Zobrazeno 1 - 10 of 258 pro vyhledávání: '"Nancy L. Weigel"'
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Akademický článek
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Akademický článek
Cistrome and transcriptome analysis identifies unique androgen receptor (AR) and AR-V7 splice variant chromatin binding and transcriptional activities
Autor: Paul Basil, Matthew J. Robertson, William E. Bingman, Amit K. Dash, William C. Krause, Ayesha A. Shafi, Badrajee Piyarathna, Cristian Coarfa, Nancy L. Weigel
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract The constitutively active androgen receptor (AR) splice variant, AR-V7, plays an important role in resistance to androgen deprivation therapy in castration resistant prostate cancer (CRPC). Studies seeking to determine whether AR-V7 is a par
Externí odkaz: https://doaj.org/article/b386deb188414a419b94e4253165b97f
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3
Akademický článek
Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells
Autor: Manjul Rana, Jianrong Dong, Matthew J. Robertson, Cristian Coarfa, Nancy L. Weigel
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Prostate cancer (PCa) is dependent on the androgen receptor (AR). Advanced PCa is treated with an androgen deprivation therapy-based regimen; tumors develop resistance, although they typically remain AR-dependent. Expression of constitutivel
Externí odkaz: https://doaj.org/article/d596508e4db041fab19ab78aa8fed1fd
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4
Akademický článek
Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28) Promotes Tumor Progression and Is Elevated in African American Prostate Cancer Patients
Autor: Anindita Ravindran, Kimiko L. Krieger, Akash K. Kaushik, Hélène Hovington, Sadia Mehdi, Danthasinghe Waduge Badrajee Piyarathna, Vasanta Putluri, Paul Basil, Uttam Rasaily, Franklin Gu, Truong Dang, Jong Min Choi, Rajni Sonavane, Sung Yun Jung, Lisha Wang, Rohit Mehra, Nancy L. Weigel, Nagireddy Putluri, David R. Rowley, Ganesh S. Palapattu, Chantal Guillemette, Louis Lacombe, Éric Lévesque, Arun Sreekumar
Publikováno v: Cells, Vol 11, Iss 15, p 2329 (2022)
Prostate cancer (PCa) is the second most diagnosed cancer in the United States and is associated with metabolic reprogramming and significant disparities in clinical outcomes among African American (AA) men. While the cause is likely multi-factorial,
Externí odkaz: https://doaj.org/article/21fa31e76e474fb6b719fbe7d3615cfd
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8
Data from Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
Autor: Irina U. Agoulnik, Nancy L. Weigel, Michael M. Ittmann, Christian Coarfa, Kimal Rajapakshe, Rile Li, Anna Frolov, Gregory A. Gandarillas, Egla Suarez, Leif E. Peterson, Manqi Zhang, Alexander I. Agoulnik, Sandra M. Lopez
Purpose: Castration therapy in advanced prostate cancer eventually fails and leads to the development of castration-resistant prostate cancer (CRPC), which has no cure. Characteristic features of CRPC can be increased androgen receptor (AR) expressio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c20de03aabb9a6627410a5ca704ec9
https://doi.org/10.1158/1078-0432.c.6523562
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