Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Nancy Pryer"'
Autor:
Yuanbin Ru, Carley Corado, Russell K. Soon Jr, Andrew C. Melton, Adam Harris, Guoying K. Yu, Nancy Pryer, John R. Sinclair, Martin L. Katz, Temitayo Ajayi, David Jacoby, Chris B. Russell, Sanjay Chandriani
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 12, Pp 2437-2447 (2019)
Abstract Objective Neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is a rare, progressive, fatal neurodegenerative pediatric disorder resulting from deficiencies of the lysosomal enzyme tripeptidyl peptidase 1 that are caused by mutations in TPP
Externí odkaz:
https://doaj.org/article/f1502f91d5a84d26a84b4e9377e1f3b7
Autor:
Siew C. Schleyer, Judith A. Abraham, Paul Kwon, Emma Lees, William R. Sellers, Seth A. Ettenberg, William Kluwe, Nancy Pryer, Jocelyn Holash, Si Tuen Lee-Hoeflich, Keith Mansfield, Majid Ghoddusi, Zhen Wang, Francesco Galimi, Klaus Krauser, Dana Walker, Sarah Harris, Marjorie Ison-Dugenny, Janine Kline, Xiaohong Niu, E. Erica Hong, Kathy Miller, Thomas Huber, Steven B. Cohen, Christie Fanton, Anu Connor, Tinya Abrams
Figure S1. RNASeq data across multiple tumor types indicate c-KIT overexpression in a subset of cancer types such as AML, melanoma, testicular germ cell cancer and lung cancer. This was obtained from the TCGA data set. Figure S2. Western blot analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8fb5fb410540e85326af7553f4d810
https://doi.org/10.1158/1078-0432.22470618
https://doi.org/10.1158/1078-0432.22470618
Autor:
Siew C. Schleyer, Judith A. Abraham, Paul Kwon, Emma Lees, William R. Sellers, Seth A. Ettenberg, William Kluwe, Nancy Pryer, Jocelyn Holash, Si Tuen Lee-Hoeflich, Keith Mansfield, Majid Ghoddusi, Zhen Wang, Francesco Galimi, Klaus Krauser, Dana Walker, Sarah Harris, Marjorie Ison-Dugenny, Janine Kline, Xiaohong Niu, E. Erica Hong, Kathy Miller, Thomas Huber, Steven B. Cohen, Christie Fanton, Anu Connor, Tinya Abrams
Purpose: c-KIT overexpression is well recognized in cancers such as gastrointestinal stromal tumors (GIST), small cell lung cancer (SCLC), melanoma, non–small cell lung cancer (NSCLC), and acute myelogenous leukemia (AML). Treatment with the small-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bba4133dc134621088072ace928ec94
https://doi.org/10.1158/1078-0432.c.6527631
https://doi.org/10.1158/1078-0432.c.6527631
Autor:
Darrin Stuart, Frank McCormick, Nancy Pryer, Dylan Daniel, Majid Ghoddusi, Caroline Robert, Stephan Vagner, Michel Favre, Gorana Tomasic, Ludovic Lacroix, Lise Boussemart, Lisa Lomovasky, Ben Weisburd, Edward Lorenzana, Matthew Holderfield
PDF file - 507K, Koilocyte-like cells observed in an HPV negative verrucous papilloma (S1); H&E and pERK staining of gastric epithelium from mice treated for 60 days with 60 mg/kg Vemurafenib (S2); pERK staining of Vemurafenib and vehicle treated cSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10899308067b287c8bbcb20dedc13d65
https://doi.org/10.1158/0008-5472.22401554
https://doi.org/10.1158/0008-5472.22401554
Supplementary Table 1 from Vemurafenib Cooperates with HPV to Promote Initiation of Cutaneous Tumors
Autor:
Darrin Stuart, Frank McCormick, Nancy Pryer, Dylan Daniel, Majid Ghoddusi, Caroline Robert, Stephan Vagner, Michel Favre, Gorana Tomasic, Ludovic Lacroix, Lise Boussemart, Lisa Lomovasky, Ben Weisburd, Edward Lorenzana, Matthew Holderfield
PDF file - 50K, RAS mutation and HPV status of cutaneous lesions by histological type.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1496d2cc4c36a1229dde61a3e53b5980
https://doi.org/10.1158/0008-5472.22401551.v1
https://doi.org/10.1158/0008-5472.22401551.v1
Autor:
Darrin Stuart, Frank McCormick, Nancy Pryer, Dylan Daniel, Majid Ghoddusi, Caroline Robert, Stephan Vagner, Michel Favre, Gorana Tomasic, Ludovic Lacroix, Lise Boussemart, Lisa Lomovasky, Ben Weisburd, Edward Lorenzana, Matthew Holderfield
