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Autor:
Girish M. Shah, Mihaela Robu, Nancy Petitclerc, Rashmi G. Shah, Julie Brind’Amour, Febitha Kandan-Kulangara
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(5)
Among the earliest responses of mammalian cells to DNA damage is catalytic activation of a nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1). Activated PARP-1 forms the polymers of ADP-ribose (pADPr or PAR) that posttranslationally modify its tar