Výsledky vyhledávání - "Nancy Sue Barta"

Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists

Autor: Susan Boroski, David Gray, Lynne Denny, Wenjian Xu, Brian M. Campbell, Nancy C. Stratman, Al Probert, Amy B. Dounay, Lori M. Evans, Nancy Sue Barta

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:6604-6607

Compounds that are both norepinephrine reuptake inhibitors (NRI) and 5-HT1(A) partial agonists may have the potential to treat neuropsychiatric disorders including attention deficit hyperactivity disorder (ADHD) and depression. Targeted screening of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7916137f2f69d7476e66bb4543f9d3d6
https://doi.org/10.1016/j.bmcl.2009.10.014

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Carboxylate bioisosteres of pregabalin

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:3559-3563

Several beta-amino tetrazole analogs of gabapentin 1 and pregabalin 2 were prepared by one of two convergent, highly efficient routes, and their affinity for the alpha(2)-delta protein examined. Two select compounds with potent affinity for alpha(2)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71639ec10a452e24f369e2dc36c1c1f
https://doi.org/10.1016/j.bmcl.2006.03.083

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Design, Synthesis, and Biological Activity of Novel Polycyclic Aza-Amide FKBP12 Ligands

Autor: Dong Liming, Xinjun Hou, Elizabeth A. Lunney, Corinne E. Augelli-Szafran, Deal Judith G, Christopher F. Bigge, Darin Vanderpool, Raymond Andrew Hudack, Nancy Sue Barta, Bradley William Caprathe, Chuangxing Guo, Steve Bender, Richard E. Showalter, Lorraine Kathleen Fay, Arindam Chatterjee

Publikováno v: Journal of Medicinal Chemistry. 49:1202-1206

Since the discovery that FK-506 promotes neurite outgrowth, considerable attention has been focused on the development of potent nonimmunosuppressive ligands for FK-506 binding proteins (FKBPs). Such neuroimmunophilin agents have been reported to sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fb4d75bb6365379c9f5766e6a1b084
https://doi.org/10.1021/jm049161u

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Practical Modifications and Applications of the Sharpless Asymmetric Aminohydroxylation in the One-Pot Preparation of Chiral Oxazolidin-2-ones

Autor: Nancy Sue Barta, Steven A. Weissman, Paul J. Reider, Kara B. Somerville, Daniel R. Sidler, Robert D. Larsen

Publikováno v: Organic Letters. 2:2821-2824

[reaction: see text] Chiral oxazolidin-2-ones are synthetically valuable as chiral auxiliaries, and many have pharmaceutically interesting biological activity. This communication focuses on a convenient, practical one-pot preparation of chiral 4,5-di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2391165dbffb5305d4e5339326bd8a
https://doi.org/10.1021/ol006255z

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Oligonucleotide Tagging for Copper-Free Click Conjugation

Autor: Alan E. Rowan, Jorge M. M. Verkade, Nancy Sue Barta, Sudip Malik, Brian Gibson, Floris L. van Delft, John Cooke Hodges, Anup M. Jawalekar

Publikováno v: Molecules, 18, 7, pp. 7346-7363
Molecules
Molecules, 18, 7346-7363
Molecules, Vol 18, Iss 7, Pp 7346-7363 (2013)
Volume 18
Issue 7
Pages: 7346-7363

Copper-free click chemistry between cyclooctynes and azide is a mild, fast and selective technology for conjugation of oligonucleotides. However, technology for site-specific introduction of the requisite probes by automated protocols is scarce, whil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796d0d9c31bb7860cc9ebadcb7a14afd
https://hdl.handle.net/2066/117135

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Mechanism-based pharmacokinetic/pharmacodynamic modeling of rat prefrontal cortical dopamine response to dual acting norepinephrine reuptake inhibitor and 5-HT1A partial agonist

Autor: Joanne Brodfuehrer, Cheryl Li, Christopher Lepsy, Amy B. Dounay, Brian M. Campbell, Nancy Sue Barta, David Gray, Liming Zhang, Taraneh Haske

Publikováno v: The AAPS journal. 14(2)

Evidence suggests that compounds possessing both norepinephrine reuptake inhibition and 5-HT1A partial agonism (NRI/5-HT1A) activities may have a greater efficacy in treating neuropsychiatric disorders than compounds possessing either activity alone.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25860bcda3ab718143201804dc9e8314
https://pubmed.ncbi.nlm.nih.gov/22454087

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Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists

Autor: Elizabeth M. Collantes, Kim Zoski, David Gray, Tammy Whisman, Nancy Sue Barta, Samarendra N. Maiti, Rajendra Subedi, Daniel F. Ortwine, Rathna Iyer, Lynne Denny, Satavisha Dutta, Al Probert, Corey Coleman, Nancy C. Stratman, Amy B. Dounay, Wenjian Xu, Brian M. Campbell, Dongfeng Hou

Publikováno v: Bioorganicmedicinal chemistry letters. 20(3)

Preclinical studies suggest that compounds with dual norepinephrine reuptake inhibitor (NRI) and 5-HT 1A partial agonist properties may provide an important new therapeutic approach to ADHD, depression, and anxiety. Reported herein is the discovery o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bda17a670e3dd8c3c539ca5fb025dd
https://pubmed.ncbi.nlm.nih.gov/20031410

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Synthesis and pharmacological evaluation of aminopyrimidine series of 5-HT1A partial agonists

Autor: Brian M. Campbell, Amy B. Dounay, Pil H. Lee, Nancy Sue Barta, Lori M. Evans, Terry Crawford, Susan A. Borosky, Wenjian Xu, David Gray, Lynne Denny, Jack A. Bikker, Edward A. Lenoir

Publikováno v: Bioorganicmedicinal chemistry letters. 19(4)

Aminopyrimidine 2 (4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-cyclopropylpyrimidin-2-amine) emerged from a high throughput screen as a novel 5-HT(1A) agonist. This compound showed moderate potency for 5-HT(1A) in binding and functional assays, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3870e7de874af8b9e1012a4ec29377a5
https://pubmed.ncbi.nlm.nih.gov/19147349

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Design and synthesis of reboxetine analogs morpholine derivatives as selective norepinephrine reuptake inhibitors

Autor: Wenjian Xu, Nancy Sue Barta, Shelly Ann Glase, David Gray

Publikováno v: Bioorganicmedicinal chemistry letters. 18(20)

As part of a discovery effort aimed at identifying novel norepinephrine reuptake inhibitors (NRIs), a number of substituted morpholines were designed and synthesized. The target compounds contain vicinal stereogenic centers, and the program was great

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d4d1323cdf376fa3b4907974ebf5169
https://pubmed.ncbi.nlm.nih.gov/18805691

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