Treatment with RAF inhibitors such as vemurafenib causes the development of cutaneous squamous cell carcinomas (cSCC) or keratoacanthomas as a side effect in 18% to 30% of patients. It is known that RAF inhibitors activate the mitogen—activated pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28ddd42aaaac784e66342e40a961e70a
https://doi.org/10.1158/0008-5472.c.6505880
https://doi.org/10.1158/0008-5472.c.6505880
Autor:
Russell K. Soon, Temitayo Ajayi, Nancy Pryer, Guoying K. Yu, John Sinclair, Sanjay Chandriani, Andrew Melton, Carley R. Corado, Yuanbin Ru, Adam Harris, Chris B. Russell, David Jacoby, Martin L. Katz
Publikováno v:
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, Vol 6, Iss 12, Pp 2437-2447 (2019)
Annals of Clinical and Translational Neurology, Vol 6, Iss 12, Pp 2437-2447 (2019)
Objective Neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is a rare, progressive, fatal neurodegenerative pediatric disorder resulting from deficiencies of the lysosomal enzyme tripeptidyl peptidase 1 that are caused by mutations in TPP1. Identi
Autor:
Chi Ying, Jane Gu, Yan Tang, Suzanna Clark, Ursula Jeffry, Kathy Miller, Rick Newcombe, Qing Sheng, Christopher Karim, GiNell Elliot, Tinya Abrams, Thomas Huber, Jason Damiano, Katherine Rendahl, Paul Kwon, Angela Tam, Nancy Pryer, Majid Ghoddusi, Daniel Menezes, William R. Tschantz, Margaret E. McLaughlin, Emma Lees, Christie Fanton, Jean-Michel Rondeau, S. Lehmann, Anu Connor, Judith A. Abraham, Joseph Anthony D'alessio, Felipe Correa Geyer, Keith Mansfield
Publikováno v:
Molecular cancer therapeutics. 20(7)
The cell surface glycoprotein P-cadherin is highly expressed in a number of malignancies, including those arising in the epithelium of the bladder, breast, esophagus, lung, and upper aerodigestive system. PCA062 is a P-cadherin specific antibody–dr
Autor:
Fabian Von Arx, Fergal Casey, Sonja Tobler, Robert Cozens, Ying Liang, En Li, E. Robert McDonald, John Monahan, Audrey Kauffmann, Chao Zhang, Hans Bitter, Daniel Wyss, Mallika Singh, Edward Lorenzana, Tara L. Naylor, Francesco Hofmann, Rebecca Leary, Peter Atadja, Alice Loo, Fiona Xu, Anupama Reddy, Hongbo Cai, Ernesta Dammassa, Margaret E. McLaughlin, Shannon Chuai, Yun Zhang, Fernando Salangsang, Susmita Chatterjee, Christian Schnell, Stephanie Barbe, Hui Gao, Michael Rugaard Jensen, Youzhen Wang, Nicholas Keen, William R. Sellers, Millicent Embry, O. Alejandro Balbin, John Green, Marion Wiesmann, Joseph Lehar, Francesca Santacroce, Guizhi Yang, Claudia Roelli, Scott D. Collins, Kavitha Venkatesan, Colleen Kowal, Hui Qin Wang, Montesa Patawaran, Angad P Singh, Jason Merkin, Juliet Williams, Walter Tinetto, Roberto Velazquez, Emma Lees, Stephane Ferretti, Ronald Meyer, Nicolas Ebel, Shawn Cogan, Joshua M. Korn, David A. Ruddy, Zongyao Wang, Yan Tang, Derek Y. Chiang, Nancy Pryer
Publikováno v:
Nature Medicine. 21:1318-1325
Profiling candidate therapeutics with limited cancer models during preclinical development hinders predictions of clinical efficacy and identifying factors that underlie heterogeneous patient responses for patient-selection strategies. We established
Autor:
Paul Kwon, Keith Mansfield, Sarah Harris, Tinya Abrams, Emma Lees, Siew Schleyer, Christie Fanton, Nancy Pryer, Thomas Huber, Francesco Galimi, William R. Sellers, Si Tuen Lee-Hoeflich, Majid Ghoddusi, Anu Connor, Steven Cohen, Seth Ettenberg, Klaus R Krauser, Xiaohong Niu, Janine Kline, Zhen Wang, Judith A. Abraham, Marjorie Ison-Dugenny, E. Erica Hong, Jocelyn Holash, Dana B. Walker, Kathy Miller, William Kluwe
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 24(17)
Purpose: c-KIT overexpression is well recognized in cancers such as gastrointestinal stromal tumors (GIST), small cell lung cancer (SCLC), melanoma, non–small cell lung cancer (NSCLC), and acute myelogenous leukemia (AML). Treatment with the small-