Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Nancy S. Hayes"'
Autor:
Minal Patel, Grace M. Quaker, Hyun O. Ok, Lin Chu, Amy Galka, Annie Zhao, Jane Lo, Heather L. Sings, Jisong Cui, Amy F. Cheng, Lawrence F. Colwell, Stephanie L. Witkin, Feroze Ujjainwalla, John G. Menke, Debra Ondeyka, Helen M. Armstrong, Linda L. Chang, Nancy S. Hayes, Jilly F. Evans, Mark T. Goulet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4133-4138
A search for a suitable replacement for the central norbornyl scaffold presented in the recently disclosed novel FLAP inhibitors is herein described, as well as the SAR study performed on the endo and exo-aryl groups.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39018473b521181150efe29b747a22e4
https://doi.org/10.1016/j.bmcl.2012.04.064
https://doi.org/10.1016/j.bmcl.2012.04.064
Autor:
Neelam Sharma, Weiguo Liu, Nancy S. Hayes, Steve Chen, Melba Hernandez, John G. Menke, Carl P. Sparrow, Michael Robins, James F. Dropinski, Michael J. Szymonifka, Lawrence F. Colwell, Sheo B. Singh, Charlotte Burton, Karen L. MacNaul
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4574-4578
A series of podocarpic acid amides were identified as potent agonists for Liver X receptor alpha and beta subtypes, which are members of a nuclear hormone receptor superfamily that are involved in the regulation of a variety of metabolic pathways inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98d886c2edbeb4cb3dc478b4f411a44
https://doi.org/10.1016/j.bmcl.2005.06.100
https://doi.org/10.1016/j.bmcl.2005.06.100
Autor:
Hiranthi Jayasuriya, Anne W. Dombrowski, Ziqiang Guan, John G. Ondeyka, Marvin D. Schulman, Sheo B. Singh, John G. Menke, Christine McCallum, Kithsiri Herath, Soojin S Kwon, Karen L. MacNaul, Javier Collado, Nancy S. Hayes, Neelam Sharma
Publikováno v:
The Journal of Antibiotics. 58:559-565
Cholesterol homeostasis is tightly controlled process that involves a variety of regulators including liver X receptors (LXR). Agonists of LXR are expected to increase cholesterol efflux, lower LDL, and raise HDL levels. Screening of a natural produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493a7fb7e07656b92b6387e04c54f8c8
https://doi.org/10.1038/ja.2005.76
https://doi.org/10.1038/ja.2005.76
Autor:
Joanne Baffic, Yu-Sheng Chao, A. Brian Jones, Weiguo Liu, Steve Chen, John G. Menke, Carl P. Sparrow, Melba Hernandez, Sherrie X McCormick, Xiaohua Li, Aileen Bouffard, Tom S. Chen, John G. Ondeyka, James F. Dropinski, Jianhua Wang, Neelam Sharma, Sheo B. Singh, Karen L. MacNaul, Charlotte Burton, Nancy S. Hayes, My-Hanh Lam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2824-2828
Liver X receptors are nuclear receptors that regulate metabolism of cholesterol. They are activated by oxysterols resulting in increased transcription of the ABCA1 gene, promoting cholesterol efflux and HDL formation. We have identified podocarpic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91291554a85a4cdd26920f44ff0310f
https://doi.org/10.1016/j.bmcl.2005.03.100
https://doi.org/10.1016/j.bmcl.2005.03.100
Autor:
Bei Zhang, Gregory D. Berger, Chhabi Biswas, Robert W. Marquis, Joel Berger, Richard L. Tolman, Conrad Santini, Roy G. Smith, Ying Li, Gaochou Zhou, Margaret Wu, John Ventre, Nancy S. Hayes, David E. Moller, Thomas W. Doebber, Michael R. Tanen, Soumya P. Sahoo, Alex Elbrecht, Mark D. Leibowitz, Catherine A. Cullinan, Ralph T. Mosley
Publikováno v:
Journal of Biological Chemistry. 274:6718-6725
The peroxisome proliferator-activated receptors (PPARs) include three receptor subtypes encoded by separate genes: PPARalpha, PPARdelta, and PPARgamma. PPARgamma has been implicated as a mediator of adipocyte differentiation and the mechanism by whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d759ee2bf37a009fb5d374059ed9f683
https://doi.org/10.1074/jbc.274.10.6718
https://doi.org/10.1074/jbc.274.10.6718
Autor:
Nancy S. Hayes, Joel P. Berger
Publikováno v:
Analytical Biochemistry. 261:159-163
Skeletal muscle is the major tissue responsible for insulin-stimulated glucose uptake and incorporation into glycogen. Skeletal muscle insulin resistance and the resulting postprandial hyperglycemia are hallmarks of non-insulin-dependent diabetes. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f377e416b2829c61a260a880bd730a
https://doi.org/10.1006/abio.1998.2745
https://doi.org/10.1006/abio.1998.2745
Publikováno v:
Endocrinology. 137:1984-1990
Thiazolidinedione derivatives are a novel class of insulin-sensitizing agents that have demonstrated effective antidiabetic activity in vivo. Here, the effects of the potent thiazolidinedione derivative, AD-5075, on the rate-limiting enzyme of glycog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ec30497cb346312dd4cd5dba95052a
https://doi.org/10.1210/endo.137.5.8612539
https://doi.org/10.1210/endo.137.5.8612539
Publikováno v:
Journal of Biological Chemistry. 269:25735-25741
Thiazolidinedione derivatives are insulin-sensitizing agents with proven antidiabetic activities in vivo. To explore the mechanism of action of this class of compounds, the effects of pioglitazone, CP-86,325, and AD-5075 on elements of the insulin si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::328d7aa3e92db670426d7754557e73ef
https://doi.org/10.1016/s0021-9258(18)47309-7
https://doi.org/10.1016/s0021-9258(18)47309-7
Publikováno v:
Personality and Social Psychology Bulletin. 20:170-177
This research investigated the influence of distraction on subjects' impressions and memory while in positive and negative moods. Subjects' incidental memory for affective traits used as a basis for forming an impression of a target person was assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::475cf835011c2ea7a569738034b2e0b8
https://doi.org/10.1177/0146167294202004
https://doi.org/10.1177/0146167294202004
Autor:
Nancy S. Hayes, Catherine E. Seta
Publikováno v:
Personality and Social Psychology Bulletin. 20:93-101
The influence of different impression formation goals on memory for the sources of social actions was investigated. Subjects read stereotype-constant and stereotype-inconsistent actions of target individuals described by both proper names and group a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a23597b033aadce00a498c3d12fa4260
https://doi.org/10.1177/0146167294201009
https://doi.org/10.1177/0146167294201009