Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Nancy M. Walker"'
Autor:
Ashlee M. Strubberg, Jinghua Liu, Nancy M. Walker, Casey D. Stefanski, R. John MacLeod, Scott T. Magness, Lane L. Clarke
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 253-271 (2018)
Cystic fibrosis (CF) patients and CF mouse models have increased risk for gastrointestinal tumors. CF mice show augmented intestinal proliferation of unknown etiology and an altered intestinal environment. We examined the role of the cystic fibrosis
Externí odkaz:
https://doaj.org/article/00811421a58b4d72b94f13106358ec4c
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Goblet cell hyperplasia is an important manifestation of cystic fibrosis (CF) disease in epithelial-lined organs. Explants of CF airway epithelium show normalization of goblet cell numbers; therefore, we hypothesized that small intestinal enteroids f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea1c0e7e21b90a52a4546d1934ef35d
https://europepmc.org/articles/PMC8793866/
https://europepmc.org/articles/PMC8793866/
Autor:
Nancy M. Walker, Daniel R. McHugh, Austin E. Gillen, George Kotzamanis, Craig A. Hodges, Michael J. Mutolo, Lane L. Clarke, Alexander Miron, Jinghua Liu, Lara R. Gawenis, Calvin U. Cotton, Jürgen Bosch, Ashlee M. Strubberg, Dana M. Valerio, Mitchell L. Drumm, Ann Harris
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Small-molecule modulators of cystic fibrosis transmembrane conductance regulator (CFTR) biology show promise in the treatment of cystic fibrosis (CF). A Cftr knockout (Cftr KO) mouse expressing mutants of human CFTR would advance in vivo testing of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074bb98cd20b788ff6ceb44903db6adc
http://link.springer.com/article/10.1038/s41598-019-48105-4
http://link.springer.com/article/10.1038/s41598-019-48105-4
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d742b49748486f125f979d67e04ff8f7
https://doi.org/10.1096/fasebj.2019.33.1_supplement.711.3
https://doi.org/10.1096/fasebj.2019.33.1_supplement.711.3
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b51adee9a4c8d931baf2088c3b9d804f
https://doi.org/10.1096/fasebj.2018.32.1_supplement.747.21
https://doi.org/10.1096/fasebj.2018.32.1_supplement.747.21
Autor:
Casey D. Stefanski, R. John MacLeod, Nancy M. Walker, Jinghua Liu, Lane L. Clarke, Ashlee M. Strubberg, Scott T. Magness
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 253-271 (2018)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Cystic fibrosis (CF) patients and CF mouse models have increased risk for gastrointestinal tumors. CF mice show augmented intestinal proliferation of unknown etiology and an altered intestinal environment. We examined the role of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60f9c5cd68403f7f6692e71d55e2957
https://doi.org/10.1101/156562
https://doi.org/10.1101/156562
Autor:
Lane L. Clarke, R. Zachary Horack, Janet E. Simpson, Jeffrey S. Clark, Nancy M. Walker, Seth L. Alper, Andrew K. Stewart, David H. Vandorpe
Publikováno v:
American Journal of Physiology-Cell Physiology. 300:C276-C286
The recent proposal that Dra/Slc26a3 mediates electrogenic 2Cl−/1HCO3− exchange suggests a required revision of classical concepts of electroneutral Cl− transport across epithelia such as the intestine. We investigated 1) the effect of endogeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd92c6a7f49eb26f255f6b35a5a7460
https://doi.org/10.1152/ajpcell.00366.2010
https://doi.org/10.1152/ajpcell.00366.2010
Autor:
Nancy M. Walker, Erin E. Hoover, Janet E. Simpson, Lane L. Clarke, Clifford W. Schweinfest, Manoocher Soleimani, Jennifer M. Brazill
Publikováno v:
Acta Physiologica. 201:21-31
Aims The apical membrane anion exchanger putative anion transporter-1 (Pat-1) is expressed at significant levels in the lower villus epithelium of murine duodenum. However, previous studies of Cl(−)/HCO₃(−) exchange in the lower villus have fai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30880a804a21db08b2c5fcb0737e64fb
https://doi.org/10.1111/j.1748-1716.2010.02210.x
https://doi.org/10.1111/j.1748-1716.2010.02210.x
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 298:G683-G691
The majority of dietary amino acids are absorbed via the H+-di-/tripeptide transporter Pept1 of the small intestine. Proton influx via Pept1 requires maintenance of intracellular pH (pHi) to sustain the driving force for peptide absorption. The apica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a3b608a8a44597e89471bca8c4ba17
https://doi.org/10.1152/ajpgi.00293.2009
https://doi.org/10.1152/ajpgi.00293.2009
Autor:
Janet E. Simpson, Nancy M. Walker, Gary E. Shull, Lane L. Clarke, Manoocher Soleimani, Clifford W. Schweinfest, Kathryn T. Boyle, Lara R. Gawenis
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 292:G1079-G1088
Basal HCO3− secretion across the duodenum has been shown in several species to principally involve the activity of apical membrane Cl−/HCO3− exchanger(s). To investigate the identity of relevant anion exchanger(s), experiments were performed us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5f21508bd64dcdcb23ac68e3730ce0
https://doi.org/10.1152/ajpgi.00354.2006
https://doi.org/10.1152/ajpgi.00354.2006