Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nancy Spickofsky"'
Autor:
Alain Robichon, Peter J. McKinnon, Luis Ruiz-Avila, Susan K. McLaughlin, Nancy Spickofsky, Robert F. Margolskee, David Wildman
Publikováno v:
Nature. 376:80-85
THE rod and cone transducing are specific G proteins originally thought to be present only in photoreceptor cells of the vertebrate retina1–4. Transducins convert light stimulation of photoreceptor opsins into activation of cyclic GMP phosphodieste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00b8ae2b0253aee82d3bc1c7bc3992be
https://doi.org/10.1038/376080a0
https://doi.org/10.1038/376080a0
Autor:
Robert F. Margolskee, Nancy Spickofsky
Publikováno v:
Nucleic Acids Research. 19:7105-7111
A new procedure using an asymmetrically tailed linker-primer plasmid has been developed to prepare extremely high complexity cDNA libraries. This procedure yields plasmid primed libraries with a final form equivalent to those made by the procedure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3397e7b8f6d0ce349e53800194a57da9
https://doi.org/10.1093/nar/19.25.7105
https://doi.org/10.1093/nar/19.25.7105
Autor:
Alain Robichon, Peter J. McKinnon, Susan K. McLaughlin, Nancy Spickofsky, Robert F. Margolskee
Publikováno v:
Ciba Foundation Symposium 179 - The Molecular Basis of Smell and Taste Transduction
In the vertebrate taste cell, heterotrimeric guanine nucleotide-binding proteins (G proteins) are involved in the transduction of both bitter and sweet taste stimulants. The bitter compound denatonium raises the intracellular Ca2+ concentration in ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52f2fcda149401401248038650027dce
https://doi.org/10.1002/9780470514511.ch12
https://doi.org/10.1002/9780470514511.ch12
Autor:
Karen L. Abbott, Farooq Ahmed, Arun Anantharam, Nikolai O. Artemyev, Manjiri M. Bakre, Ann J. Barbier, Valerie Benard, Upinder S. Bhalla, Gary M. Bokoch, Valerie Boss, Jochen Buck, Martin J. Cann, Austin B. Capper, Kendall D. Carey, Mario Chiariello, Peter Clapp, Dermot M.F. Cooper, Svetlana Cvejic, Roger J. Davis, Carmen W. Dessauer, María A. Diversé-Pierluissi, Guanywei Du, Barbara J. Ebersole, Hironori Edamatsu, Michelle L. Ellington, John H. Exton, David A. Fancy, Michael A. Frohman, Alfred G. Gilman, Maria Grazia Giovannini, Alexey E. Granovsky, J. Silvio Gutkind, Stephen Gutowski, J. Perry Hall, Yusuf A. Hannun, Mark E. Hatley, Brian A. Hemmings, Michelle M. Hill, Akira Hirasawa, Xin-Yun Huang, Xi-Ping Huang, Hiroshi Ikawa, Soren Impey, Hiroshi Itoh, Ravi Iyengar, Xuejun Jiang, Taihao Jin, J. Dedrick Jordan, Richard A. Kahn, Yoshinori Kaminishi, Susumu Katsuma, Yoshito Kaziro, Jun Kuai, Ha Kun Kim, Lonny R. Levin, Yu Liu, Diomedes E. Logothetis, Coeli Lopes, James R. Loss II, William E. Lowry, Yong-Chao Ma, Junhao Mao, Robert F. Margolskee, Marianna Max, Daniel F. McCain, Kathryn E. Meier, Tooraj Mirshahi, Daria Mochly-Rosen, Kosei Moriyama, Andrew J. Morris, Deborah K. Morrison, Joel Moss, Jürgen Müller, Masatoshi Murai, T.J. Murphy, Alexandra C. Newton, Jim Nichols, Karl Obrietan, Tadaaki Ohgi, Gustavo Pacheco-Rodriguez, Tarun B. Patel, Grace K. Pavlath, Gülhan Pilli, Prahlad T. Ram, Aaron M. Robida, Tibor Rohács, Arnold E. Ruoho, Suzanne Scarlata, Deborah Schechtman, Klaus Scholich, Vicki A. Sciorra, Stuart