Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Nancy R. Nichols"'
Autor:
Mark I. Ransome, Ann M. Turnley, Nikla R. Emambokus, Jon Frampton, Robert G. Ramsay, Sally Lightowler, Jordane Malaterre, Qing Yang, Sebastian Dworkin, Nancy R Nichols, Theo Mantamadiotis
Publikováno v:
Stem Cells. 26:173-181
Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathol
Autor:
Samuel McLenachan, Nancy R. Nichols, Claire E. Walters, Ann M. Turnley, Martin J. Stebbing, Hannah J. Scott, Mark I. Ransome
Publikováno v:
Brain Research. 1067:138-145
Neuronal differentiation of neural progenitor cells is regulated by a variety of growth and transcription factors, that not only regulate cell fate of the progenitor cells but that can also regulate neuronal morphology. Suppressor of cytokine signali
Autor:
Nancy R. Nichols
Publikováno v:
Annals of the New York Academy of Sciences. 1007:349-356
Previously, we cloned a gene from rat hippocampus that now shows homology to Ndrg2, a member of the N-myc downregulated gene (NDRG) family with putative roles in neural differentiation, synapse formation, and axon survival. Following adrenalectomy, h
Autor:
Caleb E. Finch, C S Young-Chan, D K Sarkar, Nicholas J. Laping, Irina Rozovsky, Todd E. Morgan, Nancy R. Nichols
Publikováno v:
Neuroscience. 101:313-321
Transforming growth factor-beta1 is a multifunctional peptide with increased expression during Alzheimer's disease and other neurodegenerative conditions which involve inflammatory mechanisms. We examined the autoregulation of transforming growth fac
Autor:
Nancy R Nichols
Publikováno v:
Journal of Neurobiology. 40:585-601
Glia mediate neuroendocrine and neuroimmune functions that are altered during the process of normal aging. The biological functions of glia are also important in synaptic remodeling and the loss of synaptic connections that occur during aging. These
Autor:
Nicole Bye, Nancy R. Nichols
Publikováno v:
NeuroReport. 9:1179-1184
Cell death by apoptosis occurs in mature neurones of adult rat dentate gyrus following adrenalectomy. In these studies, apoptosis in the dentate gyrus was induced 3 days after adrenalectomy in male Fischer 344 rats ranging in age from 2-3 to 24-26 mo
Publikováno v:
Neuroendocrinology. 63:28-38
A novel cDNA clone, CR16, was isolated from a rat hippocampal cDNA library and characterized for responses to corticosteroids and regional expression. The 4-kb RNA was increased 3-fold by treatment of adrenalectomized (ADX) rats with corticosterone (
Publikováno v:
Neurobiology of Aging. 16:105-110
Astrogliosis with advancing age is correlated with increased expression of glial fibrillary acidic protein (GFAP). Hypothalamic GFAP mRNA prevalence was determined in male F344 rats of different ages that were fed ad lib (AL) and compared with that o
Publikováno v:
Endocrinology. 135:1928-1933
Transcriptional regulation of two astrocyte genes, glial fibrillary acidic protein (GFAP) and glutamine synthase (GS), by glucocorticoids was determined by nuclear run-on assay with hippocampal tissues from adult male F344 rats. Transcriptional respo
Publikováno v:
Brain Pathology. 4:259-275
Levels of glial fibrillary acidic protein (GFAP), an astrocyte-specific intermediate filament protein, are altered during development and aging, GFAP also responds dynamically to neurodegenerative lesions. Changes in GFAP expression can occur at both