Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nancy L. Maas"'
Autor:
Stephen P. Santoro, Nancy L. Maas
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 1, Pp 5-6 (2011)
Externí odkaz:
https://doaj.org/article/9123852f1d15491ba16e3f0109fcaeee
Autor:
Constantinos Koumenis, David M. Guttmann, Eric S. Witze, Albert C. Koong, Nancy L. Maas, J. Alan Diehl, Carly M. Sayers, Ioanna Papandreou
Publikováno v:
Molecular Pharmacology. 83:594-604
The Integrated Stress Response (ISR) is a signaling program that enables cellular adaptation to stressful conditions like hypoxia and nutrient deprivation in the tumor microenvironment. An important effector of the ISR is activating transcription fac
Autor:
Ekaterina Bobrovnikova-Marjon, Dariusz Pytel, Jake A. Kushner, Brian Frederick, Hui Zheng, Constantinos Koumenis, J. Alan Diehl, Nancy L. Maas, Nilesh Chitnis, Lewis A. Chodosh, Dhruv K. Pant, Serge Y. Fuchs
Publikováno v:
Molecular Cell. 48:353-364
MicroRNAs typically function at the level of posttranscriptional gene silencing within the cytoplasm; however, increasing evidence suggests that they may also function in nuclear, Argonaut-containing complexes, to directly repress target gene transcr
Autor:
Lisa G. DeFazio-Eli, David P. Toczyski, Jaime Lopez-Mosqueda, Nancy L. Maas, James A. Wohlschlegel, Zophonías O. Jónsson
Publikováno v:
Nature, vol 467, iss 7314
Nature
Nature
Origins of replication are activated throughout the S phase of the cell cycle such that some origins fire early and others fire late to ensure that each chromosome is completely replicated in a timely fashion. However, in response to DNA damage or re
Autor:
Katherine S. Yang-Iott, Craig H. Bassing, Beth A. Helmink, Andrea L. Bredemeyer, Andrea C. Carpenter, Bu Yin, Velibor Savic, Barry P. Sleckman, Nancy L. Maas
Publikováno v:
Molecular Cell. 34:298-310
A hallmark of the cellular response to DNA double-strand breaks (DSBs) is histone H2AX phosphorylation in chromatin to generate gamma-H2AX. Here, we demonstrate that gamma-H2AX densities increase transiently along DNA strands as they are broken and r
Publikováno v:
Molecular Cell. 23(1):109-119
Histone modifications, including H3 K56 acetylation, have been implicated in DNA damage tolerance. Here, we present evidence that Hst3 and Hst4, two paralogues of the histone deacetylase Sir2, target the cell cycle-regulated acetylation of H3 on K56
Autor:
J. Alan Diehl, Nancy L. Maas
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 21(4)
The endoplasmic reticulum (ER) is a highly specialized organelle that provides an oxidizing, profolding environment for protein synthesis and maturation. The ER also hosts a dynamic signaling network that can sense and respond to physiologic changes
Publikováno v:
Cancer biologytherapy. 15(8)
Restriction of nutrients and oxygen in the tumor microenvironment disrupts ER homeostasis and adaptation to such stress is mediated by the key UPR effector PERK. Given its pro-tumorigenic activity, significant efforts have been made to elucidate the
Autor:
Benjamin J. Fuerth, Russell G. Jones, David Bungard, Craig B. Thompson, Ping-Yao Zeng, Benoit Viollet, David Carling, Nancy L. Maas, Shelley L. Berger, Brandon Faubert
Regulation of Energy Homeostasis The mammalian AMP-activated protein kinase (AMPK) is a serine/threonine kinase complex that regulates cellular energy homeostasis. However, the mechanisms by which AMPK mediates transcriptional responses to metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd477571e88e2378a9dfccca588e686
https://europepmc.org/articles/PMC3922052/
https://europepmc.org/articles/PMC3922052/
Autor:
Hong Xu, Judith Recht, Assen Roguev, David P. Toczyski, Phil Hieter, Shelley L. Berger, Kyle M. Miller, Huiming Ding, Jack Greenblatt, Sean R. Collins, C. James Ingles, C. David Allis, Kristin Ingvarsdottir, Nancy L. Maas, Jonathan S. Weissman, Grant W. Brown, Benjamin Cheng, Clement Chu, Brenda J. Andrews, Maya Schuldiner, Marinella Gebbia, Michael Shales, Zhiguo Zhang, Jeffrey Fillingham, Charles Boone, Nevan J. Krogan, Junhong Han, Andrew Emili
Publikováno v:
Nature. 446(7137)
Defining the functional relationships between proteins is critical for understanding virtually all aspects of cell biology. Large-scale identification of protein complexes has provided one important step towards this goal; however, even knowledge of