Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Nancy R Zahniser"'
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95019 (2014)
Fructose accounts for 10% of daily calories in the American diet. Fructose, but not glucose, given intracerebroventricularly stimulates homeostatic feeding mechanisms within the hypothalamus; however, little is known about how fructose affects hedoni
Externí odkaz:
https://doaj.org/article/053ed3c59a74437cafaa365a799393f2
Autor:
Dorothy J Yamamoto, Nancy R Zahniser
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37673 (2012)
Sprague-Dawley rats can be classified as low or high cocaine responders (LCRs or HCRs, respectively) based on their locomotor activity induced by an acute low dose of cocaine. Upon repeated cocaine exposure, LCRs display greater locomotor sensitizati
Externí odkaz:
https://doaj.org/article/59cc6def8ac442bcb6329e8398d7245f
Autor:
Jorge E. Quintero, Martin Lundblad, David A. Price, Peter Huettl, Nancy R. Zahniser, Francois Pomerleau, Jason J. Burmeister, Greg A. Gerhardt
Publikováno v:
Applied Sciences
Volume 10
Issue 18
Applied Sciences, Vol 10, Iss 6449, p 6449 (2020)
Volume 10
Issue 18
Applied Sciences, Vol 10, Iss 6449, p 6449 (2020)
Here we report a novel microelectrode array recording approach to measure tonic (resting) and phasic release of dopamine (DA) in DA-rich areas such as the rat striatum and nucleus accumbens. The resulting method is tested in intact central nervous sy
Publikováno v:
Drug and Alcohol Dependence. 149:166-172
Background Escalation of consumption is a hallmark of cocaine addiction. Many animal models reveal escalation by increasing the duration of drug access (e.g., 6–24 h/day) after longer histories of self-administration. We recently developed a method
Autor:
Toni L. Richards, Bruce H. Mandt, Richard M. Allen, Diana L. Simmons, Christopher M.C. Ng, Nancy R. Zahniser, Dorothy J. Yamamoto
Publikováno v:
Neuropharmacology. 75:347-355
Behavioral responsiveness to initial cocaine use varies among individuals and may contribute to differential vulnerability to cocaine addiction. Rats also exhibit individual differences in cocaine’s effects and can be classified as low or high coca
Autor:
Bruce H. Mandt, Toni L. Richards, Gaynor A. Larson, Jacki M. Rorabaugh, Christopher M.C. Ng, Nancy R. Zahniser, Dorothy J. Yamamoto, Kelsey Barcomb, Richard M. Allen, Anna M. Nelson
Publikováno v:
Neuroscience & Biobehavioral Reviews. 37:1738-1753
Individual differences are a hallmark of drug addiction. Here, we describe a rat model based on differential initial responsiveness to low dose cocaine. Despite similar brain cocaine levels, individual outbred Sprague-Dawley rats exhibit markedly dif
Publikováno v:
Synapse. 67:668-677
Variations in the expression levels of the dopamine transporter (DAT) can influence responsiveness to psychostimulant drugs like cocaine. To better understand this relationship, we studied a new DAT-low expresser (DAT-LE) mouse model and performed be
Publikováno v:
The FASEB Journal. 26:1921-1933
The plasma membrane dopamine (DA) transporter (DAT) is essential for reuptake of extracellular DA. DAT function in heterologous cells is regulated by subcellular targeting, endocytosis, and intracellular trafficking, but the mechanisms regulating neu
Autor:
Tim A. Benke, Nancy R. Zahniser, Elizabeth A. Stubblefield, Aik Choon Tan, Barbara C. Blanchard, John R. Sladek, Toni L. Richards, Fang Li, Yujun He, Dabing Zhang, Qian Huang, Xinjian Liu, Gaynor A. Larson, Chuan-Yuan Li
Publikováno v:
Cell Research
Transplantation of exogenous dopaminergic neuron (DA neurons) is a promising approach for treating Parkinson's disease (PD). However, a major stumbling block has been the lack of a reliable source of donor DA neurons. Here we show that a combination
Publikováno v:
Neuroscience Letters. 476:9-13
Humans differ in their initial response to, and subsequent abuse of, addictive drugs like cocaine. Rodents also exhibit marked individual differences in responsiveness to cocaine. Previously, we classified male Sprague–Dawley rats as either low or