Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nancy L. Buechler"'
Autor:
Nadeem Wajih, Swati Basu, Anuj Jailwala, Hee Won Kim, David Ostrowski, Andreas Perlegas, Crystal A. Bolden, Nancy L. Buechler, Mark T. Gladwin, David L. Caudell, Elaheh Rahbar, Martha A. Alexander-Miller, Vidula Vachharajani, Daniel B. Kim-Shapiro
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 1026-1039 (2017)
Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions, increasing rigidity, fragility, calcium influx-mediated dehydration, and adhesivity of red blood cells. Increased red cell fragility results in he
Externí odkaz:
https://doaj.org/article/6cbd35867bd04e4cafdee1f7691998b9
Autor:
Xianfeng Wang, Nancy L. Buechler, Alan G. Woodruff, David L. Long, Manal Zabalawi, Barbara K. Yoza, Charles E. McCall, Vidula Vachharajani
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2738 (2018)
Sepsis and septic shock are the leading causes of death in non-coronary intensive care units worldwide. During sepsis-associated immune dysfunction, the early/hyper-inflammatory phase transitions to a late/hypo-inflammatory phase as sepsis progresses
Externí odkaz:
https://doaj.org/article/b96f38a9386c43b0b5f9eab1754900fc
Autor:
Xuewei Zhu, Cristina M. Furdui, Matthew A. Quinn, Peter W. Stacpoole, Ellen E. Quillen, Nancy L. Buechler, John S. Parks, Charles E. McCall, Jennifer Martinez, Manal Zabalawi, David L. Long, Rabina Mainali, Chia-Chi C. Key
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Dramatic metabolic reprogramming between an anabolic resistance and catabolic tol-erance state occurs within the immune system in response to systemic infection with the sepsis syndrome. While metabolic tissues such as the liver are subject to end-or
Autor:
Rabina Mainali, John S. Parks, Jennifer Martinez, Manal Zabalawi, Peter W. Stacpoole, Cristina M. Furdui, Chia-Chi C. Key, Ellen E. Quillen, Charles E. McCall, Nancy L. Buechler, Xuewei Zhu, David L. Long, Matthew A. Quinn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e2ef38b4119bdb506d453ffaf23b883
https://doi.org/10.7554/elife.64611.sa2
https://doi.org/10.7554/elife.64611.sa2
Autor:
David L. Caudell, Nancy L. Buechler, Anuj Jailwala, Mark T. Gladwin, Vidula Vachharajani, Hee Won Kim, Daniel B. Kim-Shapiro, Andreas Perlegas, Martha A. Alexander-Miller, Elaheh Rahbar, Nadeem Wajih, Swati Basu, Crystal Bolden, David Ostrowski
Publikováno v:
Redox Biology, Vol 12, Iss, Pp 1026-1039 (2017)
Redox Biology
Redox Biology
Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions, increasing rigidity, fragility, calcium influx-mediated dehydration, and adhesivity of red blood cells. Increased red cell fragility results in he
Publikováno v:
Journal of Inflammation Research
XianFeng Wang,Nancy L Buechler,Barbara K Yoza, Charles E McCall,Vidula Vachharajani Department of Anesthesiology, Medicine and Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA Background: Morbid obesity increases the cost of care in cr
Autor:
Barbara K. Yoza, Cristina M. Furdui, Vidula Vachharajani, David L. Long, Nancy L. Buechler, Charles E. McCall, Xianfeng Wang
RATIONALE: Obesity increases morbidity and mortality in acute illnesses such as sepsis and septic shock. We showed previously that the early/hyper-inflammatory phase of sepsis is exaggerated in obese mice with sepsis; sirtuin 2 (SIRT2) modulates seps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340d333d9f3ebf0ab1d5c6051d83a1a1
https://europepmc.org/articles/PMC6380915/
https://europepmc.org/articles/PMC6380915/
Autor:
Charles E. McCall, Vidula Vachharajani, Manal Zabalawi, Mihai G. Netea, Nancy L. Buechler, Tie Fu Liu, Barbara K. Yoza, Peter W. Stacpoole, Rob J.W. Arts, David L. Long, Ayana Martin
Publikováno v:
Jci Insight, 3,
Jci Insight, 3, 15, pp.
Jci Insight, 3, 15, pp.
Limited understanding of the mechanisms responsible for life-threatening organ and immune failure hampers scientists' ability to design sepsis treatments. Pyruvate dehydrogenase kinase 1 (PDK1) is persistently expressed in immune-tolerant monocytes o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11e20eff174b8a19c4280c8eda21df8
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/194752
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/194752
Publikováno v:
Obesity. 23:1209-1217
Objective Obesity, a Sirtuin-1 (SIRT-1) deficient state, increases morbidity and resource utilization in critically ill patients. SIRT-1 deficiency increases microvascular inflammation and mortality in early sepsis. Our objective was to study the eff
Publikováno v:
Journal of Immunology Research
Journal of Immunology Research, Vol 2017 (2017)
Journal of Immunology Research, Vol 2017 (2017)
Objective. Sepsis and septic shock, the leading causes of death in noncoronary intensive care units, kill more than 200,000/year in the US alone. Circulating cell-endothelial cell interactions are the rate determining factor in sepsis inflammation. S