Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Nancy R. Cox"'
Autor:
Hannah E. Rockwell, Victoria J. McCurdy, Samuel C. Eaton, Diane U. Wilson, Aime K. Johnson, Ashley N. Randle, Allison M. Bradbury, Heather L. Gray-Edwards, Henry J. Baker, Judith A. Hudson, Nancy R. Cox, Miguel Sena-Esteves, Thomas N. Seyfried, Douglas R. Martin
Publikováno v:
ASN Neuro, Vol 7 (2015)
Sandhoff disease (SD) is an autosomal recessive neurodegenerative disease caused by a mutation in the gene for the β-subunit of β-N-acetylhexosaminidase (Hex), resulting in the inability to catabolize ganglioside GM2 within the lysosomes. SD presen
Externí odkaz:
https://doaj.org/article/ca9dfbf3374b4466a2748535a40d9de2
Autor:
Tatiana I. Samoylova, Nancy R. Cox, Nancy E. Morrison, Ludmila P. Globa, Victor Romanov, Henry J. Baker, Valery A. Petrenko
Publikováno v:
BioTechniques, Vol 37, Iss 2, Pp 254-260 (2004)
Cell-binding ligands for RG2 rat glioma were identified in our recent study from a library of peptides that are displayed as fusion molecules on phage particles. Here, one of the phage clones was used to affinity purify those cell membrane components
Externí odkaz:
https://doaj.org/article/030a8e2e82ba4848b45776e1c940b1f1
Autor:
Emily C Graff, J Nicholas Cochran, Christopher B Kaelin, Kenneth Day, Heather L Gray-Edwards, Rie Watanabe, Jey W Koehler, Rebecca A Falgoust, Jeremy W Prokop, Richard M Myers, Nancy R Cox, Gregory S Barsh, Douglas R Martin, Lives Consortium
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1008671 (2020)
Cerebral cortical size and organization are critical features of neurodevelopment and human evolution, for which genetic investigation in model organisms can provide insight into developmental mechanisms and the causes of cerebral malformations. Howe
Externí odkaz:
https://doaj.org/article/f72c12a217e54356ab20a16d694c65c4
Autor:
Victoria J. McCurdy, Aime K. Johnson, Miguel Sena-Esteves, Nancy E. Morrison, Douglas R. Martin, Ashley N. Randle, Allison M. Bradbury, Heather L. Gray-Edwards, Misako Hwang, Henry J. Baker, Nancy R. Cox
Publikováno v:
Gene therapy
Sandhoff disease (SD) is an autosomal recessive lysosomal storage disease caused by defects in the β-subunit of β-N-acetylhexosaminidase (Hex), the enzyme that catabolizes GM2 ganglioside (GM2). Hex deficiency causes neuronal storage of GM2 and rel
Autor:
Aime K. Johnson, Tiffany A. Peterson, Ashley N. Randle, Victoria J. McCurdy, Allison M. Bradbury, Brandon L. Brunson, Edward E. Morrison, Karen G. Wolfe, Heather L. Gray-Edwards, Henry J. Baker, Miguel Sena-Esteves, Stephen Z. Wells, Nancy R. Cox, John C. Dennis, Douglas R. Martin, Amanda L. Gross
Publikováno v:
Neuroscience. 340:117-125
Sandhoff disease (SD) is a lysosomal storage disorder characterized by the absence of hydrolytic enzyme β-N-acetylhexosaminidase (Hex), which results in storage of GM2 ganglioside in neurons and unremitting neurodegeneration. Neuron loss initially a
Autor:
Ashley N. Randle, Heather L. Gray-Edwards, Ronald J. Beyers, Henry J. Baker, Judith A. Hudson, Adrien-Maxence Hespel, Merrilee Holland, Miguel Sena-Esteves, Victoria J. McCurdy, Douglas R. Martin, Thomas S. Denney, Meredith L. Voyles, Nancy R. Cox, Diane U. Wilson, Brandon L. Brunson, Allison M. Bradbury, Nouha Salibi, Ronald D. Montgomery, Aime K. Johnson, Patricia M. Beadlescomb
Publikováno v:
Molecular Genetics and Metabolism. 116:80-87
Sandhoff disease (SD) is a fatal neurodegenerative disease caused by a mutation in the enzyme β-N-acetylhexosaminidase. Children with infantile onset SD develop seizures, loss of motor tone and swallowing problems, eventually reaching a vegetative s
Autor:
Tatiana I. Samoylova, Nancy R. Cox, India D. Napier, Nancy E. Morrison, Alexandre M. Samoylov, Douglas R. Martin
Publikováno v:
Theriogenology. 83:266-275
GnRH receptors play vital roles in mammalian reproduction via regulation of gonadotropin secretion, which is essential for gametogenesis and production of gonadal steroids. GnRH receptors for more than 20 mammalian species have been sequenced, includ
Autor:
Victoria J. McCurdy, Gretchen Golas, Yvonne L. Latour, Douglas R. Martin, Allison M. Bradbury, Cynthia J. Tifft, Ashley N. Randle, Brandon L. Brunson, Donald C. Sorjonen, Amanda R. Taylor, Miguel Sena-Esteves, Henry J. Baker, Nouha Salibi, Annie S. Maguire, Sarah E. Thomas, Heather L. Gray-Edwards, Jamie L. Shirley, Ronald J. Beyers, Pete W. Christopherson, Aime K. Johnson, Jean M. Johnston, Nancy R. Cox, Debra S Regier, Thomas S. Denney
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 25(4)
GM1 gangliosidosis is a fatal neurodegenerative disease that affects individuals of all ages. Favorable outcomes using adeno-associated viral (AAV) gene therapy in GM1 mice and cats have prompted consideration of human clinical trials, yet there rema
Autor:
Karen G. Wolfe, Nancy R. Cox, Alexandre M. Samoylov, Tatiana I. Samoylova, Valery A. Petrenko, Mandy D. Norris, Anna M. Cochran
Publikováno v:
Journal of Virological Methods. 183:63-68
The focus of this study is on development of vaccines using filamentous phage as a delivery vector for immunogenic peptides. The use of phage as a carrier for immunogenic peptides provides significant benefits such as high immunogenicity, low product
Autor:
Tatiana I. Samoylova, Nancy R. Cox, Alexandre M. Samoylov, Henry J. Baker, Brenda Griffin, Anna M. Cochran
Publikováno v:
Animal Reproduction Science. 120:151-157
Zona pellucida (ZP) glycoproteins play a central role in sperm-oocyte binding and fertilization. Sperm protein sequences that are involved in sperm-ZP recognition and have an important role in fertilization represent attractive targets for developmen