Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nancy Manley"'
Publikováno v:
The Journal of Immunology. 206:93.12-93.12
The generation of a functional, self-tolerant T cell repertoire depends on interactions between developing thymocytes and antigen-presenting thymic epithelial cells (TECs). The presentation of self-antigens to developing thymocytes involves a variety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0de6b5a0fa3df52d75aaf7a596d47e0e
https://doi.org/10.4049/jimmunol.206.supp.93.12
https://doi.org/10.4049/jimmunol.206.supp.93.12
Autor:
Maria Gracia Garcia Mendoza, Virginia Bain, Kaitlin A. Reeh, Nancy Manley, James F. Martin, Ellen R Richie
Publikováno v:
The Journal of Immunology. 198:60.1-60.1
The thymus develops bilaterally from third pharyngeal pouch (3rd pp) endoderm, which is initially patterned into separate thymus and parathyroid specific domains. The transcription factors FOXN1 and GCM2 are expressed in 3rd pp thymus-fated or parath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::843555db8e03a93ecde2e769d8de09a9
https://doi.org/10.4049/jimmunol.198.supp.60.1
https://doi.org/10.4049/jimmunol.198.supp.60.1
Publikováno v:
The Journal of Immunology. 196:122.13-122.13
The postnatal thymus is an efficient microenvironment for T cell specification and differentiation. B cells are also present in the thymus, and have been recently implicated in the central tolerance. In Foxn1lacZmutant mice, which undergo premature t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9010c3d77dd11c0d9a08a5418e709755
https://doi.org/10.4049/jimmunol.196.supp.122.13
https://doi.org/10.4049/jimmunol.196.supp.122.13
Publikováno v:
The Journal of Immunology. 194:188.16-188.16
Total Body Irradiation (TBI) dramatically damages the BM and thymus organs, however the long-term effects of irradiation and aging on both BM cells and thymocytes are still unclear. In this study, we described that although the kinetics of thymocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6d5e6dd902995ff80eaae071e8124b
https://doi.org/10.4049/jimmunol.194.supp.188.16
https://doi.org/10.4049/jimmunol.194.supp.188.16
Publikováno v:
The Journal of Immunology. 194:188.12-188.12
The thymus and parathyroids originate from bilateral 3rd pharyngeal pouch (pp) endoderm. At E11.5, thymus- and parathyroid-fated domains express Foxn1 and Gcm2 respectively, transcription factors that regulate differentiation but do not specify organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::016a96008f4295503010795edcffa87a
https://doi.org/10.4049/jimmunol.194.supp.188.12
https://doi.org/10.4049/jimmunol.194.supp.188.12
Publikováno v:
The Journal of Immunology. 194:188.15-188.15
The third pharyngeal pouch is an endodermally derived epithelium that differentiates into thymus and parathyroid cells. Foxn1 (transcription factor) is a thymus-specific marker, which is required for thymic epithelial cell (TEC) proliferation and dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc5b4f35f8dc81238c040cc8e0dca8cc
https://doi.org/10.4049/jimmunol.194.supp.188.15
https://doi.org/10.4049/jimmunol.194.supp.188.15
Publikováno v:
The Journal of Immunology. 192:116.12-116.12
The postnatal thymus is a highly efficient microenvironment for promoting T cell specification and differentiation. However, hematopoietic stem cells (HSCs) possess age-dependent differences in differentiation potential into T or B cells, with fetal-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f7ccc9dcb3b3065401fb5ca501587f0
https://doi.org/10.4049/jimmunol.192.supp.116.12
https://doi.org/10.4049/jimmunol.192.supp.116.12
Publikováno v:
The Journal of Immunology. 188:115.8-115.8
To study the effects of A-bomb radiation on immunosenescence, we developed a mouse model to evaluate the effects of sub-lethal gamma irradiation, varying exposure dose and analysis time points in males and females. The current data report the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e3a7edc991adc6ea90240bd375ecd97
https://doi.org/10.4049/jimmunol.188.supp.115.8
https://doi.org/10.4049/jimmunol.188.supp.115.8
Publikováno v:
The Journal of Immunology. 188:111.34-111.34
The thymus is the main source of naïve T cell output. As the body ages, the thymus undergoes involution, causing a drop in naïve T cell availability in the peripheral T cell pool. The molecular mechanisms underpinning thymic involution are not we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea5151d5db671d84afaeaefca9ea57f3
https://doi.org/10.4049/jimmunol.188.supp.111.34
https://doi.org/10.4049/jimmunol.188.supp.111.34