Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Nancy L. Weigel"'
Autor:
Paul Basil, Matthew J. Robertson, William E. Bingman, Amit K. Dash, William C. Krause, Ayesha A. Shafi, Badrajee Piyarathna, Cristian Coarfa, Nancy L. Weigel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract The constitutively active androgen receptor (AR) splice variant, AR-V7, plays an important role in resistance to androgen deprivation therapy in castration resistant prostate cancer (CRPC). Studies seeking to determine whether AR-V7 is a par
Externí odkaz:
https://doaj.org/article/b386deb188414a419b94e4253165b97f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Prostate cancer (PCa) is dependent on the androgen receptor (AR). Advanced PCa is treated with an androgen deprivation therapy-based regimen; tumors develop resistance, although they typically remain AR-dependent. Expression of constitutivel
Externí odkaz:
https://doaj.org/article/d596508e4db041fab19ab78aa8fed1fd
Autor:
Anindita Ravindran, Kimiko L. Krieger, Akash K. Kaushik, Hélène Hovington, Sadia Mehdi, Danthasinghe Waduge Badrajee Piyarathna, Vasanta Putluri, Paul Basil, Uttam Rasaily, Franklin Gu, Truong Dang, Jong Min Choi, Rajni Sonavane, Sung Yun Jung, Lisha Wang, Rohit Mehra, Nancy L. Weigel, Nagireddy Putluri, David R. Rowley, Ganesh S. Palapattu, Chantal Guillemette, Louis Lacombe, Éric Lévesque, Arun Sreekumar
Publikováno v:
Cells, Vol 11, Iss 15, p 2329 (2022)
Prostate cancer (PCa) is the second most diagnosed cancer in the United States and is associated with metabolic reprogramming and significant disparities in clinical outcomes among African American (AA) men. While the cause is likely multi-factorial,
Externí odkaz:
https://doaj.org/article/21fa31e76e474fb6b719fbe7d3615cfd
Autor:
Manjul Rana, Jianrong Dong, Matthew J. Robertson, Paul Basil, Cristian Coarfa, Nancy L. Weigel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/a38ab4c701574deab78bca9c62ffb56c
Autor:
Akash K. Kaushik, Ali Shojaie, Katrin Panzitt, Rajni Sonavane, Harene Venghatakrishnan, Mohan Manikkam, Alexander Zaslavsky, Vasanta Putluri, Vihas T. Vasu, Yiqing Zhang, Ayesha S. Khan, Stacy Lloyd, Adam T. Szafran, Subhamoy Dasgupta, David A. Bader, Fabio Stossi, Hangwen Li, Susmita Samanta, Xuhong Cao, Efrosini Tsouko, Shixia Huang, Daniel E. Frigo, Lawrence Chan, Dean P. Edwards, Benny A. Kaipparettu, Nicholas Mitsiades, Nancy L. Weigel, Michael Mancini, Sean E. McGuire, Rohit Mehra, Michael M. Ittmann, Arul M. Chinnaiyan, Nagireddy Putluri, Ganesh S. Palapattu, George Michailidis, Arun Sreekumar
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The molecular alterations driving anti-androgen resistance in prostate cancer are unclear. Here, the authors show, using a network-based approach, that inhibition of the hexosamine biosynthetic pathway is necessary to develop resistance and that incr
Externí odkaz:
https://doaj.org/article/928bd0a4d45444ac89e49f796339b9e4
Autor:
Irina U. Agoulnik, Nancy L. Weigel, Michael M. Ittmann, Christian Coarfa, Kimal Rajapakshe, Rile Li, Anna Frolov, Gregory A. Gandarillas, Egla Suarez, Leif E. Peterson, Manqi Zhang, Alexander I. Agoulnik, Sandra M. Lopez
Sequences of siRNAs and primers and probes for qPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ab3991b523b5cff4a62b6ffd129054
https://doi.org/10.1158/1078-0432.22457363
https://doi.org/10.1158/1078-0432.22457363
Autor:
Leonard M. Neckers, Jane B. Trepel, Jason E. Gestwicki, Nancy L. Weigel, Sanjay V. Malhotra, Vineet Kumar, William E. Bingman, Hao Shao, Abbey D. Zuehlke, Sunmin Lee, Catherine Wells, Kristin E. Beebe, Matthew J. Watson, Nobu Oshima, Genesis M. Rivera-Marquez, Yeong Sang Kim, Michael A. Moses
A Word file that contains Supplementary Methods & Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d15605f2be498002d540bf8cc93d21
https://doi.org/10.1158/0008-5472.22419869
https://doi.org/10.1158/0008-5472.22419869
Autor:
Irina U. Agoulnik, Nancy L. Weigel, Michael M. Ittmann, Christian Coarfa, Kimal Rajapakshe, Rile Li, Anna Frolov, Gregory A. Gandarillas, Egla Suarez, Leif E. Peterson, Manqi Zhang, Alexander I. Agoulnik, Sandra M. Lopez
Correlation analysis between NCOR1 and NCOR2 expression and AR transcriptional output
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6aee87c7e3767bc49aaf7fe13707bc
https://doi.org/10.1158/1078-0432.22457357
https://doi.org/10.1158/1078-0432.22457357
Autor:
Irina U. Agoulnik, Nancy L. Weigel, Michael M. Ittmann, Christian Coarfa, Kimal Rajapakshe, Rile Li, Anna Frolov, Gregory A. Gandarillas, Egla Suarez, Leif E. Peterson, Manqi Zhang, Alexander I. Agoulnik, Sandra M. Lopez
Purpose: Castration therapy in advanced prostate cancer eventually fails and leads to the development of castration-resistant prostate cancer (CRPC), which has no cure. Characteristic features of CRPC can be increased androgen receptor (AR) expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c20de03aabb9a6627410a5ca704ec9
https://doi.org/10.1158/1078-0432.c.6523562
https://doi.org/10.1158/1078-0432.c.6523562
Autor:
Leonard M. Neckers, Jane B. Trepel, Jason E. Gestwicki, Nancy L. Weigel, Sanjay V. Malhotra, Vineet Kumar, William E. Bingman, Hao Shao, Abbey D. Zuehlke, Sunmin Lee, Catherine Wells, Kristin E. Beebe, Matthew J. Watson, Nobu Oshima, Genesis M. Rivera-Marquez, Yeong Sang Kim, Michael A. Moses
Average mouse body weight for Figure 5; PD analyses of C86 +/- JG98 in vivo; in vitro effects of C86 +/- JG98 on other client proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65180a8a7fa088f0a2060163f8db3879
https://doi.org/10.1158/0008-5472.22419872
https://doi.org/10.1158/0008-5472.22419872