C. Sealfon, Kenneth B. Seamon, Satoshi Shiojima, Michael K. Sievert, Paola Signorelli, Meeghan L. Sinclair, William D. Singer, Xiaosong Song, Nancy Spickofsky, Stephen R. Sprang, Paul C. Sternweis, Philip J.S. Stork, Daniel R. Storm, Roger K. Sunahara, Elizabeth M. Sutkowski, Yasuhito Suzuki, Kazuchika Takagaki, Wei-Jen Tang, Jiangchuan Tao, Ronald Taussig, John J.G. Tesmer, Gozoh Tsujimoto, Martha Vaughan, Hsien-Yu Wang, Xiaofei Wang, Clark Wells, Claus Wittpoth, Scott T. Wong, Rudiger Woscholski, Dianqing Wu, Yuhuan Xie, Zhi Xie, Kaiming Xu, Shui-Zhong Yan, Junichi Yano, Yinges Yigzaw, Tony Yuen, Hailin Zhang, Wen Zhang, Zhong-Yin Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59aacf85bb6054209c764199eabcee59
https://doi.org/10.1016/s0076-6879(02)45000-8
https://doi.org/10.1016/s0076-6879(02)45000-8
Autor:
Robert F. Margolskee, Nancy Spickofsky, Manjiri M. Bakre, Kosei Moriyama, Farooq Ahmed, Marianna Max
Regulation of retinal phosphodiesterase (PDE) by the transducins is well known, and essential to signal transduction in both rod and cone photoreceptor cells of the retina. Data suggest that G proteins may regulate other PDE isoforms in nonretinal se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3013402b1182adc6c62e631e72e30e8
https://doi.org/10.1016/s0076-6879(02)45005-7
https://doi.org/10.1016/s0076-6879(02)45005-7
Publikováno v:
Physiologybehavior. 56(6)
To identify and characterize those proteins involved in taste transduction, we cloned G proteins and phosphodiesterases from rat taste tissue. Using degenerate primers corresponding to conserved regions of G protein alpha subunits, the polymerase cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01c00651377509f80930e555bc8a8b7
https://pubmed.ncbi.nlm.nih.gov/7878085
https://pubmed.ncbi.nlm.nih.gov/7878085
Autor:
Vincent S. Madison, Nancy Spickofsky, Robert F. Margolskee, Alain Robichon, David N. Greeley, David C. Fry, Bradford Graves, Waleed Danho
Publikováno v:
Nature structural biology. 1(11)
In vertebrate rod cells, the activated alpha-subunit of rod transducin interacts with the gamma (regulatory) subunits of phosphodiesterase to disinhibit the catalytic subunits. A 22-amino acid long region of rod transducin involved in phosphodiestera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0959d24c127eb75bb7a871ec21af79
https://pubmed.ncbi.nlm.nih.gov/7634079
https://pubmed.ncbi.nlm.nih.gov/7634079
Publikováno v:
Olfaction and Taste XI ISBN: 9784431683575
The molecular mechanisms underlying taste transduction have been only partially elucidated. Each taste submodality has its own specific mechanism: salty taste results from Na+ flux through apical Na+ channels; sour is mediated by H+ ion blockade of K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f58381be9ef357dd9be273cbede78b2
https://doi.org/10.1007/978-4-431-68355-1_25
https://doi.org/10.1007/978-4-431-68355-1_25
Publikováno v:
Gene. 111(2)
Tumor necrosis factor (TNF) is a cytokine with pleiotropic effects upon cell growth, inflammation and immunologic responsiveness. High-affinity TNF receptors (TNFRs) of 55 and 75 kDa are found in many cell types. Using an Epstein-Barr virus (EBV)-bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1e6ee715cf67911b37f4809caf8274
https://pubmed.ncbi.nlm.nih.gov/1311700
https://pubmed.ncbi.nlm.nih.gov/1311700