Griffith, Venkata Doppalapudi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:501-506
Aryl sulfonamide-based endothelin antagonists were synthesized and covalently linked to the reactive lysine of the m38C2 antibody to create a series of CovX-Bodies. These chemically programmed antibodies behaved as potent endothelin receptor antagoni
Publikováno v:
The Journal of organic chemistry. 71(21)
A zinc-mediated chain extension reaction is the key step in the preparation of gamma-keto amides derived from amino acids. The use of tandem reaction sequences, in which the intermediate zinc enolate is trapped with electrophilic reagents, results in