Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Nancy Ratner"'
Autor:
Siddhi N. Paudel, Brian J. Hutzen, Katherine E. Miller, Elizabeth A. R. Garfinkle, Chun-Yu Chen, Pin-Yi Wang, Andrea M. Glaspell, Mark A. Currier, Emily M. Ringwalt, Louis Boon, Elaine R. Mardis, Mitchell S. Cairo, Nancy Ratner, Rebecca D. Dodd, Kevin A. Cassady, Timothy P. Cripe
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/aea62abb85594bdd81547a1e4aff9626
Autor:
Jennifer Patritti-Cram, Eric P. Rahrmann, Tilat A. Rizvi, Katherine C. Scheffer, Timothy N. Phoenix, David A. Largaespada, Nancy Ratner
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110294- (2024)
Summary: The blood-nerve-barrier (BNB) that regulates peripheral nerve homeostasis is formed by endoneurial capillaries and perineurial cells surrounding the Schwann cell (SC)-rich endoneurium. Barrier dysfunction is common in human tumorigenesis, in
Externí odkaz:
https://doaj.org/article/b2e4f7d4622f4f9db1bac7a662c21301
Autor:
Siddhi N. Paudel, Brian J. Hutzen, Katherine E. Miller, Elizabeth A. R. Garfinkle, Chun-Yu Chen, Pin-Yi Wang, Andrea M. Glaspell, Mark A. Currier, Emily M. Ringwalt, Louis Boon, Elaine R. Mardis, Mitchell S. Cairo, Nancy Ratner, Rebecca D. Dodd, Kevin A. Cassady, Timothy P. Cripe
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionMalignant peripheral nerve sheath tumors (MPNST) pose a significant therapeutic challenge due to high recurrence rates after surgical resection and a largely ineffective response to traditional chemotherapy. An alternative treatment strat
Externí odkaz:
https://doaj.org/article/30c6602860ac408d8659f1b13326bd9a
Autor:
Miriam Magallón-Lorenz, Ernest Terribas, Sara Ortega-Bertran, Edgar Creus-Bachiller, Marco Fernández, Gerard Requena, Inma Rosas, Helena Mazuelas, Itziar Uriarte-Arrazola, Alex Negro, Tereza Lausová, Elisabeth Castellanos, Ignacio Blanco, George DeVries, Hiroyuki Kawashima, Eric Legius, Hilde Brems, Viktor Mautner, Lan Kluwe, Nancy Ratner, Margaret Wallace, Juana Fernández-Rodriguez, Conxi Lázaro, Jonathan A. Fletcher, David Reuss, Meritxell Carrió, Bernat Gel, Eduard Serra
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106096- (2023)
Summary: Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas of the peripheral nervous system that develop either sporadically or in the context of neurofibromatosis type 1 (NF1). MPNST diagnosis can be challenging and treatmen
Externí odkaz:
https://doaj.org/article/47d61282e05c49bc9cb540ffd4fb4a24
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281876 (2023)
Neurofibromatosis Type 2 is an inherited disease characterized by Schwann cell tumors of cranial and peripheral nerves. The NF2 gene encodes Merlin, a member of the ERM family consisting of an N-terminal FERM domain, a central α-helical region, and
Externí odkaz:
https://doaj.org/article/f999f2a55ba541cbb2dca0312033a332
Autor:
Leah J. Kershner, Kwangmin Choi, Jianqiang Wu, Xiyuan Zhang, Melissa Perrino, Nathan Salomonis, Jack F. Shern, Nancy Ratner
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
To define alterations early in tumor formation, we studied nerve tumors in neurofibromatosis 1 (NF1), a tumor predisposition syndrome. Affected individuals develop neurofibromas, benign tumors driven by NF1 loss in Schwann cells (SCs). By comparing n
Externí odkaz:
https://doaj.org/article/50276e58914543fb9bda0e1f1e2739c2
Autor:
Jennifer Patritti Cram, Jianqiang Wu, Robert A Coover, Tilat A Rizvi, Katherine E Chaney, Ramya Ravindran, Jose A Cancelas, Robert J Spinner, Nancy Ratner
Publikováno v:
eLife, Vol 11 (2022)
Neurofibromatosis type 1 (NF1) is characterized by nerve tumors called neurofibromas, in which Schwann cells (SCs) show deregulated RAS signaling. NF1 is also implicated in regulation of cAMP. We identified the G-protein-coupled receptor (GPCR) P2ry1
Externí odkaz:
https://doaj.org/article/cb19eefec69648a0af42e1875c368a55
Autor:
Kwangmin Choi, Nancy Ratner
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-7 (2019)
Abstract Background The use of microarrays and RNA-seq technologies is ubiquitous for transcriptome analyses in modern biology. With proper analysis tools, the differential gene expression analysis process can be significantly accelerated. Many open-
Externí odkaz:
https://doaj.org/article/b90c01e4d2e84debae23b11965acb796
Autor:
Robert A. Coover, Tabitha E. Healy, Li Guo, Katherine E. Chaney, Robert F. Hennigan, Craig S. Thomson, Lindsey E. Aschbacher-Smith, Michael P. Jankowski, Nancy Ratner
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity in adult nerves causes SC to enter the cell cycle. In vitro, ATP activates
Externí odkaz:
https://doaj.org/article/1bfa1d5d9ede4c02abd2406952f3a5c2
Autor:
Vishnu Modur, Navneet Singh, Vakul Mohanty, Eunah Chung, Belal Muhammad, Kwangmin Choi, Xiaoting Chen, Kashish Chetal, Nancy Ratner, Nathan Salomonis, Matthew T. Weirauch, Susan Waltz, Gang Huang, Lisa Privette-Vinnedge, Joo-Seop Park, Edith M. Janssen, Kakajan Komurov
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Transcription elongation (TE) is a key point of inducible gene expression regulation. Here, the authors report widespread TE defects (TEdeff) in a high proportion of cancers that correlate with poor immunotherapy response, highlighting TE defects as
Externí odkaz:
https://doaj.org/article/942ee42acc244ca2beabb5d1cf1d3a26